Evaluation of nootropic potential of Ocimum sanctum Linn. in mice.

Dementia is one of the age related mental problems and a characteristic symptom of various neurodegenerative disorders including Alzheimer's disease. Certain drugs like diazepam, barbiturates and alcohol disrupt learning and memory in animals and man. However, a new class of drugs known as nootropic agents is now used in situations where there is organic disorder in learning abilities. The present work was undertaken to assess the potential of O. sanctum extract as a nootropic and anti-amnesic agent in mice. Aqueous extract of dried whole plant of O. sanctum ameliorated the amnesic effect of scopolamine (0.4 mg/kg), diazepam (1 mg/kg) and aging induced memory deficits in mice. Elevated plus maze and passive avoidance paradigm served as the exteroceptive behavioral models. O. sanctum extract decreased transfer latency and increased step down latency, when compared to control (piracetam treated), scopolamine and aged groups of mice significantly. O. sanctum preparations could of beneficial in the treatment of cognitive disorders such as dementia and Alzheimer's disease.

[1]  H. Joshi,et al.  Effects of piperine on memory and behavior mediated via monoamine neurotransmiters , 2005 .

[2]  R. Petersen.  Mild cognitive impairment as a diagnostic entity , 2004, Journal of internal medicine.

[3]  S. Kulkarni,et al.  Improvement of mouse memory by Myristica fragrans seeds. , 2004, Journal of medicinal food.

[4]  S. Srivastava,et al.  Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. , 2004, Journal of ethnopharmacology.

[5]  S. Kulkarni,et al.  Memory enhancing activity of Glycyrrhiza glabra in mice. , 2004, Journal of ethnopharmacology.

[6]  R. K. Jaggi,et al.  Anticonvulsant potential of holy basil, Ocimum sanctum Linn., and its cultures. , 2003, Indian journal of experimental biology.

[7]  J. Bhatia,et al.  Antinociceptive action of Ocimum sanctum (Tulsi) in mice: possible mechanisms involved. , 2003, Journal of ethnopharmacology.

[8]  S. Davis,et al.  Learning deficits and dysfunctional synaptic plasticity induced by aggregated amyloid deposits in the dentate gyrus are rescued by chronic treatment with indomethacin , 2003, The European journal of neuroscience.

[9]  V. Kasture,et al.  Nootropic activity of Albizzia lebbeck in mice. , 2002, Journal of ethnopharmacology.

[10]  S. Srivastava,et al.  Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. , 2002, Indian journal of experimental biology.

[11]  C. Andrade,et al.  Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats , 2002, Biological Psychiatry.

[12]  P. Mediratta,et al.  Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. , 2002, Journal of ethnopharmacology.

[13]  J. Prakash,et al.  Chemopreventive activity of Ocimum sanctum seed oil. , 2000, Journal of ethnopharmacology.

[14]  S. Mandal,et al.  Effect of Ocimum sanctum roots extract on swimming performance in mice , 2000, Phytotherapy research : PTR.

[15]  M. Nair,et al.  Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. , 2000, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[16]  R. Mohs,et al.  A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease , 1998, Neurology.

[17]  S. Bhattacharya,et al.  Effect of piracetam on electroshock induced amnesia and decrease in brain acetylcholine in rats. , 1993, Indian journal of experimental biology.

[18]  S. Godhwani,et al.  Ocimum sanctum: an experimental study evaluating its anti-inflammatory, analgesic and antipyretic activity in animals. , 1987, Journal of ethnopharmacology.

[19]  J. Grover,et al.  Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. , 2004, Journal of ethnopharmacology.

[20]  Yuan Luo,et al.  Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761. , 2003, Journal of Alzheimer's disease : JAD.

[21]  S. Bhattacharya,et al.  Further Investigations on the Antioxidant Activity of Ocimum sanctum Using Different Paradigms of Oxidative Stress in Rats , 2001 .

[22]  P. Uma Devi.  Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum sanctum (Tulasi). , 2001, Indian journal of experimental biology.

[23]  I. Nagy.  On the true role of oxygen free radicals in the living state, aging, and degenerative disorders. , 2001, Annals of the New York Academy of Sciences.

[24]  Rachelle S. Doody,et al.  DONEPEZIL STUDY GROUP. A 24-WEEK, DOUBLE BLIND, PLACEBO-CONTROLLED TRIAL OF DONEPEZIL IN PATIENTS WITH ALZHEIMER'S DIS-EASE , 1998 .

[25]  J. Pan,et al.  [Antagonism of piracetam on the amnestic effect of diazepam in mice]. , 1996, Yao xue xue bao = Acta pharmaceutica Sinica.

[26]  T. Kameyama,et al.  UTILITY OF AN ELEVATED PLUS MAZE FOR THE EVALUATION OF NOOTROPICS, SCOPOLAMINE AND ELECTRO CONVULSIVE SHOCK , 1990 .

[27]  S. Iversen,et al.  Handbook of Psychopharmacology , 1988, Springer US.