Adult mouse and human airway epithelial basal stem cells

[1]  Jessie Huang,et al.  Induced pluripotent stem cells for generating lung alveolar epithelial cells and modelling respiratory disease , 2021, Lung Stem Cells in Development, Health and Disease.

[2]  F. Hawkins,et al.  Induced pluripotent stem cells for generating lung airway stem cells and modelling respiratory disease , 2021 .

[3]  Aleksandra Tata,et al.  Stem cells of submucosal glands: their function as tissue stem cells and a reserve population for airway repair , 2021 .

[4]  Paul J. Hoover,et al.  Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients , 2020, bioRxiv.

[5]  D. Pe’er,et al.  A Single-cell Atlas of the Human Healthy Airways. , 2020, American journal of respiratory and critical care medicine.

[6]  C. Yao,et al.  Single Cell Reconstruction of Human Basal Cell Diversity in Normal and IPF Lung. , 2020, American journal of respiratory and critical care medicine.

[7]  J. Sucre,et al.  Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging. , 2020, Cell stem cell.

[8]  C. von Kalle,et al.  COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis , 2020, Nature Biotechnology.

[9]  S. Randell,et al.  Assessing Human Airway Epithelial Progenitor Cells for Cystic Fibrosis Cell Therapy. , 2020, American journal of respiratory cell and molecular biology.

[10]  J. Fowler,et al.  Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium , 2020, Nature Genetics.

[11]  J. C. Love,et al.  Rho/SMAD/mTOR triple inhibition enables long-term expansion of human neonatal tracheal aspirate-derived airway basal cell-like cells , 2020, Pediatric Research.

[12]  Matthew J. Vincent,et al.  Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis , 2020, Cell.

[13]  Taylor M. Matte,et al.  Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells , 2020, bioRxiv.

[14]  Alyssa J. Miller,et al.  In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution. , 2020, Developmental cell.

[15]  J. Tost,et al.  Recent findings in the genetics and epigenetics of asthma and allergy , 2020, Seminars in Immunopathology.

[16]  M. Stratton,et al.  Tobacco exposure and somatic mutations in normal human bronchial epithelium , 2019, Nature.

[17]  C. Ruppert,et al.  WNT/RYK signaling restricts goblet cell differentiation during lung development and repair , 2019, Proceedings of the National Academy of Sciences.

[18]  W. Cardoso,et al.  Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation , 2019, eLife.

[19]  Hongmei Mou,et al.  SMAD Signaling Restricts Mucous Cell Differentiation In Human Airway Epithelium. , 2019, American journal of respiratory cell and molecular biology.

[20]  Irving L. Weissman,et al.  A molecular cell atlas of the human lung from single cell RNA sequencing , 2019, Nature.

[21]  P. Walentek,et al.  ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia , 2019, bioRxiv.

[22]  Fabian J Theis,et al.  A cellular census of human lungs identifies novel cell states in health and in asthma , 2019, Nature Medicine.

[23]  A. Choi,et al.  Integrins &agr;v&bgr;5 and &agr;v&bgr;6 Mediate IL‐4‐induced Collective Migration in Human Airway Epithelial Cells , 2019, American journal of respiratory cell and molecular biology.

[24]  E. Cormet-Boyaka,et al.  Optimization of Normal Human Bronchial Epithelial (NHBE) Cell 3D Cultures for in vitro Lung Model Studies , 2019, Scientific Reports.

[25]  A. Oudenaarden,et al.  Long‐term expanding human airway organoids for disease modeling , 2019, The EMBO journal.

[26]  C. Marquette,et al.  Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures , 2019, Development.

[27]  S. Reynolds,et al.  Regulation of Human Airway Epithelial Tissue Stem Cell Differentiation by β‐Catenin, P300, and CBP , 2018, Stem cells.

[28]  Aviv Regev,et al.  A revised airway epithelial hierarchy includes CFTR-expressing ionocytes , 2018, Nature.

[29]  J. Shay,et al.  Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function. , 2018, American journal of physiology. Lung cellular and molecular physiology.

[30]  Alex K. Shalek,et al.  Allergic inflammatory memory in human respiratory epithelial progenitor cells , 2018, Nature.

[31]  Allon M. Klein,et al.  A single cell atlas of the tracheal epithelium reveals the CFTR-rich pulmonary ionocyte , 2018, Nature.

[32]  Daniel T. Montoro,et al.  Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. , 2018, Cell stem cell.

[33]  Ryan D. Chow,et al.  Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. , 2018, Cell stem cell.

[34]  M. Salathe,et al.  Modulation of Wnt signaling is essential for the differentiation of ciliated epithelial cells in human airways , 2017, FEBS letters.

[35]  E. Morrisey,et al.  Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. , 2017, Cell stem cell.

[36]  Yutaka Suzuki,et al.  Long-term expansion of alveolar stem cells derived from human iPS cells in organoids , 2017, Nature Methods.

