Fulminant BCG Disease in a 7 Month Old Healthy Male Infant.

A seven month old healthy male infant was brought with papular skin lesions all over the body, which became ulcerative with increasing fever and redness within 1 week duration. On examination, Bacilli Calmette Guerin (BCG) scar was ulcerated with discharge; infant was irritable with tachycardia and tachypnea. Investigations revealed pancytopenia, and acid fast bacilli was positive in skin lesions and at BCG scar site. There was progressive worsening of infant's condition, culminating in death.

[1]  A. Aghamohammadi,et al.  Clinical, laboratory and imaging findings of the patients with disseminated bacilli Calmette-Guerin disease. , 2015, Allergologia et immunopathologia.

[2]  C. Indumathi,et al.  Clinical profile and outcome of clinical BCG disease in infants , 2014, Indian Pediatrics.

[3]  Jinqiao Sun,et al.  Clinical Characteristics and Immunogenetics of BCGosis/BCGitis in Chinese Children: A 6 Year Follow-Up Study , 2014, PloS one.

[4]  Behrman,et al.  Nelson text book of pediatrics , 2012 .

[5]  S. Rosenzweig,et al.  Bacillus Calmette-Guérin (BCG) complications associated with primary immunodeficiency diseases. , 2012, The Journal of infection.

[6]  E. Faria,et al.  Severe axillary lymphadenitis after BCG vaccination: alert for primary immunodeficiencies. , 2010, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[7]  J. Casanova,et al.  Bacille Calmette-Guérin infection and disease with fatal outcome associated with a point mutation in the interleukin-12/interleukin-23 receptor beta-1 chain in two Mexican families. , 2010, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[8]  C. Tzen,et al.  Disseminated Bacille Calmette-Guérin disease as the initial presentation of X-linked severe combined immunodeficiency--a case report. , 2005, Asian Pacific journal of allergy and immunology.

[9]  J. Casanova,et al.  Inherited disorders of the IL-12-IFN-γ axis in patients with disseminated BCG infection , 2005, European Journal of Pediatrics.

[10]  J. Casanova,et al.  Inherited disorders of the IL-12-IFN-gamma axis in patients with disseminated BCG infection. , 2005, European journal of pediatrics.

[11]  O. Sanal,et al.  Isolated cutaneous response to granulocyte-monocyte colony stimulating factor in fatal idiopathic disseminated Bacillus-Calmette-Guerin infection , 2000, European Journal of Pediatrics.

[12]  J. Grange Complications of bacille Calmette-Guérin (BCG) vaccination and immunotherapy and their management. , 1998, Communicable disease and public health.

[13]  I. N. Brown,et al.  Familial disseminated atypical mycobacterial infection in childhood: a human mycobacterial susceptibility gene? , 1995, The Lancet.