C16‐methyl corticosteroids are far less allergenic than the non‐methylated molecules

Background. It has been confirmed that binding to amino acids in skin proteins takes place at C21 after oxidation of the corticosteroid molecule, which gives to the constituents of the D‐ring an essential role in cross‐reactivity patterns. In 2000, Matura et al. subdivided the corticosteroid esters of the D‐group into two subgroups: D1, the ‘stable’ esters; and D2, the ‘labile’ esters. Recent data have indicated that non‐methylated corticosteroids selectively react with arginine to form stable cyclic adducts, which are probably implicated in sensitization to corticosteroids.

[1]  A. Goossens,et al.  Delayed hypersensitivity to corticosteroids in a series of 315 patients: clinical data and patch test results , 2009, Contact dermatitis.

[2]  C. Pilette,et al.  Allergic hypersensitivity to topical and systemic corticosteroids: a review , 2009, Allergy.

[3]  Antonio Prado Moreno,et al.  Vlerick Leuven Gent Working Paper Series 2003/22 Starting Resource Configurations of Research-based Start-ups and the Interaction with Technology , 2022 .

[4]  C. Thompson.  New topical corticosteroid treats postoperative ocular pain. , 2008, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[5]  Emilie Claudel.  Allergie de contact aux corticostéroïdes : Synthèse de métabolites marqués au carbone 13 et étude par RMN de leurs interactions avec les protéines , 2008 .

[6]  M. Beck,et al.  Comparative testing with budesonide in petrolatum and ethanol in a standard series , 2002, Contact dermatitis.

[7]  A. Goossens,et al.  Recommendation to include budesonide and tixocortol pivalate in the European standard series. ESCD and EECDRG. European Society of Contact Dermatitis. , 2000, Contact dermatitis.

[8]  S. M. Wilkinson.  Corticosteroid cross‐reactions: an alternative view , 2000, Contact dermatitis.

[9]  M. Bruze,et al.  The benefit of patch testing with a corticosteroid at a low concentration. , 1999, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

[10]  A. Goossens,et al.  Patch testing with budesonide in serial dilutions: the significance of dose, occlusion time and reading time * , 1999, Contact dermatitis.

[11]  S. M. Wilkinson,et al.  Corticosteroid usage and binding to arginine: determinants of corticosteroid hypersensitivity , 1996, The British journal of dermatology.

[12]  M. Beck,et al.  Corticosteroid contact hypersensitivity: what vehicle and concentration? , 1996, Contact dermatitis.

[13]  J. Lepoittevin,et al.  Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids. , 1995, Archives of dermatology.

[14]  L. Kanerva,et al.  CONTACT ALLERGY TO CORTICOSTEROIDS , 1996, Journal of the American Academy of Dermatology.

[15]  M. Rothe.  Coopman S, Degreef H, Dooms-Goossens A: Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. , 1990 .

[16]  H. Degreef,et al.  Identification of cross‐reaction patterns in allergic contact dermatitis from topical corticosteroids , 1989, The British journal of dermatology.

[17]  Valentino J. Stella,et al.  Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists , 1979 .

[18]  D. London.  The corticosteroids. , 1968, The Practitioner.