The temporal relationship between speech auditory brainstem responses and the acoustic pattern of the phoneme /ba/ in normal-hearing adults

OBJECTIVE To investigate the temporal relationship between speech auditory brainstem responses and acoustic pattern of the phoneme /ba/. METHODS Speech elicited auditory brainstem responses (Speech ABR) to /ba/ were recorded in 23 normal-hearing subjects. Effect of stimulus intensity was assessed on Speech ABR components latencies in 11 subjects. The effect of different transducers on electromagnetic leakage was also measured. RESULTS Speech ABR showed a reproducible onset response (OR) 6ms after stimulus onset. The frequency following response (FFR) waveform mimicked the 500Hz low pass filtered temporal waveform of phoneme /ba/ with a latency shift of 14.6ms. In addition, the OR and FFR latencies decreased with increasing stimulus intensity, with a greater rate for FFR (-1.4ms/10dB) than for OR (-0.6ms/10dB). CONCLUSIONS A close relationship was found between the pattern of the acoustic stimulus and the FFR temporal structure. Furthermore, differences in latency behaviour suggest different generation mechanisms for FFR and OR. SIGNIFICANCE The results provided further insight into the temporal encoding of basic speech stimulus at the brainstem level in humans.

[1]  Nina Kraus,et al.  Brainstem origins for cortical ‘what’ and ‘where’ pathways in the auditory system , 2005, Trends in Neurosciences.

[2]  N. Kraus,et al.  On the Relationship between Speech- and Nonspeech-Evoked Auditory Brainstem Responses , 2006, Audiology and Neurotology.

[3]  J. Hall.  Auditory brainstem frequency following responses to waveform envelope periodicity. , 1979, Science.

[4]  G Moushegian,et al.  Laboratory note. Scalp-recorded early responses in man to frequencies in the speech range. , 1973, Electroencephalography and clinical neurophysiology.

[5]  Nina Kraus,et al.  Brainstem responses to speech syllables , 2004, Clinical Neurophysiology.

[6]  H Pratt,et al.  Sources of frequency following responses (FFR) in man. , 1977, Electroencephalography and clinical neurophysiology.

[7]  M. Sams,et al.  Musicians have enhanced subcortical auditory and audiovisual processing of speech and music , 2007, Proceedings of the National Academy of Sciences.

[8]  B. Kollmeier,et al.  A neural circuit transforming temporal periodicity information into a rate-based representation in the mammalian auditory system. , 2007, The Journal of the Acoustical Society of America.

[9]  Brainstem Frequency-following Response Recorded from One Vertical and Three Horizontal Electrode Derivations , 2001, Perceptual and motor skills.

[10]  R. Dobie,et al.  Electrophysiologic Assessment of Low-Frequency Hearing: Sedation Effects , 1989, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[11]  G. Moushegian,et al.  The frequency-following response in subjects with profound unilateral hearing loss. , 1976, Electroencephalography and clinical neurophysiology.

[12]  R V Shannon,et al.  Speech Recognition with Primarily Temporal Cues , 1995, Science.

[13]  D L Jewett,et al.  Human Auditory Evoked Potentials: Possible Brain Stem Components Detected on the Scalp , 1970, Science.

[14]  T. Sejnowski,et al.  23 problems in systems neuroscience , 2006 .

[15]  Terence W Picton,et al.  Human temporal auditory acuity as assessed by envelope following responses. , 2004, The Journal of the Acoustical Society of America.

[16]  Yisheng Xu,et al.  Human frequency-following response: representation of pitch contours in Chinese tones , 2004, Hearing Research.

[17]  J. D. Weerd,et al.  Evoked Potential Manual , 1990, Springer Netherlands.

[18]  Christian Lorenzi,et al.  The ability of listeners to use recovered envelope cues from speech fine structure. , 2006, The Journal of the Acoustical Society of America.

[19]  C. E. Carr,et al.  Are Neurons Adapted for Specific Computations? Examples from Temporal Coding in the Auditory System , 2005 .

[20]  A M Liberman,et al.  Perception of the speech code. , 1967, Psychological review.

[21]  W. S. Rhode,et al.  Encoding of amplitude modulation in the cochlear nucleus of the cat. , 1994, Journal of neurophysiology.

[22]  Bharath Chandrasekaran,et al.  Experience-dependent neural plasticity is sensitive to shape of pitch contours , 2007, Neuroreport.

[23]  Torsten Dau,et al.  Influence of cochlear traveling wave and neural adaptation on auditory brainstem responses , 2005, Hearing Research.

[24]  J. Eggermont.  Between sound and perception: reviewing the search for a neural code , 2001, Hearing Research.

[25]  T. Picton,et al.  Human auditory steady-state responses to amplitude-modulated tones: phase and latency measurements , 2000, Hearing Research.

