EEG Resonant Responses in Schizophrenia: a Photic Driving Study with Improved Harmonic Resolution

Twenty seven drug-free schizophrenic patients and 25 normal controls were studied in an EEG photic driving paradigm with an improved harmonic resolution. Consistent with previous results, the present data show that schizophrenics have lower EEG responses to photic stimulation in alpha frequency. The differences between normal and schizophrenic subjects were distributed across major brain areas except centro-temporal regions. It also demonstrated that 1-Hz narrow-pulsed stimulation was feasible in EEG photic driving studies. The enhanced harmonic resolution produced significantly more information in the frequency domain about EEG oscillatory responses to visual stimulus. Using this new technique, the authors showed for the first time that alpha photic driving was a well defined resonant system and that the group differences in harmonic responses were primarily confined in the high frequency portion of alpha band, suggesting a peak frequency shift of EEG resonance in schizophrenia.

[1]  The electroencephalogram in the prediction of human reaction time during growth and development , 1975, Biological Psychology.

[2]  D. Lindsley.  Psychological phenomena and the electroencephalogram. , 1952, Electroencephalography and clinical neurophysiology.

[3]  G. Kreezer.  Intelligence Level and Occipital Alpha Rhythm in the Mongolian Type of Mental Deficiency , 1939 .

[4]  C. Sandman,et al.  Clozapine increases EEG photic driving in clinical responders. , 1995, Schizophrenia bulletin.

[5]  R Isenhart,et al.  Abnormal EEG responses to photic stimulation in schizophrenic patients. , 1990, Schizophrenia bulletin.

[6]  W. E. RahmJr.,et al.  Aspects of the electroencephalogram in epilepsy and feeblemindedness , 1938 .

[7]  D. Regan.  Evoked Potentials in Psychology, Sensory Physiology and Clinical Medicine , 1972 .

[8]  D. Regan.  Human brain electrophysiology: Evoked potentials and evoked magnetic fields in science and medicine , 1989 .

[9]  D. Lindsley.  Electrical Potentials of the Brain in Children and Adults , 1938 .

[10]  W. Surwillo,et al.  The relation of simple response time to brain-wave frequency and the effects of age. , 1963, Electroencephalography and clinical neurophysiology.

[11]  W. Surwillo.  Human reaction time and period of the EEG in relation to development. , 1971, Psychophysiology.

[12]  C A Sandman,et al.  Topographic Analysis of EEG Photic Driving in Patients with Schizophrenia following Clozapine Treatment , 1998, Clinical EEG.

[13]  Lindsley Db.  Basic perceptual processes and the EEG. , 1956 .

[14]  W. Surwillo.  Period analysis of the EEG in relation to age and reaction time in children. , 1972, Psychophysiology.

[15]  J. Knott,et al.  Some electroencephalographic correlates of intelligence in eight-year- and twelve-year-old children , 1942 .

[16]  C A Sandman,et al.  Topographic Analysis of EEG Photic Driving in Normal and Schizophrenic Subjects , 1995, Clinical EEG.

[17]  A. Mundy-castle,et al.  Electrophysiological correlates of intelligence. , 1958, Journal of personality.

[18]  E. Basar.  EEG-brain dynamics: Relation between EEG and Brain evoked potentials , 1980 .

[19]  J Röschke,et al.  Sequential analysis of the brain's transfer properties during consecutive REM episodes. , 1995, Electroencephalography and clinical neurophysiology.

[20]  Y. Wada,et al.  Abnormal photic driving responses in never-medicated schizophrenia patients. , 1995, Schizophrenia bulletin.

[21]  R. Lansing,et al.  Relation of brain and tremor rhythms to visual reaction time. , 1957, Electroencephalography and clinical neurophysiology.

[22]  D. Woodruff.  Relationships among EEG alpha frequency, reaction time, and age: a biofeedback study. , 1975, Psychophysiology.

[23]  Steven G. Potkin,et al.  Electroencephalographic photic driving in patients with schizophrenia and depression , 1997, Biological Psychiatry.

[24]  W. Surwillo,et al.  THE RELATION OF DECISION TIME TO BRAIN WAVE FREQUENCY AND TO AGE. , 1964, Electroencephalography and clinical neurophysiology.