Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

[1]  P. Tompa,et al.  Emergent functions of proteins in non-stoichiometric supramolecular assemblies. , 2019, Biochimica et biophysica acta. Proteins and proteomics.

[2]  E. C. Schirmer,et al.  Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity , 2019, Nature Communications.

[3]  O. Medalia,et al.  Insight into the functional organization of nuclear lamins in health and disease. , 2018, Current opinion in cell biology.

[4]  M. Buehler,et al.  The Rise of Hierarchical Nanostructured Materials from Renewable Sources: Learning from Nature. , 2018, ACS nano.

[5]  G. Stanley,et al.  Atomic force microscopy reveals structural variability amongst nuclear pore complexes , 2018, Life Science Alliance.

[6]  E. Peterman,et al.  Viscoelastic properties of vimentin originate from nonequilibrium conformational changes , 2018, Science Advances.

[7]  Caroline Uhler,et al.  Nuclear Mechanopathology and Cancer Diagnosis. , 2018, Trends in cancer.

[8]  D. Discher,et al.  Rupture Dynamics and Chromatin Herniation in Deformed Nuclei. , 2017, Biophysical journal.

[9]  J. Marko,et al.  Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus , 2017, Molecular biology of the cell.

[10]  Robert D. Goldman,et al.  The molecular architecture of lamins in somatic cells , 2017, Nature.

[11]  M. Radmacher,et al.  Mechanics in human fibroblasts and progeria: Lamin A mutation E145K results in stiffening of nuclei , 2017, Journal of molecular recognition : JMR.

[12]  E. Peterman,et al.  Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain. , 2017, Physical review letters.

[13]  Sjors H.W. Scheres,et al.  Helical reconstruction in RELION , 2016, bioRxiv.

[14]  Ignacio Pagonabarraga,et al.  Emergent structures and dynamics of cell colonies by contact inhibition of locomotion , 2016, Proceedings of the National Academy of Sciences.

[15]  Ueli Aebi,et al.  Intermediate Filaments: Structure and Assembly. , 2016, Cold Spring Harbor perspectives in biology.

[16]  M. Hetzer,et al.  Nuclear envelope rupture is induced by actin-based nucleus confinement , 2016, The Journal of cell biology.

[17]  Ning Wang,et al.  Transcription upregulation via force-induced direct stretching of chromatin , 2016, Nature materials.

[18]  Albert-Lszl Barabsi,et al.  Network Science , 2016, Encyclopedia of Big Data.

[19]  S. Ito,et al.  An Unroofing Method to Observe the Cytoskeleton Directly at Molecular Resolution Using Atomic Force Microscopy , 2016, Scientific Reports.

[20]  Jan Lammerding,et al.  Squish and squeeze-the nucleus as a physical barrier during migration in confined environments. , 2016, Current opinion in cell biology.

[21]  O. Medalia,et al.  Impaired mechanical response of an EDMD mutation leads to motility phenotypes that are repaired by loss of prenylation , 2016, Journal of Cell Science.

[22]  O. Medalia,et al.  Toward correlating structure and mechanics of platelets , 2016, Cell adhesion & migration.

[23]  Jan Lammerding,et al.  Nuclear envelope rupture and repair during cancer cell migration , 2016, Science.

[24]  Yixian Zheng,et al.  Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy , 2015, Molecular biology of the cell.

[25]  Daniel J. Müller,et al.  Mechanical control of mitotic progression in single animal cells , 2015, Proceedings of the National Academy of Sciences.

[26]  Anthony A Hyman,et al.  Emergent Properties of the Metaphase Spindle. , 2015, Cold Spring Harbor perspectives in biology.

[27]  O. Medalia,et al.  Structure and gating of the nuclear pore complex , 2015, Nature Communications.

[28]  R. Foisner,et al.  Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation. , 2015, Annual review of biochemistry.

[29]  Bianxiao Cui,et al.  Vertical nanopillars for in situ probing of nuclear mechanics in adherent cells. , 2015, Nature nanotechnology.

[30]  R. Dickinson,et al.  Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell , 2015, Proceedings of the National Academy of Sciences.

[31]  Hannah G. Yevick,et al.  Emergence of collective modes and tri-dimensional structures from epithelial confinement , 2014, Nature Communications.

[32]  Milica Radisic,et al.  In situ mechanical characterization of the cell nucleus by atomic force microscopy. , 2014, ACS nano.

[33]  Jan Lammerding,et al.  Broken nuclei--lamins, nuclear mechanics, and disease. , 2014, Trends in cell biology.

[34]  Richard Superfine,et al.  Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus , 2014, Nature Cell Biology.

[35]  J. Lammerding,et al.  Nuclear Mechanics and Mechanotransduction in Health and Disease , 2013, Current Biology.

[36]  Dennis E. Discher,et al.  Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation , 2013, Science.