[26]  Terence W. Picton,et al.  Envelope Following Responses to Natural Vowels , 2006, Audiology and Neurotology.

[27]  Nina Kraus,et al.  Effects of noise and cue enhancement on neural responses to speech in auditory midbrain, thalamus and cortex , 2002, Hearing Research.

[28]  P. Cariani,et al.  Encoding of pitch in the human brainstem is sensitive to language experience. , 2005, Brain research. Cognitive brain research.

[29]  J. Eggermont,et al.  The auditory brainstem response , 1990 .

[30]  N. Viemeister.  Temporal modulation transfer functions based upon modulation thresholds. , 1979, The Journal of the Acoustical Society of America.

[31]  Bertrand Delgutte,et al.  Mathematical Models of Cochlear Nucleus Onset Neurons: II. Model with Dynamic Spike-Blocking State , 2004, Journal of Computational Neuroscience.

[32]  J C Smith,et al.  Auditory Frequency-Following Response: Neural or Artifact? , 1970, Science.

[33]  J. E. Rose,et al.  Phase-locked response to low-frequency tones in single auditory nerve fibers of the squirrel monkey. , 1967, Journal of neurophysiology.

[34]  Nina Kraus,et al.  Atypical brainstem representation of onset and formant structure of speech sounds in children with language-based learning problems , 2004, Biological Psychology.

[35]  Nicole M. Russo,et al.  Musical experience shapes human brainstem encoding of linguistic pitch patterns , 2007, Nature Neuroscience.

[36]  J. Ko.  Sensory discrimination: neural processes preceding discrimination decision. , 1980 .

[37]  G. Moushegian,et al.  Response characteristics of cochlear nucleus neurons to 500-Hz tones and noise: findings relating to frequency-following potentials. , 1982, Journal of neurophysiology.

[38]  K. O. Johnson,et al.  Sensory discrimination: neural processes preceding discrimination decision. , 1980, Journal of neurophysiology.

[39]  P. Joris,et al.  Detection of synchrony in the activity of auditory nerve fibers by octopus cells of the mammalian cochlear nucleus. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[40]  S. Hillyard,et al.  Human auditory evoked potentials. I. Evaluation of components. , 1974, Electroencephalography and clinical neurophysiology.

[41]  Steven Greenberg,et al.  Neural temporal coding of low pitch. I. Human frequency-following responses to complex tones , 1987, Hearing Research.

[42]  George Moushegian,et al.  Laboratory noteScalp-recorded early responses in man to frequencies in the speech rangeReponses precoces enregistrees sur le scalp chez l'homme a des frequences dans la gamme du langage , 1973 .

[43]  Nina Kraus,et al.  Brain Stem Response to Speech: A Biological Marker of Auditory Processing , 2005, Ear and hearing.

[44]  Fan-Gang Zeng,et al.  Speech recognition with amplitude and frequency modulations. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. T. Marsh,et al.  Far-field recorded frequency-following responses: evidence for the locus of brainstem sources. , 1975, Electroencephalography and clinical neurophysiology.

[46]  Perinatal Maturation of the Auditory Brain Stem Response: Changes in Path Length and Conduction Velocity , 1996, Ear and hearing.

[47]  E. Owens,et al.  An Introduction to the Psychology of Hearing , 1997 .

[48]  R. Burkard.  Human Auditory Evoked Potentials , 2010 .

[49]  Ananthanarayan Krishnan,et al.  Human frequency-following responses: representation of steady-state synthetic vowels , 2002, Hearing Research.

[50]  Brian C. J. Moore,et al.  Perception of Pitch by People with Cochlear Hearing Loss and by Cochlear Implant Users , 2005 .

[51]  Richard S. J. Frackowiak,et al.  Representation of the temporal envelope of sounds in the human brain. , 2000, Journal of neurophysiology.

[52]  G C Galbraith,et al.  Intelligible speech encoded in the human brain stem frequency-following response. , 1995, Neuroreport.

[53]  G M Clark,et al.  Temporal coding of frequency: neuron firing probabilities for acoustic and electric stimulation of the auditory nerve. , 1995, The Annals of otology, rhinology & laryngology. Supplement.

[54]  M. Semple,et al.  Auditory temporal processing: responses to sinusoidally amplitude-modulated tones in the inferior colliculus. , 2000, Journal of neurophysiology.

[55]  D. Caspary,et al.  Frequency-following responses in primary auditory and reticular formation structures. , 1979, Electroencephalography and clinical neurophysiology.

[56]  Frédéric Berthommier,et al.  Neuronal correlates of perceptual amplitude-modulation detection , 1995, Hearing Research.

[57]  B. Moore.  An introduction to the psychology of hearing, 3rd ed. , 1989 .

[58]  Jos J Eggermont,et al.  Effects of an acute acoustic trauma on the representation of a voice onset time continuum in cat primary auditory cortex , 2004, Hearing Research.