[37]  M. Birchall,et al.  Optimized isolation and expansion of human airway epithelial basal cells from endobronchial biopsy samples , 2017, Journal of tissue engineering and regenerative medicine.

[38]  D. Kotton,et al.  Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. , 2017, Cell stem cell.

[39]  Ahmad S. Khalil,et al.  Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cells , 2017, The Journal of clinical investigation.

[40]  E. Rawlins,et al.  FGFR2 is required for airway basal cell self-renewal and terminal differentiation , 2017, Development.

[41]  S. Randell,et al.  Pharmacological Rescue of Conditionally Reprogrammed Cystic Fibrosis Bronchial Epithelial Cells , 2017, American journal of respiratory cell and molecular biology.

[42]  Laura M. Palermo,et al.  A three-dimensional model of human lung development and disease from pluripotent stem cells , 2017, Nature Cell Biology.

[43]  G. Smyth,et al.  Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway , 2017, PLoS biology.

[44]  M. Goodheart,et al.  Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands , 2016, Stem cells.

[45]  S. Janes,et al.  Expansion of Human Airway Basal Stem Cells and Their Differentiation as 3D Tracheospheres. , 2016, Methods in molecular biology.

[46]  Hongmei Mou,et al.  Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. , 2016, Cell stem cell.

[47]  P. de Coppi,et al.  Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering. , 2016, American journal of respiratory and critical care medicine.

[48]  M. Rao,et al.  Detailed Characterization of Human Induced Pluripotent Stem Cells Manufactured for Therapeutic Applications , 2016, Stem Cell Reviews and Reports.

[49]  M. A. Basson,et al.  An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium , 2016, Developmental cell.

[50]  B. Hogan,et al.  BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors , 2016, Development.

[51]  S. Muro,et al.  Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells , 2015, Stem cell reports.

[52]  X. Varelas,et al.  Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. , 2015, Developmental cell.

[53]  Berthold Göttgens,et al.  Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium , 2015, Cell reports.

[54]  Borja Saez,et al.  Parent stem cells can serve as niches for their own daughter cells , 2015, Nature.

[55]  Pieter S. Hiemstra,et al.  Basal Cells Contribute to Innate Immunity of the Airway Epithelium through Production of the Antimicrobial Protein RNase 7 , 2015, The Journal of Immunology.

[56]  Gail H Deutsch,et al.  In vitro generation of human pluripotent stem cell derived lung organoids , 2015, eLife.

[57]  Rui Zhao,et al.  Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. , 2015, Cell stem cell.

[58]  Hong Zhang,et al.  Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors , 2015, Development.

[59]  Amy Y. Chen,et al.  Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. , 2015, Cell reports.

[60]  Xinyu Wang,et al.  The role of airway epithelial cells and innate immune cells in chronic respiratory disease , 2014, Nature Reviews Immunology.

[61]  L. Liao,et al.  The Prostate Basal Cell (BC) Heterogeneity and the p63-Positive BC Differentiation Spectrum in Mice , 2014, International journal of biological sciences.

[62]  A. Staruschenko,et al.  Role of Rho GDP Dissociation Inhibitor α in Control of Epithelial Sodium Channel (ENaC)-mediated Sodium Reabsorption* , 2014, The Journal of Biological Chemistry.

[63]  S. Ogawa,et al.  Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells , 2014, Stem cell reports.

[64]  Timothy R. Fallon,et al.  Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. , 2014, Developmental cell.

[65]  X. Varelas,et al.  The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. , 2014, Developmental cell.

[66]  F. Gage,et al.  Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells , 2014, Proceedings of the National Academy of Sciences.

[67]  G. Vunjak‐Novakovic,et al.  Highly efficient generation of airway and lung epithelial cells from human pluripotent stem cells , 2013, Nature Biotechnology.

[68]  S. Reynolds,et al.  Regulation of Trachebronchial Tissue‐Specific Stem Cell Pool Size , 2013, Stem cells.

[69]  S. Groshong,et al.  Human tracheobronchial basal cells. Normal versus remodeling/repairing phenotypes in vivo and in vitro. , 2013, American journal of respiratory cell and molecular biology.

[70]  Benjamin D. Medoff,et al.  Dedifferentiation of committed epithelial cells into stem cells in vivo , 2013, Nature.

[71]  R. Poulsom,et al.  Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors , 2013, eLife.

[72]  Yan Geng,et al.  p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia , 2013, Proceedings of the National Academy of Sciences.

[73]  Vladimir Vinarsky,et al.  Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge. , 2013, American journal of respiratory cell and molecular biology.

[74]  R. Rancourt,et al.  Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2. , 2013, American journal of respiratory cell and molecular biology.

[75]  Ivana V. Yang,et al.  Epigenetic mechanisms and the development of asthma. , 2012, The Journal of allergy and clinical immunology.

[76]  J. Rossant,et al.  Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein , 2012, Nature Biotechnology.

