Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

[1]  T. Quesada-López,et al.  CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation. , 2018, Cell metabolism.

[2]  M. Klingenspor,et al.  Brown adipocyte glucose metabolism: a heated subject , 2018, EMBO reports.

[3]  P. Nuutila,et al.  Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis. , 2018, Cell metabolism.

[4]  E. Lengyel,et al.  Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors. , 2018, Trends in cancer.

[5]  Jan Nedergaard,et al.  Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study , 2017, Molecular metabolism.

[6]  Amir I. Mina,et al.  Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. , 2017, Cell metabolism.

[7]  S. Kajimura,et al.  UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis , 2017, Nature Medicine.

[8]  B. Spiegelman,et al.  UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction , 2017, Proceedings of the National Academy of Sciences.

[9]  B. Spiegelman,et al.  Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. , 2017, Cell metabolism.

[10]  M. Schwaiger,et al.  Active Brown Fat During 18F-FDG PET/CT Imaging Defines a Patient Group with Characteristic Traits and an Increased Probability of Brown Fat Redetection , 2017, The Journal of Nuclear Medicine.

[11]  J. Blenis,et al.  The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue , 2016, Genes & development.

[12]  B. Wollscheid,et al.  Proteomic Analysis of Human Brown Adipose Tissue Reveals Utilization of Coupled and Uncoupled Energy Expenditure Pathways , 2016, Scientific Reports.

[13]  Joseph F. Clark,et al.  Creatine transporter deficiency leads to increased whole body and cellular metabolism , 2016, Amino Acids.

[14]  S. Maurya,et al.  Sarcolipin and uncoupling protein 1 play distinct roles in diet‐induced thermogenesis and do not compensate for one another , 2016, Obesity.

[15]  M. Scherrer-Crosbie,et al.  Relationship of brown adipose tissue perfusion and function: a study through β2-adrenoreceptor stimulation. , 2016, Journal of applied physiology.

[16]  G. Twig,et al.  Body-Mass Index in 2.3 Million Adolescents and Cardiovascular Death in Adulthood. , 2016, The New England journal of medicine.

[17]  S. Scafidi,et al.  Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality. , 2016, Cell reports.

[18]  B. Spiegelman,et al.  A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat , 2015, Cell.

[19]  Ingo Ruczinski,et al.  Detecting Significant Changes in Protein Abundance. , 2015, EuPA open proteomics.

[20]  Steven L Salzberg,et al.  HISAT: a fast spliced aligner with low memory requirements , 2015, Nature Methods.

[21]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[22]  J. Granneman,et al.  Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation , 2014, Journal of Lipid Research.

[23]  K. Walsh,et al.  Vascular rarefaction mediates whitening of brown fat in obesity. , 2014, The Journal of clinical investigation.

[24]  G. Montana,et al.  Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice , 2014, American journal of physiology. Endocrinology and metabolism.

[25]  Wei Shi,et al.  featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..

[26]  J. Speakman,et al.  Not so hot: Optimal housing temperatures for mice to mimic the thermal environment of humans. , 2013, Molecular metabolism.

[27]  Nicola Zamboni,et al.  High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry. , 2011, Analytical chemistry.

[28]  U. Klein,et al.  Transcriptional control of adipose lipid handling by IRF4. , 2011, Cell metabolism.

[29]  P. Svensson,et al.  Gene expression in human brown adipose tissue. , 2011, International journal of molecular medicine.

[30]  Joseph F. Clark,et al.  Creatine Transporter (CrT; Slc6a8) Knockout Mice as a Model of Human CrT Deficiency , 2011, PloS one.

[31]  Edward L. Huttlin,et al.  A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression , 2010, Cell.

[32]  F. Oerlemans,et al.  Mice lacking brain-type creatine kinase activity show defective thermoregulation , 2009, Physiology & Behavior.

[33]  Israel Steinfeld,et al.  BMC Bioinformatics BioMed Central , 2008 .

[34]  C. Stehouwer,et al.  Regulation of Vascular Function and Insulin Sensitivity by Adipose Tissue: Focus on Perivascular Adipose Tissue , 2007, Microcirculation.

[35]  Steven P Gygi,et al.  Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry , 2007, Nature Methods.

[36]  J. Ukropec,et al.  UCP1-independent Thermogenesis in White Adipose Tissue of Cold-acclimated Ucp1-/- Mice* , 2006, Journal of Biological Chemistry.

[37]  J. Speakman,et al.  The Functional Significance of Individual Variation in Basal Metabolic Rate , 2004, Physiological and Biochemical Zoology.

[38]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[39]  M. Rossmeisl,et al.  Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. , 2003, The Journal of clinical investigation.

[40]  T. Cole,et al.  Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and Cardiovascular Disease? , 2002, Circulation.

[41]  B. Lowell,et al.  βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance , 2002, Science.

[42]  L. Kozak,et al.  Effects of Genetic Background on Thermoregulation and Fatty Acid-induced Uncoupling of Mitochondria in UCP1-deficient Mice* , 2001, The Journal of Biological Chemistry.

[43]  D A Follmann,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans , 2022 .

[44]  N. Rothwell,et al.  A role for brown adipose tissue in diet-induced thermogenesis. , 1997, Nature.

[45]  Y. Ohira,et al.  Thermogenic responses to high-energy phosphate contents and/or hindlimb suspension in rats. , 1996, The Japanese journal of physiology.

[46]  T. Kizaki,et al.  Increased growth of brown adipose tissue but its reduced thermogenic activity in creatine-depleted rats fed beta-guanidinopropionic acid. , 1995, Biochimica et biophysica acta.

[47]  M. Dutia,et al.  Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. , 1992, Journal of medicinal chemistry.

[48]  B V Howard,et al.  Reduced rate of energy expenditure as a risk factor for body-weight gain. , 1988, The New England journal of medicine.

[49]  S. Hogan,et al.  Increased brown adipose tissue thermogenesis in obese (ob/ob) mice fed a palatable diet. , 1986, The American journal of physiology.

[50]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[51]  R. Leibel,et al.  Diminished energy requirements in reduced-obese patients. , 1984, Metabolism: clinical and experimental.

[52]  Michael J. Stock,et al.  A role for brown adipose tissue in diet-induced thermogenesis , 1979, Nature.

[53]  M. Barrand,et al.  Reduced thermogenesis in obesity , 1979, Nature.

[54]  H. Berlet,et al.  Occurrence of free creatine, phosphocreatine and creatine phosphokinase in adipose tissue. , 1976, Biochimica et biophysica acta.

[55]  W. F. Payne,et al.  Creatine metabolism in skeletal muscle. 3. Specificity of the creatine entry process. , 1968, The Journal of biological chemistry.

[56]  G. Dalrymple,et al.  Creatine metabolism in skeletal muscle , 1968, Neurology.

[57]  J. Silverman,et al.  The Institutional Animal Care and Use Committee , 2015 .

[58]  G. Montana,et al.  Intrinsic differences in gene expression and response to 5 cold exposure in mice , 2014 .

[59]  H. Laborit,et al.  [Experimental study]. , 1958, Bulletin mensuel - Societe de medecine militaire francaise.