Essential role of mouse telomerase in highly proliferative organs

[1]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[2]  M. Bass,et al.  Human telomerase contains evolutionarily conserved catalytic and structural subunits. , 1997, Genes & development.

[3]  D. Bowtell,et al.  Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. , 1997, Human molecular genetics.

[4]  María A Blasco,et al.  Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA , 1997, Cell.

[5]  R. Weinberg,et al.  hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization , 1997, Cell.

[6]  C B Harley,et al.  Telomerase catalytic subunit homologs from fission yeast and human. , 1997, Science.

[7]  H. Tanke,et al.  Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[8]  T R Hughes,et al.  Reverse transcriptase motifs in the catalytic subunit of telomerase. , 1997, Science.

[9]  R. Effros,et al.  Mechanism of telomerase induction during T cell activation. , 1996, Experimental cell research.

[10]  C. Greider,et al.  Telomerase regulation during entry into the cell cycle in normal human T cells. , 1996, Molecular biology of the cell.

[11]  E. Blackburn,et al.  Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. , 1996, Genes & development.

[12]  B. Levine,et al.  Regulated expression of telomerase activity in human T lymphocyte development and activation , 1996, The Journal of experimental medicine.

[13]  et al.,et al.  The RNA component of human telomerase , 1995, Science.

[14]  E. Blackburn,et al.  Runaway telomere elongation caused by telomerase RNA gene mutations , 1995, Nature.

[15]  C. Greider,et al.  Developmental and tissue-specific regulation of mouse telomerase and telomere length. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[16]  C B Harley,et al.  Specific association of human telomerase activity with immortal cells and cancer. , 1994, Science.

[17]  D. Gottschling,et al.  TLC1: template RNA component of Saccharomyces cerevisiae telomerase. , 1994, Science.

[18]  R. DePinho,et al.  p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens , 1994, Nature.

[19]  Virginia A. Zakian,et al.  Loss of a yeast telomere: Arrest, recovery, and chromosome loss , 1993, Cell.

[20]  S. Watt,et al.  Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells , 1992, Cell proliferation.

[21]  J. Steitz,et al.  Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. , 1992, The EMBO journal.

[22]  C. Greider.  Chromosome first aid , 1991, Cell.

[23]  G. Cunha,et al.  Postnatal Growth of Mouse Seminal Vesicle Is Dependent on 5α-Dihydrotestosterone* , 1990 .

[24]  D. Kipling,et al.  Hypervariable ultra-long telomeres in mice , 1990, Nature.

[25]  Robin C. Allshire,et al.  Telomere reduction in human colorectal carcinoma and with ageing , 1990, Nature.

[26]  C. Harley,et al.  Telomeres shorten during ageing of human fibroblasts , 1990, Nature.

[27]  E. Blackburn,et al.  A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis , 1989, Nature.

[28]  Carol W. Greider,et al.  Identification of a specific telomere terminal transferase activity in tetrahymena extracts , 1985, Cell.

[29]  J. Haber,et al.  Healing of broken linear dicentric chromosomes in yeast. , 1984, Genetics.

[30]  I. Christensen,et al.  A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. , 1983, Cytometry.

[31]  B. Mcclintock,et al.  The Stability of Broken Ends of Chromosomes in Zea Mays. , 1941, Genetics.

[32]  S. Wright,et al.  Systems of Mating. I. the Biometric Relations between Parent and Offspring. , 1921, Genetics.

[33]  F. Ishikawa,et al.  Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas , 1998, Nature Genetics.

[34]  C. Greider.  Telomere length regulation. , 1996, Annual review of biochemistry.

[35]  J. Drost,et al.  Biological basis of germline mutation: Comparisons of spontaneous germline mutation rates among drosophila, mouse, and human , 1995, Environmental and molecular mutagenesis.