[77]  Chad A. Cowan,et al.  Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. , 2012, Cell stem cell.

[78]  H. Snoeck,et al.  Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. , 2012, Cell stem cell.

[79]  S. Sinha,et al.  ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation , 2012, Development.

[80]  P. Reynolds,et al.  Stem Cells , Tissue Engineering , and Hematopoietic Elements-Catenin Dosage Is a Critical Determinant of Tracheal Basal Cell Fate Determination , 2011 .

[81]  B. Hogan,et al.  Notch-dependent differentiation of adult airway basal stem cells. , 2011, Cell stem cell.

[82]  R. Crystal,et al.  The Human Airway Epithelial Basal Cell Transcriptome , 2011, PloS one.

[83]  H. Hammad,et al.  Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses , 2011, Allergy.

[84]  C. Schaniel,et al.  Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells , 2011, Nature Biotechnology.

[85]  J. Tost,et al.  Epigenetic mechanisms and the relationship to childhood asthma , 2010, European Respiratory Journal.

[86]  Scott H Randell,et al.  Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling , 2010, Disease Models & Mechanisms.

[87]  Christopher P Crum,et al.  p63 in epithelial survival, germ cell surveillance, and neoplasia. , 2010, Annual review of pathology.

[88]  Scott H. Randell,et al.  Basal cells as stem cells of the mouse trachea and human airway epithelium , 2009, Proceedings of the National Academy of Sciences.

[89]  D. Melton,et al.  Notch signaling promotes airway mucous metaplasia and inhibits alveolar development , 2009, Development.

[90]  B. Hogan,et al.  Ciliated epithelial cell lifespan in the mouse trachea and lung. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[91]  T. Mariani,et al.  Conditional Stabilization of β‐Catenin Expands the Pool of Lung Stem Cells , 2008, Stem cells.

[92]  R. Hajj,et al.  Basal Cells of the Human Adult Airway Surface Epithelium Retain Transit‐Amplifying Cell Properties , 2007, Stem cells.

[93]  Hoang Nguyen,et al.  Tcf3 Governs Stem Cell Features and Represses Cell Fate Determination in Skin , 2006, Cell.

[94]  B. Péault,et al.  Aquaporin‐3 Expression in Human Fetal Airway Epithelial Progenitor Cells , 2005, Stem cells.

[95]  N. Zheleznova,et al.  Rho Small GTPases Activate the Epithelial Na+ Channel* , 2004, Journal of Biological Chemistry.

[96]  Simon C Watkins,et al.  In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[97]  S. Randell,et al.  A subset of mouse tracheal epithelial basal cells generates large colonies in vitro. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[98]  Simon C Watkins,et al.  Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. , 2004, The American journal of pathology.

[99]  D. Jablons,et al.  Integrin (cid:1) v (cid:2) 8-Mediated Activation of Transforming Growth Factor- (cid:2) Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue , 2022 .

[100]  M. Aldrich,et al.  Pathogenesis of mucous cell metaplasia in a murine asthma model. , 2003, The American journal of pathology.

[101]  C. Plopper,et al.  CELLULAR AND MOLECULAR CHARACTERISTICS OF BASAL CELLS IN AIRWAY EPITHELIUM , 2001, Experimental lung research.

[102]  C. Plopper,et al.  CELLULAR AND MOLECULAR CHARACTERISTICS OF BASAL CELLS IN AIRWAY EPITHELIUM , 2001 .

[103]  R Montironi,et al.  p63 is a prostate basal cell marker and is required for prostate development. , 2000, The American journal of pathology.

[104]  A. Glick,et al.  Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. , 2000, The Journal of investigative dermatology.

[105]  E. Fuchs,et al.  The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[106]  A. Paterson,et al.  Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice , 1999, Oncogene.

[107]  Christopher P. Crum,et al.  p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development , 1999, Nature.

[108]  H. Vogel,et al.  p63 is a p53 homologue required for limb and epidermal morphogenesis , 1999, Nature.

[109]  A. Yang,et al.  p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. , 1998, Molecular cell.

[110]  A. Ambergen,et al.  Number and proliferation of basal and parabasal cells in normal human airway epithelium. , 1998, American journal of respiratory and critical care medicine.

[111]  F. Sundler,et al.  Epithelial barrier formation by airway basal cells. , 1997, Thorax.

[112]  C. Plopper,et al.  Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice. , 1995, The American journal of physiology.

[113]  R. Cox,et al.  The role of basal cells in attachment of columnar cells to the basal lamina of the trachea. , 1989, American journal of respiratory cell and molecular biology.

[114]  S. Randell,et al.  Evidence for stem-cell niches in the tracheal epithelium. , 2001, American journal of respiratory cell and molecular biology.

[115]  D. Bowden.  Cell turnover in the lung. , 1983, The American review of respiratory disease.

[116]  S. Kauffman.  Cell proliferation in the mammalian lung. , 1980, International review of experimental pathology.