Sex hormones, central nervous system and pain

The aim of the present review, which highlights some relationships between sex hormones, the CNS and pain, is to provide reference points for discussion on one of the most intriguing aspects of pain pathophysiology: the presence of sex differences in the response threshold to phasic painful stimuli and in the incidence of chronic pain syndromes. The first part of the review deals with sex steroids and their mechanisms of action. In the second part, the connections between sex steroids, the CNS and pain are illustrated to introduce possible areas of discussion in the study of sex differences in experimental and clinical pain.

[1]  T. Foster.  Interaction of rapid signal transduction cascades and gene expression in mediating estrogen effects on memory over the life span , 2005, Frontiers in Neuroendocrinology.

[2]  G. Debonnel,et al.  Oestrogen and Testosterone Modulate the Firing Activity of Dorsal Raphe Nucleus Serotonergic Neurones in Both Male and Female Rats , 2005, Journal of neuroendocrinology.

[3]  B. McEwen,et al.  Estrogen actions in the central nervous system. , 1999, Endocrine reviews.

[4]  M. Segal,et al.  Estradiol Increases Dendritic Spine Density by Reducing GABA Neurotransmission in Hippocampal Neurons , 1998, The Journal of Neuroscience.

[5]  C. Roselli,et al.  Regulation of Aromatase Gene Expression in the Adult Rat Brain , 1997, Brain Research Bulletin.

[6]  R. Steeds,et al.  Chronic Stable Angina : A Randomized , Double-Blind , Placebo-Controlled Study Low-Dose Transdermal Testosterone Therapy Improves Angina Threshold in Men With , 2000 .

[7]  L. Doncarlos,et al.  Differential expression of estrogen receptor alpha and beta in rat dorsal root ganglion neurons , 1999, Journal of neuroscience research.

[8]  M. Wilson,et al.  Sex differences in hippocampal slice excitability: role of testosterone , 2002, Neuroscience.

[9]  C. Bosco,et al.  Glucocorticoid receptors in human peripheral blood mononuclear cells in relation to explosive performance in elite handball players. , 2001, Life sciences.

[10]  J. H. Andersen,et al.  Association between plasma testosterone and work-related neck and shoulder disorders among female workers. , 2000, Scandinavian journal of work, environment & health.

[11]  O. Hermanson,et al.  Estrogen receptor-like immunoreactivity in the medullary and spinal dorsal horn of the female rat , 1995, Neuroscience Letters.

[12]  P. Salmon,et al.  Childhood trauma and diurnal cortisol disruption in fibromyalgia syndrome , 2006, Psychoneuroendocrinology.

[13]  A. Gintzler,et al.  Gestational and ovarian sex steroid antinociception: synergy between spinal κ and δ opioid systems , 1998, Brain Research.

[14]  Satoshi Minoshima,et al.  Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans , 1998, Pain.

[15]  A. Aloisi,et al.  The behavioral and neuronal effects induced by repetitive nociceptive stimulation are affected by gonadal hormones in male rats , 2003, Pain.

[16]  G. Chrousos,et al.  Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction. , 1993, The Journal of clinical investigation.

[17]  C. Elger,et al.  Neuroactive steroids and seizure susceptibility , 2001, Epilepsy Research.

[18]  S. Dworkin,et al.  Changes in temporomandibular pain and other symptoms across the menstrual cycle , 2003, Pain.

[19]  S. Lu,et al.  Neural androgen receptor regulation: effects of androgen and antiandrogen. , 1999, Journal of neurobiology.

[20]  E. Griep,et al.  Glucocorticoid receptors, fibromyalgia and low back pain , 1997, Psychoneuroendocrinology.

[21]  S. Segovia,et al.  Female's DHT controls sex differences in the rat bed nucleus of the accessory olfactory tract , 1992, Neuroreport.

[22]  A. Morales.  Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age [published erratum appears in J Clin Endocrinol Metab 1995 Sep;80(9):2799] , 1994 .

[23]  Meharvan Singh,et al.  Novel Mechanisms of Estrogen Action in the Brain: New Players in an Old Story , 1999, Frontiers in Neuroendocrinology.

[24]  D. Marcus.  Interrelationships of neurochemicals, estrogen, and recurring headache , 1995, Pain.

[25]  S. Lightman,et al.  A protective role for testosterone in adjuvant-induced arthritis. , 1995, British journal of rheumatology.

[26]  T. Teyler,et al.  Gonadal steroids: effects on excitability of hippocampal pyramidal cells. , 1980, Science.

[27]  A. Aloisi,et al.  Testosterone affects formalin-induced responses differently in male and female rats , 2004, Neuroscience Letters.

[28]  Marco Bonifazi,et al.  Effects of gonadal steroids on the input–output relationship of the corticospinal pathway in humans , 2004, Brain Research.

[29]  R. Hochberg,et al.  Regulation of estrogen receptor concentrations in the rat brain: effects of sustained androgen and estrogen exposure. , 1996, Neuroendocrinology.

[30]  C. Woolley,et al.  Hormonal Effects on the Brain , 1998, Epilepsia.

[31]  G. Adler,et al.  Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. , 1999, The American journal of medicine.

[32]  D. Pfaff,et al.  Estradiol Regulation of Estrogen Receptor Messenger Ribonucleic Acid in Rat Mediobasal Hypothalamus: An in situ Hybridization Study , 1990, Journal of neuroendocrinology.

