Spatial localization in the Morris water maze in rats: acquisition is affected by intra-accumbens injections of the dopaminergic antagonist haloperidol.

Previous studies (G. E. Ploeger, B. M. Spruijt, & A. R. Cools, 1992) showed that low doses of systemically injected haloperidol affected spatial learning in the Morris water maze. This study investigated effects of intra-accumbens injections of haloperidol on spatial learning. To control for motivation and sensorimotor coordination, the researchers trained the rats to escape onto a visible platform. Low doses (50-100 ng) of haloperidol impaired spatial learning, whereas escaping on a visible platform was undisturbed. The 500-ng dose of haloperidol completely blocked acquisition because of combined learning and motor impairments. Retrieval of an acquired escape response was unaffected by 500 ng haloperidol. The data show that mesolimbic dopaminergic activity is involved in the acquisition of spatial localization. The results are related to studies demonstrating the involvement of the nucleus accumbens in cue-directed behaviors.

[1]  Bryan Kolb,et al.  Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat , 1982, Neuroscience Letters.

[2]  A. D. Smith,et al.  Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat. , 1989, Journal of chemical neuroanatomy.

[3]  F. Fonnum,et al.  The effects of surgical and chemical lesions on neurotransmitter candidates in the nucleus accumbens of the rat , 1979, Neuroscience.

[4]  S. Yehuda,et al.  The use of the Morris Water Maze in the study of memory and learning. , 1989, The International journal of neuroscience.

[5]  A. Cools,et al.  Role of neostriatum and nucleus accumbens in stepping induced by apomorphine and dexamphetamine , 1991, Brain Research Bulletin.

[6]  T. Robbins,et al.  The effects of ibotenic acid lesions of the nucleus accumbens on spatial learning and extinction in the rat , 1989, Behavioural Brain Research.

[7]  Douglas L. Jones,et al.  From motivation to action: Functional interface between the limbic system and the motor system , 1980, Progress in Neurobiology.

[8]  S. Pr,et al.  Differential effects of microinjections of d-amphetamine into the nucleus accumbens or the caudate putamen on the rat's ability to ignore an irrelevant stimulus. , 1982 .

[9]  A. Imperato,et al.  Dopamine release in the nucleus caudatus and in the nucleus accumbens is under glutamatergic control through non-NMDA receptors: a study in freely-moving rats , 1990, Brain Research.

[10]  L. Nadel,et al.  The Hippocampus as a Cognitive Map , 1978 .

[11]  Joachim F. R. König,et al.  The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem , 1986 .

[12]  R. Beninger.  Dissociating the effects of altered dopaminergic function on performance and learning , 1989, Brain Research Bulletin.

[13]  S. Sesack,et al.  In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other , 1990, Brain Research.

[14]  A. Kelley,et al.  The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: An anterograde and retrograde-horseradish peroxidase study , 1982, Neuroscience.

[15]  A. Cools,et al.  The involvement of the nucleus accumbens in the ability of rats to switch to cue-directed behaviours. , 1989, Life sciences.

[16]  R. Morris,et al.  Place navigation impaired in rats with hippocampal lesions , 1982, Nature.

[17]  A. Cools,et al.  Evidence for a role of the caudate nucleus in the sequential organization of behaviour , 1982, Behavioural Brain Research.

[18]  A. Cools,et al.  Differential effects of striatal injections of dopaminergic, cholinergic and GABAergic drugs upon swimming behavior of rats , 1986, Brain Research.

[19]  G. Mogenson,et al.  An electrophysiological study of the neural projections from the hippocampus to the ventral pallidum and the subpallidal areas by way of the nucleus accumbens , 1985, Neuroscience.

[20]  A. Cools,et al.  Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in novelty-induced changes in hippocampal dynorphin B expression and two-way active avoidance: A new key in the search for the role of the hippocampal-accumbens axis , 1993, Behavioural Brain Research.

[21]  R. Bos.  The nucleus accumbens and subpallidal areas: a study on their role in behaviour in rats , 1991 .

[22]  R. Pagano.  Understanding Statistics in the Behavioral Sciences , 1981 .

[23]  R. Morris.  Spatial Localization Does Not Require the Presence of Local Cues , 1981 .

[24]  R. J. McDonald,et al.  Hippocampus, amygdala, and memory deficits in rats , 1990, Behavioural Brain Research.

[25]  G. Mogenson,et al.  Dopamine enhances terminal excitability of hippocampal-accumbens neurons via D2 receptor: role of dopamine in presynaptic inhibition , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[26]  T. J. Walsh,et al.  Hyperactivity following intradentate injection of colchicine: A role for dopamine systems in the nucleus accumbens , 1990, Pharmacology Biochemistry and Behavior.

[27]  J. Marchand,et al.  Convergence of excitatory amygdaloid and hippocampal input in the nucleus accumbens septi , 1980, Brain Research.

[28]  R. Sutherland,et al.  The role of the fornix/fimbria and some related subcortical structures in place learning and memory , 1989, Behavioural Brain Research.

[29]  A. Cools,et al.  Evidence that dopamine in the nucleus accumbens is involved in the ability of rats to switch to cue-directed behaviours , 1991, Behavioural Brain Research.

[30]  M. Witter,et al.  Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin , 1987, Neuroscience.

[31]  O. Phillipson,et al.  The topographic order of inputs to nucleus accumbens in the rat , 1985, Neuroscience.

[32]  G. Mogenson,et al.  Electrophysiological responses of neurones in the nucleus accumbens to hippocampal stimulation and the attenuation of the excitatory responses by the mesolimbic dopaminergic system , 1984, Brain Research.

[33]  J. Falk.  Physiology and Behavior. , 1973 .

[34]  R. Oades.  The role of noradrenaline in tuning and dopamine in switching between signals in the CNS , 1985, Neuroscience & Biobehavioral Reviews.

[35]  I. Divac,et al.  Current Conceptions of Neostriatal Functions History and an Evaluation , 1979 .

[36]  R. Morris,et al.  Allocentric Spatial Learning by Hippocampectomised Rats: A Further Test of the “Spatial Mapping” and “Working Memory” Theories of Hippocampal Function , 1986, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[37]  Berry M. Spruijt,et al.  Approach, avoidance, and contact behavior of individually recognized animals automatically quantified with an imaging technique , 1992, Physiology & Behavior.

[38]  T. van Groen,et al.  Extrinsic projections from area CA1 of the rat hippocampus: Olfactory, cortical, subcortical, and bilateral hippocampal formation projections , 1990, The Journal of comparative neurology.

[39]  A. Cools,et al.  Effects of haloperidol on the acquisition of a spatial learning task , 1992, Physiology & Behavior.

[40]  R. Morris.  Developments of a water-maze procedure for studying spatial learning in the rat , 1984, Journal of Neuroscience Methods.

[41]  G. Mogenson,et al.  A study of the contribution of hippocampal-accumbens-subpallidal projections to locomotor activity. , 1984, Behavioral and neural biology.

[42]  R. Beninger.  The role of dopamine in locomotor activity and learning , 1983, Brain Research Reviews.