Global commercialization and research of veterinary vaccines against Pasteurella multocida: 2015–2022 technological surveillance

Background and Aim: Pasteurella multocida can infect a multitude of wild and domesticated animals, bacterial vaccines have become a crucial tool in combating antimicrobial resistance (AMR) in animal production. The study aimed to evaluate the current status and scientific trends related to veterinary vaccines against Pasteurella multocida during the 2015–2022 period. Materials and Methods: The characteristics of globally marketed vaccines were investigated based on the official websites of 22 pharmaceutical companies. VOSviewer® 1.6.18 was used to visualize networks of coauthorship and cooccurrence of keywords from papers published in English and available in Scopus. Results: Current commercial vaccines are mostly inactivated (81.7%), adjuvanted in aluminum hydroxide (57.8%), and designed to immunize cattle (33.0%). Investigational vaccines prioritize the inclusion of attenuated strains, peptide fragments, recombinant proteins, DNA as antigens, aluminum compounds as adjuvants and poultry as the target species. Conclusion: Despite advances in genetic engineering and biotechnology, there will be no changes in the commercial dominance of inactivated and aluminum hydroxide-adjuvanted vaccines in the short term (3–5 years). The future prospects for bacterial vaccines in animal production are promising, with advancements in vaccine formulation and genetic engineering, they have the potential to improve the sustainability of the industry. It is necessary to continue with the studies to improve the efficacy of the vaccines and their availability. Keywords: adjuvant, Pasteurella multocida, strain, technological surveillance, vaccine.

[1]  N. Rezaei,et al.  Immunogenicity of Different Types of Adjuvants and Nano-Adjuvants in Veterinary Vaccines: A Comprehensive Review , 2023, Vaccines.

[2]  G. Meyer,et al.  Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence , 2022, Veterinary Research.

[3]  O. Pérez,et al.  Technology surveillance in veterinary vaccine adjuvants (2015-2022): University-industry interaction , 2022, Journal of Pharmacy & Pharmacognosy Research.

[4]  S. Tamuly,et al.  Immunopotential of Pasteurella multocida bivalent outer membrane protein-based vaccine entrapped in aluminum hydroxide nanoparticles , 2022, Brazilian Journal of Microbiology.

[5]  I. Jahid,et al.  Multi-strain Probiotics Upregulated Anti-inflammatory Properties and Reduced Pasteurella multocida Mortality in Broilers , 2022, International Journal of Infectious Diseases.

[6]  R. Yogisharadhya,et al.  Comparative genome analysis of Pasteurella multocida serogroup B:2 strains causing Haemorrhagic septicaemia (HS) in bovines. , 2022, Gene.

[7]  A. Al-Gheethi,et al.  Spatial, Temporal, and Demographic Patterns in the Prevalence of Hemorrhagic Septicemia in 41 Countries in 2005–2019: A Systematic Analysis with Special Focus on the Potential Development of a New-Generation Vaccine , 2022, Vaccines.

[8]  Supervivencia de Pasteurella multocida aislada de conejo a la lisis inducida por el sistema complemento , 2022, Abanico Veterinario.

[9]  Oleksandra Silayeva,et al.  Autogenous vaccination in aquaculture: A locally enabled solution towards reduction of the global antimicrobial resistance problem , 2021, Reviews in Aquaculture.

[10]  W. Liang,et al.  Pasteurella multocida capsular: lipopolysaccharide types D:L6 and A:L3 remain to be the main epidemic genotypes of pigs in China , 2021, Animal Diseases.

[11]  Zhan-Qin Zhao,et al.  Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice , 2021, Vaccines.

[12]  Q. Xie,et al.  Characterization of Pasteurella multocida isolated from ducks in China from 2017 to 2019. , 2021, Microbial pathogenesis.

[13]  C. Ewers,et al.  Re-Emergence and Spread of Haemorrhagic Septicaemia in Germany: The Wolf as a Vector? , 2021, Microorganisms.

[14]  A. Ibrahim,et al.  Prevalence and Antimicrobial Susceptibility Profiles of Pasteurella multocida in Village Chickens (Gallus gallus domesticus) in Maiduguri, Borno State, Nigeria , 2021, American Journal of Biomedical and Life Sciences.

[15]  K. Alfson,et al.  Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences , 2021, Animals : an open access journal from MDPI.

[16]  A. Yassein,et al.  The immune response and protective efficacy of a potential DNA vaccine against virulent Pasteurella multocida , 2021, Journal of Genetic Engineering and Biotechnology.

[17]  Yi-Ting Lo,et al.  Cross-protection of recombinant Pasteurella multocida toxin proteins against atrophic rhinitis in mice. , 2021, Research in veterinary science.

[18]  C. Kyriakis,et al.  Novel Vaccine Technologies in Veterinary Medicine: A Herald to Human Medicine Vaccines , 2021, Frontiers in Veterinary Science.

[19]  S. L. Cosby,et al.  The Bacterial and Viral Agents of BRDC: Immune Evasion and Vaccine Developments , 2021, Vaccines.

