Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion.
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[1] J. Auwerx,et al. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. , 2008, Cell metabolism.
[2] B. Manning,et al. The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid. , 2008, Molecular endocrinology.
[3] S. Woods,et al. The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity , 2008, The Journal of Neuroscience.
[4] J. Friedman,et al. Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism. , 2008, Experimental cell research.
[5] A. Pocai,et al. Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms , 2008, Nature Medicine.
[6] K. Kos,et al. Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass. , 2007, American journal of physiology. Endocrinology and metabolism.
[7] Jason U Tilan,et al. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome , 2007, Nature Medicine.
[8] R. Eckel,et al. CD36-Facilitated Fatty Acid Uptake Inhibits Leptin Production and Signaling in Adipose Tissue , 2007, Diabetes.
[9] Ke Chen,et al. Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes. , 2007, The Biochemical journal.
[10] J. Balschi,et al. Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes. , 2007, The Biochemical journal.
[11] P. Scherer,et al. Secretion of the Adipocyte-Specific Secretory Protein Adiponectin Critically Depends on Thiol-Mediated Protein Retention , 2007, Molecular and Cellular Biology.
[12] C. Russell,et al. Acute and chronic regulation of leptin synthesis, storage, and secretion by insulin and dexamethasone in human adipose tissue. , 2007, American journal of physiology. Endocrinology and metabolism.
[13] N. Sonenberg,et al. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. , 2007, The Journal of clinical investigation.
[14] S. Fried,et al. Feeding and Insulin Increase Leptin Translation , 2007, Journal of Biological Chemistry.
[15] U. Atasoy,et al. The regulation of glucose transporter (GLUT1) expression by the RNA binding protein HuR , 2006, Journal of cellular biochemistry.
[16] C. Lynch,et al. Leucine in food mediates some of the postprandial rise in plasma leptin concentrations. , 2006, American journal of physiology. Endocrinology and metabolism.
[17] S. Fried,et al. Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue Published, JLR Papers in Press, May 31, 2006. , 2006, Journal of Lipid Research.
[18] Bohan Wang,et al. Acute and prolonged effects of TNF-α on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture , 2006, Pflügers Archiv.
[19] M. Hall,et al. TOR Signaling in Growth and Metabolism , 2006, Cell.
[20] S. Heymsfield,et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. , 2005, The Journal of clinical investigation.
[21] Y. Deshaies,et al. Regulation of leptin secretion from white adipocytes by insulin, glycolytic substrates, and amino acids. , 2005, American journal of physiology. Endocrinology and metabolism.
[22] M. G. Dube,et al. High-fat diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats. , 2005, Obesity research.
[23] S. Schneider,et al. Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms. , 2005, American journal of physiology. Endocrinology and metabolism.
[24] M. Suchard,et al. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[25] B. Sancak,et al. Effects of PPARgamma and PPARalpha agonists on serum leptin levels in diet-induced obese rats. , 2004, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[26] M. Birnbaum,et al. Role of AMP-activated Protein Kinase in Cyclic AMP-dependent Lipolysis In 3T3-L1 Adipocytes* , 2003, Journal of Biological Chemistry.
[27] P. Garcia-Lorda,et al. Intralipid/heparin infusion suppresses serum leptin in humans. , 2003, European Journal of Endocrinology.
[28] Y. Deshaies,et al. Regulation of leptin secretion from white adipocytes by free fatty acids. , 2003, American journal of physiology. Endocrinology and metabolism.
[29] A. Tzatsos,et al. Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes. , 2003, American journal of physiology. Endocrinology and metabolism.
[30] N. Kimura,et al. A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway , 2003, Genes to cells : devoted to molecular & cellular mechanisms.
[31] H. Ueki,et al. Orthovanadate decreases the leptin content in isolated mouse fat pads via proteasome activation. , 2002, Archives of biochemistry and biophysics.
[32] S. Zolotukhin,et al. Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of beta3-adrenergic agonists, retinoic acid, leptin and fasting. , 2002, Biochimica et biophysica acta.
