Iodine-Promoted Domino Reactions of 1-Cyanocyclopropane 1-Esters: A Straightforward Approach to Fully Substituted 2-Aminofurans

A straightforward and efficient iodine-promoted ring-opening/cyclization domino reaction of 1-cyanocyclopropane 1-esters for the synthesis of fully substituted 2-aminofurans is reported. This reaction involves the sequential ring-opening/intramolecular cyclization reaction of 1-cyanocyclopropane 1-esters to give the corresponding 2-amino-4,5-dihydrofurans, which were oxidized with I2 and Et3N in refluxing toluene to give the corresponding 2-amino-3-furancarboxylates.

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