The PROSITE database, its status in 1997

The PROSITE database (http://www.expasy.ch/sprot/prosite.htm l) consists of biologically significant patterns and profiles formulated in such a way that with appropriate computational tools it can help to determine to which known family of protein (if any) a new sequence belongs, or which known domain(s) it contains.

[1]  Petra Mutzel,et al.  Computational Molecular Biology , 1996 .

[2]  A. Bairoch,et al.  PROSITE: recent developments. , 1994, Nucleic acids research.

[3]  S. Eddy.  Hidden Markov models. , 1996, Current opinion in structural biology.

[4]  S. Henikoff,et al.  Automated assembly of protein blocks for database searching. , 1991, Nucleic acids research.

[5]  Amos Bairoch,et al.  The PROSITE database, its status in 1995 , 1996, Nucleic Acids Res..

[6]  P. Bucher,et al.  Improving the sensitivity of the sequence profile method , 1994, Protein science : a publication of the Protein Society.

[7]  Russ Altman.  ISMB-94 : proceedings : second International Conference on Intelligent Systems for Molecular Biology , 1994 .

[8]  A. D. McLachlan,et al.  Profile analysis: detection of distantly related proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Kevin Karplus,et al.  A Flexible Motif Search Technique Based on Generalized Profiles , 1996, Comput. Chem..

[10]  R. Doolittle.  Of urfs and orfs : a primer on how to analyze devised amino acid sequences , 1986 .

[11]  S Henikoff,et al.  Sequence analysis by electronic mail server. , 1993, Trends in biochemical sciences.

[12]  Julie Dawn Thompson,et al.  Improved sensitivity of profile searches through the use of sequence weights and gap excision , 1994, Comput. Appl. Biosci..

[13]  M. Gribskov,et al.  [9] Profile analysis , 1990 .

[14]  Rolf Apweiler,et al.  The SWISS-PROT protein sequence data bank and its new supplement TREMBL , 1996, Nucleic Acids Res..

[15]  Patricia Rodriguez-Tomé,et al.  The European Bioinformatics Institute (EBI) databases , 1994, Nucleic Acids Res..

[16]  M Kanehisa,et al.  Construction of a dictionary of sequence motifs that characterize groups of related proteins , 1992, Protein engineering.

[17]  R D Appel,et al.  A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server. , 1994, Trends in biochemical sciences.