[37]  Carolyn Kaut Roth,et al.  Data Acquisition and Processing , 2013 .

[38]  Allison Y. Hsiang,et al.  Evolutionary Origin of the Turtle Shell , 2013, Current Biology.

[39]  Katherine H. Schreiber,et al.  When Lamins Go Bad: Nuclear Structure and Disease , 2013, Cell.

[40]  Robert D. Goldman,et al.  Mechanical model of blebbing in nuclear lamin meshworks , 2013, Proceedings of the National Academy of Sciences.

[41]  F. Huber,et al.  Emergent complexity of the cytoskeleton: from single filaments to tissue , 2013, Advances in physics.

[42]  Olga Kononova,et al.  Mechanical transition from α-helical coiled coils to β-sheets in fibrin(ogen). , 2012, Journal of the American Chemical Society.

[43]  J. Weisel,et al.  The α-helix to β-sheet transition in stretched and compressed hydrated fibrin clots. , 2012, Biophysical journal.

[44]  S. Adam,et al.  Nuclear lamin functions and disease. , 2012, Trends in genetics : TIG.

[45]  Noah Linden,et al.  A de novo peptide hexamer with a mutable channel , 2011, Nature chemical biology.

[46]  Jan Lammerding,et al.  Nuclear mechanics in disease. , 2011, Annual review of biomedical engineering.

[47]  M. Radmacher,et al.  Amphibian oocyte nuclei expressing lamin A with the progeria mutation E145K exhibit an increased elastic modulus , 2011, Nucleus.

[48]  M. Buehler,et al.  Flaw tolerance of nuclear intermediate filament lamina under extreme mechanical deformation. , 2011, ACS nano.

[49]  Jan Lammerding,et al.  Nuclear mechanics during cell migration. , 2011, Current opinion in cell biology.

[50]  M. Buehler,et al.  Molecular dynamics simulation of the α-helix to β-sheet transition in coiled protein filaments: evidence for a critical filament length scale. , 2010, Physical review letters.

[51]  M. Goldberg,et al.  Oocytes as an experimental system to analyze the ultrastructure of endogenous and ectopically expressed nuclear envelope components by field-emission scanning electron microscopy. , 2010, Methods.

[52]  M. Buehler,et al.  Molecular Dynamics Simulation of the alpha-Helix to beta-Sheet Transition in Coiled Protein Filaments: Evidence for a Critical Filament Length Scale , 2010 .

[53]  Jan Ellenberg,et al.  Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin , 2009, The EMBO journal.

[54]  Markus J. Buehler,et al.  Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments , 2009, PloS one.

[55]  Markus J Buehler,et al.  Nanomechanical properties of vimentin intermediate filament dimers , 2009, Nanotechnology.

[56]  O. Medalia,et al.  The supramolecular organization of the C. elegans nuclear lamin filament. , 2009, Journal of molecular biology.

[57]  Markus J Buehler,et al.  Deformation and failure of protein materials in physiologically extreme conditions and disease. , 2009, Nature materials.

[58]  U. Kutay,et al.  Orchestrating nuclear envelope disassembly and reassembly during mitosis , 2009, Nature Reviews Molecular Cell Biology.

[59]  J. B. Rattner,et al.  Tethering by lamin A stabilizes and targets the ING1 tumour suppressor , 2008, Nature Cell Biology.

[60]  G. Shivashankar,et al.  Dynamics of chromatin decondensation reveals the structural integrity of a mechanically prestressed nucleus. , 2008, Biophysical journal.

[61]  Hermann Schillers,et al.  Elasticity measurement of living cells with an atomic force microscope: data acquisition and processing , 2008, Pflügers Archiv - European Journal of Physiology.

[62]  Ueli Aebi,et al.  Tensile properties of single desmin intermediate filaments. , 2008, Biophysical journal.

[63]  Klaus Schulten,et al.  Molecular basis of fibrin clot elasticity. , 2008, Structure.

[64]  Ueli Aebi,et al.  Towards an integrated understanding of the structure and mechanics of the cell nucleus , 2008, BioEssays : news and reviews in molecular, cellular and developmental biology.

[65]  M. Goldberg,et al.  Filaments made from A- and B-type lamins differ in structure and organization , 2008, Journal of Cell Science.

[66]  R. Superfine,et al.  A Comparison of the Mechanical and Structural Properties of Fibrin Fibers with Other Protein Fibers , 2007, Cell Biochemistry and Biophysics.

[67]  M. Fornerod,et al.  The inner nuclear envelope as a transcription factor resting place , 2007, EMBO reports.

[68]  Markus J. Buehler,et al.  Fracture mechanics of protein materials , 2007 .

[69]  Peter Fratzl,et al.  Biomimetic materials research: what can we really learn from nature's structural materials? , 2007, Journal of The Royal Society Interface.

