Role of the Wada test and functional magnetic resonance imaging in preoperative mapping of language and memory: two atypical cases

The Wada test is an invasive procedure used to determine cerebral memory and language dominance as well as risk of cognitive deficits following neurosurgery. However, the potential risks of Wada testing have led some to consider foregoing Wada testing in candidates for resective epilepsy surgery with right hemispheric seizure onset. We present two atypical cases in which the Wada test showed unexpected memory and language lateralization. These cases underscore the importance of functional magnetic resonance in which imaging and Wada examination in right-handed individuals even when the lesion would not suggest atypical language representation.

[1]  J. A. Frost,et al.  Determination of language dominance using functional MRI: A comparison with the Wada test , 2011, Neurology.

[2]  Jeffrey R Binder,et al.  Language lateralization by fMRI and Wada testing in 229 patients with epilepsy: Rates and predictors of discordance , 2013, Epilepsia.

[3]  T. Quirico-Santos,et al.  Resection of the epileptogenic lesion abolishes seizures and reduces inflammatory cytokines of patients with temporal lobe epilepsy , 2013, Journal of Neuroimmunology.

[4]  Philippe Kahane,et al.  Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results , 2008, Neuropsychiatric disease and treatment.

[5]  E. Ritzl,et al.  Characterization of atypical language activation patterns in focal epilepsy , 2014, Annals of neurology.

[6]  Johannes B Reitsma,et al.  Can fMRI safely replace the Wada test for preoperative assessment of language lateralisation? A meta-analysis and systematic review , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[7]  E. T. Possing,et al.  Functional MRI and Wada studies in patients with interhemispheric dissociation of language functions , 2008, Epilepsy & Behavior.

[8]  Nathalie Jette,et al.  Complications of epilepsy surgery—A systematic review of focal surgical resections and invasive EEG monitoring , 2013, Epilepsia.

[9]  Russell A. Epstein,et al.  The Parahippocampal Place Area Recognition, Navigation, or Encoding? , 1999, Neuron.

[10]  W. Barr,et al.  The intracarotid amobarbital procedure: When is it worth repeating? , 2012, Epilepsia.

[11]  Eftychia Z. Kapsalaki,et al.  Preoperative Evaluation with fMRI of Patients with Intracranial Gliomas , 2012, Radiology research and practice.

[12]  J. A. Frost,et al.  Language dominance in neurologically normal and epilepsy subjects , 1999 .

[13]  Jeffrey R. Binder,et al.  Functional MRI is a valid noninvasive alternative to Wada testing , 2011, Epilepsy & Behavior.

[14]  G. Ojemann,et al.  Cortical stimulation mapping and Wada results demonstrate a normal variant of right hemisphere language organization , 2012, Epilepsia.

[15]  Sallie Baxendale,et al.  The role of the Wada test in the surgical treatment of temporal lobe epilepsy: An international survey , 2008, Epilepsia.

[16]  Kenneth Pugh,et al.  Language lateralization in epilepsy patients: fMRI validated with the Wada procedure , 2009, Epilepsia.

[17]  Ashwini Sharan,et al.  Intracarotid amobarbital procedure for epilepsy surgery , 2011, Epilepsy & Behavior.

[18]  Susan Bookheimer,et al.  Pre-Surgical Language Mapping with Functional Magnetic Resonance Imaging , 2007, Neuropsychology Review.

[19]  C. Elger,et al.  Cerebral lesions can impair fMRI‐based language lateralization , 2009, Epilepsia.

[20]  H. Noordmans,et al.  Development of a functional magnetic resonance imaging protocol for intraoperative localization of critical temporoparietal language areas , 2002, Annals of neurology.

[21]  Bong Soo Kim,et al.  Body MR imaging: fast, efficient, and comprehensive. , 2014, Radiologic clinics of North America.

[22]  S. Mirsattari,et al.  Functional Magnetic Resonance Imaging for Language Mapping in Temporal Lobe Epilepsy , 2012, Epilepsy research and treatment.

[23]  Christine Delmaire,et al.  Productive and perceptive language reorganization in temporal lobe epilepsy , 2005, NeuroImage.

[24]  K. Radhakrishnan,et al.  Extent of initial injury determines language lateralization in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) , 2009, Epilepsia.

[25]  Tobias Loddenkemper,et al.  Complications during the Wada test , 2008, Epilepsy & Behavior.

[26]  E. Ritzl,et al.  The effect of seizure focus on regional language processing areas , 2012, Epilepsia.

[27]  S. Sato,et al.  fMRI language task panel improves determination of language dominance , 2004, Neurology.

[28]  C. E. Elger,et al.  Patterns of Language Dominance in Focal Left and Right Hemisphere Epilepsies: Relation to MRI Findings, EEG, Sex, and Age at Onset of Epilepsy , 1997, Brain and Cognition.

[29]  J. Paolicchi Is the Wada test still relevant? Yes. , 2008, Archives of neurology.

[30]  Mark D. Johnson,et al.  The Role of the Human Thalamus in Language and Memory: Evidence from Electrophysiological Studies , 2000, Brain and Cognition.

[31]  F. Woermann,et al.  Epileptic activity influences the speech organization in medial temporal lobe epilepsy. , 2003, Brain : a journal of neurology.

[32]  M. Duchowny,et al.  Atypical Propositional Language Organization in Prenatal and Early-Acquired Temporal Lobe Lesions , 2010, Journal of child neurology.

[33]  G. Morris,et al.  Unexpected right hemisphere language representation identified by the intracarotid amobarbital procedure in right-handed epilepsy surgery candidates , 2008, Epilepsy & Behavior.

[34]  M. Erb,et al.  BOLD Signal in memory paradigms in hippocampal region depends on echo time , 2013, Journal of magnetic resonance imaging : JMRI.

[35]  W H Theodore,et al.  Seizure focus affects regional language networks assessed by fMRI , 2005, Neurology.

[36]  G. Flint,et al.  Seizures and epilepsy. , 1988, British journal of neurosurgery.

[37]  J. Binder,et al.  Naming outcome prediction in patients with discordant Wada and fMRI language lateralization , 2013, Epilepsy & Behavior.

[38]  Gus Baker,et al.  The base rate of Wada test failure , 2008, Epilepsy & Behavior.

[39]  K. Dijkstra,et al.  Patterns and predictors of atypical language representation in epilepsy , 2012, Journal of Neurology, Neurosurgery & Psychiatry.

[40]  Andrew J. Cole,et al.  Surgical Treatment of the Epilepsies, 2nd Ed. , 1994, Neurology.

[41]  S. Engel,et al.  Dynamics of the Hippocampus During Encoding and Retrieval of Face-Name Pairs , 2003, Science.

[42]  M. Hamberger,et al.  Language Organization and Reorganization in Epilepsy , 2011, Neuropsychology Review.

[43]  Jeffrey R Binder,et al.  A Comparison of Two fMRI Protocols for Eliciting Hippocampal Activation , 2005, Epilepsia.

[44]  George Tomlinson,et al.  Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature. , 2003, Radiology.

[45]  M Ingvar,et al.  Functional MRI with reduced susceptibility artifact: high-resolution mapping of episodic memory encoding , 2001, Neuroreport.