Direct evidence for calcium‐induced ischemic and reperfusion injury

Changes in cytosolic free calcium ([Ca2+]i) in the cat cortex were measured in vivo by indo‐1 fluorometry during cerebral ischemia and reperfusion and were correlated to the histopathological ischemic changes. These changes were most pronounced in stroke cases with an increase in [Ca2+]i throughout the ischemic and reperfusion periods. Cases without a [Ca2+]i increase showed no histopathological change in the cortical gyrus in which [Ca2+]i was measured. The data support the hypothesis that an increase in [Ca 2+]i during cerebral ischemia and reperfusion leads to neuronal damage.

[1]  M. Reivich,et al.  In vivo measurement of cytosolic free calcium during cerebral ischemia and reperfusion , 1988, Annals of neurology.

[2]  M. Reivich,et al.  Kinetics of microcirculatory, NAD/NADH, and electrocorticographic changes in cat brain cortex during ischemia and recirculation , 1986, Annals of neurology.

[3]  B. Siesjö.  Calcium and ischemic brain damage. , 1986, European neurology.

[4]  T. Peters.  Calcium in physiological and pathological cell function. , 1986, European neurology.

[5]  Stephen J. Smith,et al.  NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones , 1986, Nature.

[6]  Kortaro Tanaka,et al.  Regional Flow-Metabolism Couple following Middle Cerebral Artery Occlusion in Cats , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  R. Tsien,et al.  A new generation of Ca2+ indicators with greatly improved fluorescence properties. , 1985, The Journal of biological chemistry.

[8]  K. Kogure,et al.  Free radical damage of the brain following ischemia. , 1985, Progress in brain research.

[9]  H. Benveniste,et al.  Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis , 1984, Journal of neurochemistry.

[10]  L. Symon,et al.  Extracellular pH, Potassium, and Calcium Activities in Progressive Ischaemia of Rat Cortex , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11]  M. Raichle.  The pathophysiology of brain ischemia , 1983, Annals of neurology.

[12]  L. Symon,et al.  Changes in Extracellular Calcium Activity in Cerebral Ischaemia , 1981, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[13]  B. Siesjö.  Cell Damage in the Brain: A Speculative Synthesis , 1981, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[14]  D. Graham,et al.  Diffuse cerebral ischemia in the cat: III. Neuropathological sequelae of severe ischemia , 1979, Annals of neurology.