[33] L. Jefferson,et al. Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. , 2002, American journal of physiology. Endocrinology and metabolism.
[34] B. Cheatham,et al. Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes. , 2002, American journal of physiology. Endocrinology and metabolism.
[35] F. Pi‐Sunyer,et al. A pulse of insulin and dexamethasone stimulates serum leptin in fasting human subjects. , 2002, European journal of endocrinology.
[36] Rodney W. Johnson,et al. Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-α , 2002 .
[37] S. Kalra,et al. Ghrelin and leptin pulse discharge in fed and fasted rats. , 2002, Endocrinology.
[38] V. Kruys,et al. AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors. , 2001, Biochemical Society transactions.
[39] C. Deng,et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[40] M. Moreno-Aliaga,et al. Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3t3-l1 adipocytes. , 2001, Biochemical and biophysical research communications.
[41] C. Russell,et al. Regulation of the leptin content of obese human adipose tissue. , 2001, American journal of physiology. Endocrinology and metabolism.
[42] P. Trayhurn,et al. Regulation of leptin production: sympathetic nervous system interactions , 2001, Journal of Molecular Medicine.
[43] C. Russell,et al. Regulation of leptin production in humans. , 2000, The Journal of nutrition.
[44] B. Cheatham,et al. Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes. , 2000, Diabetes.
[45] P. Casellas,et al. Characterization of NPY receptors controlling lipolysis and leptin secretion in human adipocytes , 2000, FEBS letters.
[46] R. Adler,et al. Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway. , 2000, American journal of physiology. Endocrinology and metabolism.
[47] K. Nakao,et al. Downregulation of leptin by free fatty acids in rat adipocytes: effects of triacsin C, palmitate, and 2-bromopalmitate. , 2000, Metabolism: clinical and experimental.
[48] H. Lodish,et al. Two Compartments for Insulin-Stimulated Exocytosis in 3t3-L1 Adipocytes Defined by Endogenous Acrp30 and Glut4 , 1999, The Journal of cell biology.
[49] N. Barzilai,et al. The effect of leptin on Lep expression is tissue-specific and nutritionally regulated , 1999, Nature Medicine.
[50] G. Boden,et al. 15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene. , 1999, Metabolism: clinical and experimental.
[51] S. Fried,et al. Isoproterenol decreases leptin expression in adipose tissue of obese humans. , 1999, Obesity research.
[52] Barbara J. Reaves,et al. Truncated Human Leptin (Δ133) Associated with Extreme Obesity Undergoes Proteasomal Degradation after Defective Intracellular Transport. , 1999, Endocrinology.
[53] B. Cheatham,et al. Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes. , 1999, Diabetes.
[54] J. Lawrence,et al. Attenuation of Mammalian Target of Rapamycin Activity by Increased cAMP in 3T3-L1 Adipocytes* , 1998, The Journal of Biological Chemistry.
[55] R. Busse,et al. Leptin, the product of Ob gene, promotes angiogenesis. , 1998, Circulation research.
[56] J. Newcomer,et al. Dose-dependent cortisol-induced increases in plasma leptin concentration in healthy humans. , 1998, Archives of general psychiatry.
[57] L. Slieker,et al. Differentiation method-dependent expression of leptin in adipocyte cell lines. , 1998, Biochemical and biophysical research communications.
[58] J. Thornton,et al. Synergistic effects of feeding and dexamethasone on serum leptin levels. , 1998, The Journal of clinical endocrinology and metabolism.
[59] C. Russell,et al. Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone. , 1998, The American journal of physiology.
[60] F. Casanueva,et al. Acute changes in free-fatty acids (FFA) do not alter serum leptin levels , 1998, Journal of endocrinological investigation.
[61] C. Mobbs,et al. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. , 1998, Endocrinology.
[62] T. Kowalski,et al. The leptin receptor mediates apparent autocrine regulation of leptin gene expression. , 1997, Biochemical and biophysical research communications.
[63] V. Barr,et al. Insulin stimulates both leptin secretion and production by rat white adipose tissue. , 1997, Endocrinology.