[33]  Mitsuhiro Kawata,et al.  Roles of steroid hormones and their receptors in structural organization in the nervous system , 1995, Neuroscience Research.

[34]  N. Takata,et al.  Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction. , 2003, Biochimica et biophysica acta.

[35]  T. Dao,et al.  Gender differences in pain. , 1995, Journal of orofacial pain.

[36]  E. Simpson.  Sources of estrogen and their importance , 2003, The Journal of Steroid Biochemistry and Molecular Biology.

[37]  E. Lephart,et al.  A review of brain aromatase cytochrome P450 , 1996, Brain Research Reviews.

[38]  P. Shughrue,et al.  Sex-related differences in the distribution of opioid receptor-like 1 receptor mRNA and colocalization with estrogen receptor mRNA in neurons of the spinal trigeminal nucleus caudalis in the rat , 2003, Neuroscience.

[39]  F. Wolfe,et al.  Aspects of fibromyalgia in the general population: sex, pain threshold, and fibromyalgia symptoms. , 1995, The Journal of rheumatology.

[40]  S. Yen,et al.  Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. , 1994, The Journal of clinical endocrinology and metabolism.

[41]  E. Kajantie,et al.  The effects of sex and hormonal status on the physiological response to acute psychosocial stress , 2006, Psychoneuroendocrinology.

[42]  J. Morrell,et al.  Circulating gonadal steroid hormones regulate estrogen receptor mRNA in the male rat forebrain. , 1993, Brain research. Molecular brain research.

[43]  D. Hellhammer,et al.  Psychological and endocrine correlates of chronic pelvic pain associated with adhesions. , 1999, Journal of psychosomatic obstetrics and gynaecology.

[44]  W. Maixner,et al.  Cigarette smoking, stress-induced analgesia and pain perception in men and women , 2005, Pain.

[45]  A. Abdel‐Rahman,et al.  Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats. , 2000, European journal of endocrinology.

[46]  U. Anderberg,et al.  Pain Perception across the Menstrual Cycle Phases in Women with Chronic Pain , 2003, Perceptual and motor skills.

[47]  C. Flores,et al.  Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations , 2001, Neuroscience.

[48]  H. Zakon.  The effects of steroid hormones on electrical activity of excitable cells , 1998, Trends in Neurosciences.

[49]  N. MacLusky,et al.  Testosterone and its metabolites affect afterdischarge thresholds and the development of amygdala kindled seizures , 1999, Brain Research.

[50]  A. Aloisi,et al.  Role of gonadal hormones in formalin-induced pain responses of male rats: modulation by estradiol and naloxone administration , 1999, Neuroscience.

[51]  J. Bensing,et al.  Prevalence of chronic benign pain disorder among adults: a review of the literature , 1998, Pain.

[52]  S. Mellon.  Neurosteroids: biochemistry, modes of action, and clinical relevance. , 1994, The Journal of clinical endocrinology and metabolism.

[53]  Richard F. Thompson,et al.  17β-Estradiol Enhances NMDA Receptor-Mediated EPSPs and Long-Term Potentiation , 1999 .

[54]  F. Holsboer,et al.  Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology , 2001, Brain Research Reviews.

[55]  A. Aloisi,et al.  Gender-related effects of chronic non-malignant pain and opioid therapy on plasma levels of macrophage migration inhibitory factor (MIF) , 2005, Pain.

[56]  Leslie A. McClure,et al.  Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome , 2004, Brain, Behavior, and Immunity.

[57]  F. Holsboer,et al.  Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives , 1999, Trends in Neurosciences.

[58]  J. Gaughan,et al.  Expression of oestrogen receptor beta (ER beta) in multiple rat tissues visualised by immunohistochemistry. , 1997, The Journal of endocrinology.

[59]  A. Gintzler,et al.  Prolonged ovarian sex steroid treatment of male rats produces antinociception: identification of sex-based divergent analgesic mechanisms , 2000, Pain.

[60]  C. Woolley,et al.  Estradiol induces a phasic Fos response in the hippocampal CA1 and CA3 regions of adult female rats , 2000, Hippocampus.

[61]  B. Kudielka,et al.  Sex differences in HPA axis responses to stress: a review , 2005, Biological Psychology.

[62]  G. Taglialatela,et al.  Female Steroid Hormones Modulate Receptors for Nerve Growth Factor in Rat Dorsal Root Ganglia1 , 2001, Biology of reproduction.

[63]  D. Dorsa,et al.  Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: a comparison with ovariectomized females and intact males. , 1992, Endocrinology.

[64]  L. Doncarlos,et al.  Hormonal regulation of androgen receptor messenger RNA in the medial preoptic area of the male rat. , 1996, Brain research. Molecular brain research.

[65]  K. Berkley,et al.  Estrous Changes in Responses of Rat Gracile Nucleus Neurons to Stimulation of Skin and Pelvic Viscera , 2000, The Journal of Neuroscience.

[66]  P. Klein,et al.  Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism , 1998, Neurology.

[67]  D. Rubinow,et al.  Effects of ovarian hormones on human cortical excitability , 2002, Annals of neurology.

[68]  S. Silberstein,et al.  Hormone-related headache. , 2001, The Medical clinics of North America.

[69]  E. C. Dawson,et al.  Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome. , 2000, The Journal of rheumatology.

[70]  R. Sapolsky,et al.  How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. , 2000, Endocrine reviews.