[70]  Ueli Aebi,et al.  Intermediate filaments: from cell architecture to nanomechanics , 2007, Nature Reviews Molecular Cell Biology.

[71]  J. Lammerding,et al.  Mechanical properties of the cell nucleus and the effect of emerin deficiency. , 2006, Biophysical journal.

[72]  Robert W. Cahn,et al.  Learning from nature , 2006, Nature.

[73]  Tom Misteli,et al.  Distinct structural and mechanical properties of the nuclear lamina in Hutchinson–Gilford progeria syndrome , 2006, Proceedings of the National Academy of Sciences.

[74]  U Aebi,et al.  Exploring the mechanical behavior of single intermediate filaments. , 2005, Journal of molecular biology.

[75]  D. Discher,et al.  Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. , 2005, Biophysical journal.

[76]  A. Rowat,et al.  Characterization of the elastic properties of the nuclear envelope , 2005, Journal of The Royal Society Interface.

[77]  D. Wirtz,et al.  Nuclear Envelope Breakdown Requires Overcoming the Mechanical Integrity of the Nuclear Lamina* , 2004, Journal of Biological Chemistry.

[78]  Howard J Worman,et al.  The nuclear envelope and human disease. , 2004, Physiology.

[79]  Dennis E Discher,et al.  The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber , 2004, Journal of Cell Science.

[80]  Laurent Kreplak,et al.  New Aspects of the α-Helix to β-Sheet Transition in Stretched Hard α-Keratin Fibers , 2004 .

[81]  P. Janmey,et al.  Nonlinear elasticity in biological gels , 2004, Nature.

[82]  Richard T. Lee,et al.  Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. , 2004, The Journal of clinical investigation.

[83]  R. Albert,et al.  Structural vulnerability of the North American power grid. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[84]  Christian Riekel,et al.  The mechanical properties of hydrated intermediate filaments: insights from hagfish slime threads. , 2003, Biophysical journal.

[85]  Matthias Rief,et al.  The myosin coiled-coil is a truly elastic protein structure , 2002, Nature materials.

[86]  C. Stewart,et al.  Life at the edge: the nuclear envelope and human disease , 2002, Nature Reviews Molecular Cell Biology.

[87]  Roland Eils,et al.  Nuclear Envelope Breakdown Proceeds by Microtubule-Induced Tearing of the Lamina , 2002, Cell.

[88]  C. Vigouroux,et al.  Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene. , 2001, Journal of cell science.

[89]  W. Surewicz,et al.  On the Mechanism of α-Helix to β-Sheet Transition in the Recombinant Prion Protein† , 2001 .

[90]  J. Gosline,et al.  The mechanical design of spider silks: from fibroin sequence to mechanical function. , 1999, The Journal of experimental biology.

[91]  J. Gosline,et al.  Molecular and mechanical design of spider's silks , 1999 .

[92]  M. Karplus,et al.  Effective energy function for proteins in solution , 1999, Proteins.

[93]  M. Rief,et al.  How strong is a covalent bond? , 1999, Science.

[94]  M. Peter,et al.  Expression of chicken lamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions , 1991, The Journal of cell biology.

[95]  R. Stick.  cDNA cloning of the developmentally regulated lamin LIII of Xenopus laevis. , 1988, The EMBO journal.

[96]  U. Aebi,et al.  The nuclear lamina is a meshwork of intermediate-type filaments , 1986, Nature.

[97]  K. Takano.  ON SOLUTION OF , 1983 .

[98]  G. Blobel,et al.  Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution , 1978, The Journal of cell biology.

[99]  E. Bendit.  A Quantitative X-Ray Diffraction Study of the Alpha-Beta Transformation in Wool Keratin , 1960 .

[100]  K. Bailey,et al.  Fibrinogen and Fibrin as Members of the Keratin-Myosin Group , 1943, Nature.

[101]  O. Medalia,et al.  Nuclear Lamins: Thin Filaments with Major Functions. , 2018, Trends in cell biology.

[102]  C. Hutchison.  Do lamins influence disease progression in cancer? , 2014, Advances in experimental medicine and biology.

[103]  O. Medalia,et al.  Filaments assembly of ectopically expressed Caenorhabditis elegans lamin within Xenopus oocytes. , 2012, Journal of structural biology.

[104]  L. Kreplak,et al.  New aspects of the alpha-helix to beta-sheet transition in stretched hard alpha-keratin fibers. , 2004, Biophysical journal.

[105]  W. Surewicz,et al.  On the mechanism of alpha-helix to beta-sheet transition in the recombinant prion protein. , 2001, Biochemistry.

[106]  U Aebi,et al.  Nuclear lamins: their structure, assembly, and interactions. , 1998, Journal of structural biology.

[107]  H. Fraenkel-conrat,et al.  Structure and Assembly , 1975, Comprehensive Virology.