[64] S. O’Rahilly,et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.
[65] H. Li,et al. beta 3-Adrenergic-mediated suppression of leptin gene expression in rats. , 1997, The American journal of physiology.
[66] C. Mantzoros,et al. Human leptin levels are pulsatile and inversely related to pituitary–ardenal function , 1997, Nature Medicine.
[67] S. Schneider,et al. Dexamethasone increases leptin expression in humans in vivo. , 1997, The Journal of clinical endocrinology and metabolism.
[68] S. Mandrup,et al. Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[69] B. Spiegelman,et al. Functional Antagonism between CCAAT/Enhancer Binding Protein-α and Peroxisome Proliferator-activated Receptor-γ on the Leptin Promoter* , 1997, The Journal of Biological Chemistry.
[70] B. Ahrén,et al. Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. , 1996, The Journal of clinical endocrinology and metabolism.
[71] J. Lawrence,et al. Control of the Translational Regulators PHAS-I and PHAS-II by Insulin and cAMP in 3T3-L1 Adipocytes* , 1996, The Journal of Biological Chemistry.
[72] B. Bennett,et al. A role for leptin and its cognate receptor in hematopoiesis , 1996, Current Biology.
[73] P. Watson,et al. The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. , 1996, Endocrinology.
[74] J. Auwerx,et al. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. , 1996, The Journal of clinical investigation.
[75] C. Mantzoros,et al. Role of leptin in the neuroendocrine response to fasting , 1996, Nature.
[76] R. Harris,et al. Early and late stimulation of ob mRNA expression in meal-fed and overfed rats. , 1996, The Journal of clinical investigation.
[77] L. Slieker,et al. Regulation of Expression of ob mRNA and Protein by Glucocorticoids and cAMP (*) , 1996, The Journal of Biological Chemistry.
[78] B. Weintraub,et al. Genomic Structure and Promoter Analysis of the Human obese Gene (*) , 1996, The Journal of Biological Chemistry.
[79] M. Chiesi,et al. Regulation of ob gene mRNA levels in cultured adipocytes , 1996, FEBS letters.
[80] D. Zheng,et al. Differential expression of ob mRNA in rat adipose tissues in response to insulin. , 1996, Biochemical and biophysical research communications.
[81] E. Ravussin,et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects , 1995, Nature Medicine.
[82] J. Auwerx,et al. Transient increase in obese gene expression after food intake or insulin administration , 1995, Nature.
[83] O. MacDougald,et al. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[84] F. Lönnqvist,et al. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects , 1995, Nature Medicine.
[85] E. Krebs,et al. cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[86] M. Maffei,et al. Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.
[87] S. Schneider,et al. Tumor necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase. , 2006, The Journal of clinical endocrinology and metabolism.
[88] Rodney W. Johnson,et al. Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha. , 2002, American Journal of Physiology. Regulatory Integrative and Comparative Physiology.
[89] Claude Bouchard,et al. Plasma leptin response to an epinephrine infusion in lean and obese women. , 2002, Obesity research.
[90] H. Rau,et al. Truncated human leptin (delta133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport. , 1999, Endocrinology.
[91] A. Barthel,et al. A constitutively active version of the Ser/Thr kinase Akt induces production of the ob gene product, leptin, in 3T3-L1 adipocytes. , 1997, Endocrinology.
[92] M. Maffei,et al. Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.
[93] K. Kandror,et al. Identification and characterization of leptin-containing intracellular compartment in rat adipose cells , 2022 .
[94] J. Levy,et al. Printed in U.S.A. Copyright © 2001 by The Endocrine Society The Effects of Insulin, Glucose, and Pyruvate on the Kinetics of Leptin Secretion , 2022 .
[95] S. Schneider,et al. 0021-972X/04/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 89(11):5577–5582 Printed in U.S.A. Copyright © 2004 by The Endocrine Society doi: 10.1210/jc.2004-0603 Interleukin-6 Regulates Human Adipose Tissue Lipid Metabolism and Leptin Produc , 2022 .