[20]  A. Mostafa,et al.  Molecular Studies on Pasteurella multocida in Ducks , 2021 .

[21]  R. Jia,et al.  The lipopolysaccharide outer core transferase genes pcgD and hptE contribute differently to the virulence of Pasteurella multocida in ducks , 2021, Veterinary Research.

[22]  R. Rahim,et al.  Molecular Characterisation of the GdhA- Derivative of Pasteurella multocida B:2 , 2021 .

[23]  R. Rappuoli,et al.  The role of vaccines in combatting antimicrobial resistance , 2021, Nature Reviews Microbiology.

[24]  B. Bhanderi,et al.  Multilocus Sequence Typing of Pasturella multocida Isolates from Different Animal Species , 2021, THE INDIAN JOURNAL OF VETERINARY SCIENCES AND BIOTECHNOLOGY.

[25]  M. Yami,et al.  Phenotypic and Molecular Characterization of the Capsular Serotypes of Pasteurella multocida Isolated from Pneumonic Cases of Cattle in Ethiopia , 2021, Agricultural Science Digest - A Research Journal.

[26]  A. Bagcigil,et al.  Characterization of Pasteurella multocida isolates recovered from the oral flora of cats , 2020 .

[27]  M. Shokrgozar,et al.  PlpE Epitopes of Pasteurella multocida Fusion Protein as Novel Subunit Vaccine Candidates , 2020, Advanced biomedical research.

[28]  P. Tankaew,et al.  An Intranasal Vaccination with a Recombinant Outer Membrane Protein H against Haemorrhagic Septicemia in Swamp Buffaloes , 2020, Veterinary medicine international.

[29]  H. Vu-Khac,et al.  Prevalence of virulence factor, antibiotic resistance, and serotype genes of Pasteurella multocida strains isolated from pigs in Vietnam , 2020, Veterinary world.

[30]  V. Azevedo,et al.  Pathogenomics insights for understanding Pasteurella multocida adaptation. , 2020, International journal of medical microbiology : IJMM.

[31]  C. Qin,et al.  Research Note: The immune enhancement ability of inulin on ptfA gene DNA vaccine of avian Pasteurella multocida , 2020, Poultry science.

[32]  H. Rothan,et al.  Potential DNA Vaccine for Haemorrhagic Septiceamia Disease , 2020, Molecular Biotechnology.

[33]  S. Beatson,et al.  Using genomics to understand inter- and intra- outbreak diversity of Pasteurella multocida isolates associated with fowl cholera in meat chickens , 2020, Microbial genomics.

[34]  J. M. Lomillos,et al.  Consumers’ Concerns and Perceptions of Farm Animal Welfare , 2020, Animals : an open access journal from MDPI.

[35]  I. Moussa,et al.  A novel bivalent Pasteurellosis-RHD vaccine candidate adjuvanted with Montanide ISA70 protects rabbits from lethal challenge , 2020, Saudi journal of biological sciences.

[36]  S. Ismail,et al.  Intranasal inoculation of recombinant DNA vaccine ABA392 against haemorrhagic septicaemia disease , 2019, Letters in applied microbiology.

[37]  Zhan-Qin Zhao,et al.  Biosynthesis and regulation mechanisms of the Pasteurella multocida capsule. , 2019, Research in veterinary science.

[38]  A. Leblond,et al.  Antimicrobial resistance of Pasteurella multocida isolated from diseased food-producing animals and pets. , 2019, Veterinary microbiology.

[39]  Jong Wan Kim,et al.  Characterisation of Pasteurella multocida isolates from pigs with pneumonia in Korea , 2019, BMC Veterinary Research.

[40]  F. Alustiza,et al.  Characterization and comparison of strains of Pasteurella multocida associated with cases of progressive atrophic rhinitis and porcine pneumonia in Argentina , 2019, Veterinary world.

[41]  D. Jolhe,et al.  Isolation and molecular characterization of Mannheimia haemolytica and Pasteurella multocida associated with pneumonia of goats in Chhattisgarh , 2019, Veterinary world.

[42]  R. Kock,et al.  Biological characterization of Pasteurella multocida present in the Saiga population , 2019, BMC Microbiology.

[43]  Qing Liu,et al.  Identification of Fur in Pasteurella multocida and the Potential of Its Mutant as an Attenuated Live Vaccine , 2019, Front. Vet. Sci..

[44]  Rino Rappuoli,et al.  Correlates of adjuvanticity: A review on adjuvants in licensed vaccines. , 2018, Seminars in immunology.

[45]  K. Hoelzer,et al.  Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions , 2018, Veterinary Research.

[46]  M. Kargar,et al.  Pasteurella multocida inactivated with ferric chloride and adjuvanted with bacterial DNA is a potent and efficacious vaccine in Balb/c mice , 2018, Journal of medical microbiology.

[47]  W. Liang,et al.  Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species , 2018, Front. Microbiol..

[48]  K. Nakamura,et al.  Bovine respiratory syncytial virus infection enhances Pasteurella multocida adherence on respiratory epithelial cells , 2018, Veterinary Microbiology.

