Identification and characterization of a potent and selective inhibitor of human urate transporter 1
暂无分享,去创建一个
Jiasheng Chen | Haixin Li | Yuan-xin Tian | Ting Wu | Ying Cao | W. Fu | Jianxin Pang | Baomin Xi | Pingzheng Zhou | Shuai Dong
[1] N. Malara,et al. The treatment of hyperuricemia. , 2016, International journal of cardiology.
[2] Xilin Yang,et al. Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study , 2016, Journal of Translational Medicine.
[3] N. Schlesinger,et al. New and Pipeline Drugs for Gout , 2016, Current Rheumatology Reports.
[4] N. Horiba,et al. Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone , 2016, The Journal of Pharmacology and Experimental Therapeutics.
[5] Sheridan M. Hoy. Lesinurad: First Global Approval , 2016, Drugs.
[6] H. Xie,et al. Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy , 2016, Molecular medicine reports.
[7] Jiong Lan,et al. Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model. , 2016, Bioorganic & medicinal chemistry letters.
[8] M. Cravets,et al. Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol , 2016, Annals of the rheumatic diseases.
[9] C. Mende. Management of Chronic Kidney Disease: The Relationship Between Serum Uric Acid and Development of Nephropathy , 2015, Advances in Therapy.
[10] R. Blantz,et al. Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters. , 2015, Clinical journal of the American Society of Nephrology : CJASN.
[11] Xu Liu,et al. Mangiferin Inhibits Renal Urate Reabsorption by Modulating Urate Transporters in Experimental Hyperuricemia. , 2015, Biological & pharmaceutical bulletin.
[12] S. Kardia,et al. Uric Acid: A Missing Link Between Hypertensive Pregnancy Disorders and Future Cardiovascular Disease? , 2015, Mayo Clinic proceedings.
[13] J. Singh,et al. Investigational drugs for hyperuricemia , 2015, Expert opinion on investigational drugs.
[14] C. Storgard,et al. Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males , 2015, Drug design, development and therapy.
[15] C. Díaz-Torné,et al. New medications in development for the treatment of hyperuricemia of gout , 2015, Current opinion in rheumatology.
[16] J. Fitzgerald,et al. Evolution of management of gout: a comparison of recent guidelines , 2015, Current opinion in rheumatology.
[17] J. Ruan,et al. Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice. , 2014, Journal of ethnopharmacology.
[18] C. Peralta,et al. Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2002. , 2014, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[19] Shu-Qing Wang,et al. Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice. , 2014, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[20] S. Zeng,et al. Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug-drug interaction in rats. , 2014, Journal of ethnopharmacology.
[21] M. Bach,et al. Uricosuric drugs: the once and future therapy for hyperuricemia? , 2014, Current opinion in rheumatology.
[22] L. Abenhaim,et al. Impact of allopurinol on risk of myocardial infarction , 2014, Annals of the rheumatic diseases.
[23] W. Welsh,et al. Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterization. , 2012, Molecular pharmaceutics.
[24] G. Burckhardt. Drug transport by Organic Anion Transporters (OATs). , 2012, Pharmacology & therapeutics.
[25] Qing-Yu Zhang,et al. Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats , 2012, Evidence-based complementary and alternative medicine : eCAM.
[26] P. Sexton,et al. Drug transporters in drug efficacy and toxicity. , 2012, Annual review of pharmacology and toxicology.
[27] C. H. Cheng,et al. Morin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney Cells , 2007, Drug Metabolism and Disposition.
[28] Hirotaka Matsuo,et al. Molecular identification of a renal urate–anion exchanger that regulates blood urate levels , 2002, Nature.
[29] H. Endou,et al. Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. , 2001, European journal of pharmacology.
[30] Yuichi Sugiyama,et al. Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs. , 2005, Annual review of pharmacology and toxicology.