Characterization of Novel Murine and Human PDAC Cell Models: Identifying the Role of Intestine Specific Homeobox Gene ISX in Hypoxia and Disease Progression1

[1]  N. LaRusso,et al.  MicroRNA (miR)‐433 and miR‐22 dysregulations induce histone‐deacetylase‐6 overexpression and ciliary loss in cholangiocarcinoma , 2018, Hepatology.

[2]  A. Levine,et al.  Transcription factor ISX mediates the cross talk between diet and immunity , 2017, Proceedings of the National Academy of Sciences.

[3]  Chad J. Creighton,et al.  UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses , 2017, Neoplasia.

[4]  N. LaRusso,et al.  Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma. , 2017, Current drug targets.

[5]  Steven Gallinger,et al.  Molecular Events in the Natural History of Pancreatic Cancer. , 2017, Trends in cancer.

[6]  Hanlee P. Ji,et al.  Genomic Instability in Cancer: Teetering on the Limit of Tolerance. , 2017, Cancer research.

[7]  Tetsuo Kobayashi,et al.  Loss of a primary cilium in PDAC , 2017, Cell cycle.

[8]  C. Iacobuzio-Donahue,et al.  Pancreatic cancer biology and genetics from an evolutionary perspective , 2016, Nature Reviews Cancer.

[9]  C. Chai,et al.  Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC , 2016, Oncotarget.

[10]  J. Kleeff,et al.  The role of hypoxia in pancreatic cancer: a potential therapeutic target? , 2016, Expert review of gastroenterology & hepatology.

[11]  Kousuke Kasahara,et al.  Current topics of functional links between primary cilia and cell cycle , 2015, Cilia.

[12]  D. Tuveson,et al.  Preclinical models of pancreatic ductal adenocarcinoma , 2015, The Journal of pathology.

[13]  M. Reni,et al.  Metastatic pancreatic cancer: Is there a light at the end of the tunnel? , 2015, World journal of gastroenterology.

[14]  C. Giachino,et al.  Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions , 2015, Nucleic acids research.

[15]  H. Aburatani,et al.  ROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: Study in African‐American and Caucasian prostate cancer models , 2014, International journal of cancer.

[16]  D. Zurakowski,et al.  Urinary TIMP-1 and MMP-2 levels detect the presence of pancreatic malignancies , 2014, British Journal of Cancer.

[17]  A. Durczyński,et al.  Pancreatic head carcinoma and vascular endothelial growth factor (VEGF-A) concentration in portal blood: its association with cancer grade, tumor size and probably poor prognosis , 2014, Archives of medical science : AMS.

[18]  V. Adhami,et al.  The S100A4 Oncoprotein Promotes Prostate Tumorigenesis in a Transgenic Mouse Model: Regulating NFκB through the RAGE Receptor. , 2013, Genes & cancer.

[19]  N. LaRusso,et al.  HDAC6 inhibition restores ciliary expression and decreases tumor growth. , 2013, Cancer research.

[20]  C. Chai,et al.  Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma. , 2013, Cancer research.

[21]  A. Carrera,et al.  Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis , 2012, Molecular biology of the cell.

[22]  K. Labuzek,et al.  Concentrations and activities of metalloproteinases 2 and 9 and their inhibitors (TIMPS) in chronic pancreatitis and pancreatic adenocarcinoma. , 2012, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[23]  A. Baschnagel,et al.  Survival after chemoradiation in resected pancreatic cancer: the impact of adjuvant gemcitabine. , 2012, International journal of radiation oncology, biology, physics.

[24]  M. Hung,et al.  KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.

[25]  C. Poüs,et al.  The ins and outs of tubulin acetylation: more than just a post-translational modification? , 2011, Cellular signalling.

[26]  S. Shaw,et al.  Amphiastral Mitotic Spindle Assembly in Vertebrate Cells Lacking Centrosomes , 2011, Current Biology.

[27]  R. Tomasini,et al.  Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness , 2010, Cancers.

[28]  Andrew Menzies,et al.  The patterns and dynamics of genomic instability in metastatic pancreatic cancer , 2010, Nature.

[29]  K. Palczewski,et al.  ISX is a retinoic acid‐sensitive gatekeeper that controls intestinal β,β‐carotene absorption and vitamin A production , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  William T. Silkworth,et al.  Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells , 2009, PloS one.

[31]  D. Cleveland,et al.  Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis , 2009, Nature Reviews Molecular Cell Biology.

[32]  David Pellman,et al.  A Mechanism Linking Extra Centrosomes to Chromosomal Instability , 2009, Nature.

[33]  V. Adhami,et al.  Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling. , 2009, Carcinogenesis.

[34]  M. Lampson,et al.  Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates , 2009, Science.

[35]  G. Feldmann,et al.  Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice , 2008, Proceedings of the National Academy of Sciences.

[36]  C. Dervenis,et al.  Molecular aspects of carcinogenesis in pancreatic cancer. , 2008, Hepatobiliary & pancreatic diseases international : HBPD INT.

[37]  Duane A. Compton,et al.  Examining the link between chromosomal instability and aneuploidy in human cells , 2008, The Journal of cell biology.

[38]  A. Griffioen,et al.  NF-κB: a new player in angiostatic therapy , 2008, Angiogenesis.

[39]  E. Jaffee,et al.  Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations , 2007, Cytogenetic and Genome Research.

[40]  W. Weichert,et al.  High expression of RelA/p65 is associated with activation of nuclear factor-κB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis , 2007, British Journal of Cancer.

[41]  Michael Hu,et al.  A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development , 2006, Development.

[42]  Ralph Weissleder,et al.  Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[43]  J. Mesirov,et al.  From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005 .

[44]  R. DePinho,et al.  Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. , 2005, Cancer cell.

[45]  R. DePinho,et al.  Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. , 2003, Genes & development.

[46]  E. Petricoin,et al.  Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.

[47]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[48]  Douglas B. Evans,et al.  Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer? , 2001, International journal of radiation oncology, biology, physics.

[49]  A D Baxevanis,et al.  Molecular evolution of the homeodomain family of transcription factors. , 2001, Nucleic acids research.

[50]  E. Hinchcliffe,et al.  "It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle. , 2001, Genes & development.

[51]  H. Friess,et al.  Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[52]  N. Berbari,et al.  Methods for Visualization of Neuronal Cilia. , 2016, Methods in molecular biology.

[53]  E. Hinchcliffe.  Centrosomes and the art of mitotic spindle maintenance. , 2014, International review of cell and molecular biology.

[54]  H. Ford,et al.  The six family of homeobox genes in development and cancer. , 2008, Advances in cancer research.

[55]  T. Barrette,et al.  ONCOMINE: a cancer microarray database and integrated data-mining platform. , 2004, Neoplasia.

[56]  B. Brinkley,et al.  Managing the centrosome numbers game: from chaos to stability in cancer cell division. , 2001, Trends in cell biology.