Successful treatment of Pseudomonas cepacia endocarditis in a heroin addict with trimethoprim-sulfamethoxazole.

altered significantly the clinical forms and microorganisms producing infective endocarditis that are encountered in hospitals serving urban areas [1]. Although narcotic addiction has contributed primarily to the increased incidence of Staphylococcus aureus and candida endocarditis, unusual organisms are being seen with an increased frequency. We recently had two patients with endocarditis caused by Pseudomonas cepacia. One was successfully treated with trimethoprim (TMP), initially in combination with sulfadiazine and subsequently with sulfamethoxazole (SMZ).