Brain function in spider phobia

Measurements of regional cerebral blood flow (rCBF) were performed in 16 women suffering from spider phobia. The non-invasive 133Xe inhalation method, giving information about the blood flow of superficial areas, was used. The subjects were studied under three conditions: during resting, when exposed to a videotape showing nature scenery, and finally when watching a video with living spiders. During the rCBF measurements the subjects' behaviour was registered systematically and respiration, blood pressure, Pco2, and heart rate were monitored. Eight subjects who showed and reported severe panic during the spider exposure had marked rCBF decreases in frontal areas, especially in the right hemisphere. The remaining eight subjects displayed a more efficient control of their emotions and became frightened, but not panic-stricken, during the spider exposure. These showed a consistent rCBF increase in the right frontal area compared to neutral stimulation. Thus, results revealed significant functional changes in the frontal cortex in subjects with spider phobia during phobogenic exposure. It seems likely that these frontal changes are related to the experience and control of phobic anxiety.

[1]  D E Kuhl,et al.  Positron emission tomographic evaluation of cerebral blood flow during state anxiety in simple phobia. , 1989, Archives of general psychiatry.

[2]  A. Johanson,et al.  Psychometric characteristics in patients with frontal lobe degeneration of non-Alzheimer type. , 1989, Archives of gerontology and geriatrics.

[3]  D. Stuss,et al.  "No longer Gage": frontal lobe dysfunction and emotional changes. , 1992, Journal of consulting and clinical psychology.

[4]  Jordan Grafman,et al.  Handbook of Neuropsychology , 1991 .

[5]  P E Roland,et al.  Cortical organization of voluntary behavior in man. , 1985, Human neurobiology.

[6]  J. Risberg,et al.  Behavioral observations during performance of the WAIS Block Design Test related to abnormalities of regional cerebral blood flow in organic dementia. , 1986, Journal of clinical and experimental neuropsychology.

[7]  The Primate Brain: Advances in Primatology, vol 1. , 1971 .

[8]  C. MacLeod,et al.  Discrimination of threat cues without awareness in anxiety states. , 1986, Journal of abnormal psychology.

[9]  J. Risberg,et al.  Regional Cerebral Blood Flow in Sign Language Users , 1993, Brain and Language.

[10]  Joseph E. LeDoux,et al.  Emotion, memory and the brain. , 1994, Scientific American.

[11]  W D Obrist,et al.  Effects of task difficulty on regional cerebral blood flow: relationships with anxiety and performance. , 1988, Psychophysiology.

[12]  K. Pribram,et al.  Social and Emotional Self‐Regulation a , 1995, Annals of the New York Academy of Sciences.

[13]  E. O. Hovey.  The New York Academy of Sciences , 1963, Nature.

[14]  Don M. Tucker,et al.  Left orbital frontal activation in pathological anxiety , 1992 .

[15]  Peter Herscovitch,et al.  A focal brain abnormality in panic disorder, a severe form of anxiety , 1984, Nature.

[16]  T Greitz,et al.  Regional cerebral blood flow during experimental phobic fear. , 2007, Psychophysiology.

[17]  R. Michels,et al.  Diagnostic and Statistical Manual of Mental Disorders, 3rd ed , 1981 .

[18]  T. Insel,et al.  Anxiety and cerebral blood flow during behavioral challenge. Dissociation of central from peripheral and subjective measures. , 1989, Archives of general psychiatry.

[19]  J. Risberg,et al.  Adaptation in Different Types of Dementia and in Normal Elderly Subjects , 1990 .

[20]  D. Stuss,et al.  Frontal lobe influences on delusions: a clinical perspective. , 1990, Schizophrenia bulletin.

[21]  Bernice B. Capusten.  Impact of Functional Imaging in Neurology and Psychiatry , 1989 .

[22]  W. Obrist,et al.  Regional cerebral blood flow estimated by 133-xenon inhalation. , 1975, Stroke.

[23]  Nathaniel M. Alpert,et al.  The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation , 1997, Biological Psychiatry.

[24]  L. Gustafson,et al.  Clinical picture of frontal lobe degeneration of non-Alzheimer type. , 1993, Dementia.

[25]  N. Alpert,et al.  A positron emission tomographic study of simple phobic symptom provocation. , 1995, Archives of general psychiatry.

[26]  J. Risberg.  Regional cerebral blood flow measurements by 133Xe-inhalation: Methodology and applications in neuropsychology and psychiatry , 1980, Brain and Language.

[27]  S. Arndt,et al.  Depression and anxiety following traumatic brain injury. , 1993, The Journal of neuropsychiatry and clinical neurosciences.

[28]  Joseph E. LeDoux.  Emotion, Memory and the Brain The neural routes underlying the formation of memories about primitive emotional experiences, such as fear, have been traced , 1994 .

[29]  Stephen Meredith Williams.  Factor Analysis of the Edinburgh Handedness Inventory , 1986, Cortex.

[30]  S. Stone-Elander,et al.  Functional neuroanatomy of visually elicited simple phobic fear: additional data and theoretical analysis. , 1995, Psychophysiology.

[31]  K H PRIBRAM,et al.  A further experimental analysis of the behavioral deficit that follows injury to the primate frontal cortex. , 1961, Experimental neurology.

[32]  Keith J. Holyoak,et al.  Structure and Functions of the Human Prefrontal Cortex , 1996 .

[33]  C. Spielberger,et al.  Manual for the State-Trait Anxiety Inventory , 1970 .

[34]  C. W. Hughes.  Emotion: Theory, Research and Experience , 1982 .

[35]  A. Luria.  Higher Cortical Functions in Man , 1980, Springer US.

[36]  Mortimer Mishkin,et al.  Chapter 12 – THE AMYGDALA: SENSORY GATEWAY TO THE EMOTIONS , 1986 .

[37]  Karl J. Friston,et al.  Comparing Functional (PET) Images: The Assessment of Significant Change , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  D. Tucker,et al.  Motivated attention: Anxiety and the frontal executive functions. , 1992 .

[39]  J. Risberg,et al.  Regional Cerebral Blood Flow by 133Xenon Inhalation: Preliminary Evaluation of an Initial Slope Index in Patients with Unstable Flow Compartments , 1975, Stroke.

[40]  G. Deutsch,et al.  Cerebral blood flow evidence of right frontal activation in attention demanding tasks. , 1987, The International journal of neuroscience.

[41]  Richard J. Davidson,et al.  Affect, cognition, and hemispheric specialization. , 1985 .

[42]  D. Ingvar.  "Memory of the future": an essay on the temporal organization of conscious awareness. , 1985, Human neurobiology.