[49]  B. Charleston,et al.  Recent advances in veterinary applications of structural vaccinology , 2018, Current opinion in virology.

[50]  M. Ducatez,et al.  Disclosing respiratory co-infections: a broad-range panel assay for avian respiratory pathogens on a nanofluidic PCR platform , 2018, Avian pathology : journal of the W.V.P.A.

[51]  P. Tankaew,et al.  Intranasal immunization with a recombinant outer membrane protein H based Haemorrhagic septicemia vaccine in dairy calves , 2017, The Journal of veterinary medical science.

[52]  Hongbo Zhou,et al.  Identification and characterization of a protective antigen, PlpB of bovine Pasteurella multocida strain LZ‐PM , 2017, Developmental and comparative immunology.

[53]  L. Maturrano,et al.  Detection and genetic characterization of Pasteurella multocida from alpaca (Vicugna pacos) pneumonia cases , 2017, Tropical Animal Health and Production.

[54]  N. Mohanty,et al.  Immunogenicity of recombinant Omp16 protein of Pasteurella multocida B:2 in mouse model , 2017, The Indian Journal of Animal Sciences.

[55]  S. More,et al.  Pathogens, patterns of pneumonia, and epidemiologic risk factors associated with respiratory disease in recently weaned cattle in Ireland , 2017, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[56]  Shweta,et al.  Immunity against Pasteurella multocida in Animals Vaccinated with Inactivated Pasteurella multocida and Herbal Adjuvant 'DIP-HIP' , 2016 .

[57]  Qing Liu,et al.  Identification of the crp gene in avian Pasteurella multocida and evaluation of the effects of crp deletion on its phenotype, virulence and immunogenicity , 2016, BMC Microbiology.

[58]  H. Nathues,et al.  Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review , 2016, BMC Veterinary Research.

[59]  Md. Hafizur Rahman,et al.  Development of Experimental Oil based Inactivated HS Vaccine from field Isolates of Pasteurella multocida from Cattle in Bangladesh , 2016 .

[60]  M. Rahman,et al.  Isolation of Pasteurella multocida from chickens, preparation of formalin killed fowl cholera vaccine, and determination of efficacy in experimental chickens - , 2016 .

[61]  M. Qadeer,et al.  Haemorrhagic septicaemia outbreaks in cattle with high mortality following wrong vaccinations in Adamawa and Taraba States, Nigeria , 2016 .

[62]  T. Ghimire.  The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm , 2015, SpringerPlus.

[63]  N. Mohanty,et al.  Recombinant transferrin binding protein A (rTbpA) fragments of Pasteurella multocida serogroup B:2 provide variable protection following homologous challenge in mouse model. , 2015, Research in veterinary science.

[64]  H. Saxena,et al.  Estimation of titers of antibody against Pasteurella multocida in cattle vaccinated with haemorrhagic septicemia alum precipitated vaccine , 2014 .

[65]  A. D. De Groot,et al.  New vaccines needed for pathogens infecting animals and humans , 2012, Human vaccines & immunotherapeutics.

[66]  A. Petersen,et al.  Genetic diversity and associated pathology of Pasteurella multocida isolated from porcine pneumonia. , 2011, Veterinary microbiology.

[67]  S. B. Shivachandra,et al.  A review of hemorrhagic septicemia in cattle and buffalo , 2011, Animal Health Research Reviews.

[68]  D. S. McVey,et al.  Bacterial pathogens of the bovine respiratory disease complex. , 2010, The Veterinary clinics of North America. Food animal practice.

[69]  S. Robinson,et al.  Food Security: The Challenge of Feeding 9 Billion People , 2010, Science.

[70]  S. Abutarbush,et al.  Comparison of two multivalent viral vaccine programs in feedlot calves at high risk of developing undifferentiated fever/bovine respiratory disease , 2009, Bovine Practitioner.

[71]  N. Chanter,et al.  Veterinary vaccine development from an industrial perspective , 2008, The Veterinary Journal.

[72]  Ben Adler,et al.  Pasteurella multocida pathogenesis: 125 years after Pasteur. , 2006, FEMS microbiology letters.

[73]  A. Laishevtsev,et al.  Development and testing of a vaccine against infectious atrophic rhinitis and pasteurellosis in pigs , 2022, BIO Web of Conferences.

[74]  Investigation of the non-typical Pasteurella multocida strains obtained from multiple sources, regions, and times: An unexpected increase was detected , 2021, TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES.

[75]  Faisal,et al.  Molecular Detection and Characterization of Pasteurella multocida Isolated from Rabbits , 2021 .

[76]  Y. Yang,et al.  Construction of a ptfA chitosan nanoparticle DNA vaccine against Pasteurella multocida and the immune response in chickens. , 2018, Veterinary journal.

[77]  B. Kureljušić,et al.  Association between Pneumocystis spp. and co-infections with Bordetella bronchiseptica, Mycoplasma hyopneumoniae and Pasteurella multocida in Austrian pigs with pneumonia. , 2016, Veterinary journal.