What We Know.

What We KnoW The COVID-19 pandemic is unprecedented. The last pandemic flu was in 1918–1919, which affected over 500 million people, causing 50 million deaths. However, as today’s pandemic is in a different era, the strategy has to be planned and executed in a different manner. The health, economic, and social implications all over the world are enormous as we are living and working in a highly advanced technological era with widespread global connectivity. The impact of COVID-19 has dealt blow on personal, family, and professional duties, causing profound disruption. On the contrary, there exists global confusion regarding the understanding of viral pathophysiology, testing, and treatment protocols. Till date, due to the different mutant strains of the virus, the clinical manifestation has varied from asymptomatic, mild fever with sore throat, dry cough to pneumonia and severe respiratory distress syndrome. It is also known to promote and cause thrombosis of blood vessels, leading to myocardial infarction and stroke. There is no possible cure for this viral infection but social distancing, maintaining hand hygiene, and properly worn masks have been able to control the spread of the disease. Several pharmacologic therapeutics, including antiviral agents, antibiotics, anti-inflammatory drugs, steroids, and immunosuppressive drugs, have been incorporated into treatment protocols on the basis of past experiences as well as trial and error basis. There is poor information about the possibility of relapses following primary infection. There is no effective vaccine in sight.