Studies on new vasodilators, WS-1228 A and B. II. Structure and synthesis.

The structure of new hypotensive vasodilators, WS-1228 A and B, produced by Streptomyces aureofaciens, were determined as 1 and 2, respectively, on the basis of their spectral and chemical evidences.WS-1228 A (1), having N-hydroxytriazene moiety, was synthesized from (E, E, E)-2, 4, 7-undecatrienal (4) by condensation with hydrazine hydrate followed by nitrosation.