Structure, function and pharmacology of human itch GPCRs

[1]  Judy H. Cho,et al.  Inflamed ulcerative colitis regions associated to MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target. , 2021, Gastroenterology.

[2]  Saptarshi Roy,et al.  Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases , 2021, Current Allergy and Asthma Reports.

[3]  D. E. Nichols,et al.  Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor , 2020, Cell.

[4]  J Gomez-Blanco,et al.  DeepEMhancer: a deep learning solution for cryo-EM volume post-processing , 2020, Communications Biology.

[5]  John D. McCorvy,et al.  “TRUPATH, an Open-Source Biosensor Platform for Interrogating the GPCR Transducerome” , 2020, Nature Chemical Biology.

[6]  Reid H. J. Olsen,et al.  Nanobody-enabled monitoring of kappa opioid receptor states , 2020, Nature Communications.

[7]  David J. Fleet,et al.  Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction , 2019, Nature Methods.

[8]  Tristan Bepler,et al.  Topaz-Denoise: general deep denoising models for cryoEM and cryoET , 2019, Nature Communications.

[9]  M. Furuno,et al.  Novel MRGPRX2 antagonists inhibit IgE‐independent activation of human umbilical cord blood‐derived mast cells , 2019, Journal of leukocyte biology.

[10]  Saptarshi Roy,et al.  Identification of Gain and Loss of Function Missense Variants in MRGPRX2’s Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P , 2019, International journal of molecular sciences.

[11]  Xiaoqun Wang,et al.  MRGPRX4 is a bile acid receptor for human cholestatic itch , 2019, eLife.

[12]  Michael J. Robertson,et al.  GemSpot: A Pipeline for Robust Modeling of Ligands into CryoEM Maps , 2019, bioRxiv.

[13]  Reid H. J. Olsen,et al.  VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells , 2019, Cell.

[14]  S. Snyder,et al.  MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus , 2019, Proceedings of the National Academy of Sciences.

[15]  Xinzhong Dong,et al.  A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain , 2019, Neuron.

[16]  B. Roth,et al.  An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking , 2019, PLoS genetics.

[17]  S. Snyder,et al.  Identification of a bilirubin receptor that may mediate a component of cholestatic itch , 2019, eLife.

[18]  Naomi R. Latorraca,et al.  Structure of the µ-opioid receptor–Gi protein complex , 2018, Nature.

[19]  W. Baumeister,et al.  Structure of the adenosine-bound human adenosine A1 receptor–Gi complex , 2018, Nature.

[20]  Ryan T. Strachan,et al.  Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor , 2018, Cell.

[21]  Alexis Rohou,et al.  cisTEM: User-friendly software for single-particle image processing , 2017, bioRxiv.

[22]  Lei Lu,et al.  Peptide‐mediated mast cell activation: ligand similarities for receptor recognition and protease‐induced regulation , 2017, Journal of leukocyte biology.

[23]  E. Lerner,et al.  MRGPRX2, atopic dermatitis, and red man syndrome , 2017, Itch (Philadelphia, Pa.).

[24]  Anna L. Blobaum,et al.  Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain , 2017, Proceedings of the National Academy of Sciences.

[25]  David J. Fleet,et al.  cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination , 2017, Nature Methods.

[26]  Jing Liu,et al.  In silico design of novel probes for the atypical opioid receptor MRGPRX2 , 2016, Nature chemical biology.

[27]  R. M. Anthony,et al.  Dual action of neurokinin-1 antagonists on Mas-related GPCRs. , 2016, JCI insight.

[28]  Maria F. Sassano,et al.  PRESTO-TANGO: an open-source resource for interrogation of the druggable human GPCR-ome , 2015, Nature Structural &Molecular Biology.

[29]  Xinzhong Dong,et al.  Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions , 2014, Nature.

[30]  R. Stevens,et al.  Structural Features for Functional Selectivity at Serotonin Receptors , 2013, Science.

[31]  H. Subramanian,et al.  β-Defensins Activate Human Mast Cells via Mas-Related Gene X2 , 2013, The Journal of Immunology.

[32]  Maria F. Sassano,et al.  Automated design of ligands to polypharmacological profiles , 2012, Nature.

[33]  Randy J. Read,et al.  Acta Crystallographica Section D Biological , 2003 .

[34]  David J. Anderson,et al.  Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus , 2009, Cell.

[35]  Vincent B. Chen,et al.  Correspondence e-mail: , 2000 .

[36]  R. Stevens,et al.  GPCR Engineering Yields High-Resolution Structural Insights into β2-Adrenergic Receptor Function , 2007, Science.

[37]  M. Steinhoff,et al.  The neurobiology of itch , 2006, Nature Reviews Neuroscience.

[38]  David N Mastronarde,et al.  Automated electron microscope tomography using robust prediction of specimen movements. , 2005, Journal of structural biology.

[39]  Kevin Cowtan,et al.  research papers Acta Crystallographica Section D Biological , 2005 .

[40]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[41]  R. Henderson,et al.  Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy. , 2003, Journal of molecular biology.

[42]  David J. Anderson,et al.  Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  D. Banville,et al.  Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs , 2002, Nature Neuroscience.

[44]  K. Dan,et al.  N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents. 2. , 1989, Journal of medicinal chemistry.

[45]  X. Xie,et al.  Cryo-EM Structure of the Human Cannabinoid Receptor CB2-G i Signaling Complex , 2020 .

[46]  Min-Sung Kim,et al.  Transient mammalian cell transfection with polyethylenimine (PEI). , 2013, Methods in enzymology.

[47]  J Bernard Heymann,et al.  Bsoft: image processing and molecular modeling for electron microscopy. , 2007, Journal of structural biology.

[48]  Brian K. Shoichet,et al.  ZINC - A Free Database of Commercially Available Compounds for Virtual Screening , 2005, J. Chem. Inf. Model..