Skin immune surveillance by T cells--a new order?

[1]  R. Clark,et al.  The Vast Majority of CLA+ T Cells Are Resident in Normal Skin1 , 2006, The Journal of Immunology.

[2]  A. Hayday,et al.  Anti‐inflammatory effects in the skin of thymosin‐β4 splice‐variants , 2003 .

[3]  A. McKenzie,et al.  IL-13 Is Necessary, Not Simply Sufficient, for Epicutaneously Induced Th2 Responses to Soluble Protein Antigen1 , 2003, The Journal of Immunology.

[4]  R. Clark,et al.  A novel method for the isolation of skin resident T cells from normal and diseased human skin. , 2006, The Journal of investigative dermatology.

[5]  N. Stanietsky,et al.  Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D , 2008, Nature Immunology.

[6]  Ozge Canli,et al.  gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. , 2009, Cancer cell.

[7]  J. Adams,et al.  Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response , 2006, Science.

[8]  G. Imokawa,et al.  Percutaneous sensitization with allergens through barrier‐disrupted skin elicits a Th2‐dominant cytokine response , 1998, European journal of immunology.

[9]  J. McGrath,et al.  Recent advances in the molecular basis of inherited skin diseases. , 2001, Advances in genetics.

[10]  R. Trembath,et al.  Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus. , 2002, American journal of human genetics.

[11]  J. Becker,et al.  Expression of stress-induced MHC class I related chain molecules on human melanoma. , 2002, The Journal of investigative dermatology.

[12]  J. Allison,et al.  Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells , 1989, Nature.

[13]  Julia M. Lewis,et al.  Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant , 2006, Nature Immunology.

[14]  A. Elbe-Bürger,et al.  Ontogeny of Langerin/CD207 expression in the epidermis of mice. , 2004, The Journal of investigative dermatology.

[15]  K. P. Murphy,et al.  Janeway's immunobiology , 2007 .

[16]  F. Hodi,et al.  Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[17]  C. Yee,et al.  Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation , 2002, Nature.

[18]  G. Eberl,et al.  Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation , 2008, Proceedings of the National Academy of Sciences.

[19]  C. Griffiths,et al.  Natural killer and natural killer-T cells in psoriasis , 2002, Archives of Dermatological Research.

[20]  G. Imokawa,et al.  Altered permeability and disordered cutaneous immunoregulatory function in mice with acute barrier disruption. , 1997, The Journal of investigative dermatology.

[21]  W. Caspary,et al.  The TCR δ Repertoire in Normal Human Skin is Restricted and Distinct from the TCR δ Repertoire in the Peripheral Blood , 2001 .

[22]  S. Fisher,et al.  Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations , 2001, The Lancet.

[23]  J. Jameson,et al.  Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1 , 2005, Nature Immunology.

[24]  M. Shlomchik,et al.  Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. , 2005, Immunity.

[25]  K. Asadullah,et al.  Inhibition of Keratinocyte Apoptosis by IL-15: A New Parameter in the Pathogenesis of Psoriasis?1 , 2000, The Journal of Immunology.

[26]  Frank O. Nestle,et al.  Spontaneous Development of Psoriasis in a New Animal Model Shows an Essential Role for Resident T Cells and Tumor Necrosis Factor-α , 2004, The Journal of experimental medicine.

[27]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[28]  M. Kasahara,et al.  Two Novel NKG2D Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to NKG2D1 , 2008, The Journal of Immunology.

[29]  Julia M. Lewis,et al.  Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells , 2008, Nature Genetics.

[30]  J. Adams,et al.  IL-15 Links TLR2/1-Induced Macrophage Differentiation to the Vitamin D-Dependent Antimicrobial Pathway , 2008, The Journal of Immunology.

[31]  O. Boyman,et al.  Plasmacytoid predendritic cells initiate psoriasis through interferon-α production , 2005, The Journal of experimental medicine.

[32]  Wancai Yang,et al.  γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity , 2003, The Journal of experimental medicine.

[33]  S. Porcelli,et al.  Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells1 , 2000, The Journal of Immunology.

[34]  P. Elias,et al.  Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. , 1992, The Journal of clinical investigation.

[35]  D. Roop,et al.  Defects in the barrier , 1995, Science.

[36]  Clare L. Bennett,et al.  Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity , 2005, The Journal of cell biology.

[37]  A. Hayday,et al.  Suppression of airway inflammation by a natural acute infection of the intestinal epithelium , 2009, Mucosal Immunology.

[38]  R. Strieter,et al.  Keratinocyte interleukin-10 expression is upregulated in tape-stripped skin, poison ivy dermatitis, and Sezary syndrome, but not in psoriatic plaques. , 1994, Clinical immunology and immunopathology.

[39]  P. Elias,et al.  Structural and lipid biochemical correlates of the epidermal permeability barrier. , 1991, Advances in lipid research.

[40]  B. Nickoloff,et al.  Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. , 1994, Journal of the American Academy of Dermatology.

[41]  F. Huang,et al.  A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes , 2000, The Journal of experimental medicine.

[42]  A. Irvine,et al.  Filaggrin in atopic dermatitis. , 2008, The Journal of allergy and clinical immunology.

[43]  P. Perrin,et al.  Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. , 2005, Immunity.

[44]  K. Huse,et al.  Sarcoidosis is associated with a truncating splice site mutation in BTNL2 , 2005, Nature Genetics.

[45]  A. Hayday,et al.  Environmentally Responsive and Reversible Regulation of Epidermal Barrier Function by γδ T Cells , 2006 .

[46]  P. Elias,et al.  Barrier disruption stimulates interleukin-1 alpha expression and release from a pre-formed pool in murine epidermis. , 1996, The Journal of investigative dermatology.

[47]  Lisa M. Ebert,et al.  Homing and Function of Human Skin γδ T Cells and NK Cells: Relevance for Tumor Surveillance , 2006, The Journal of Immunology.

[48]  M. Kapsenberg,et al.  Interleukin-17 in inflammatory skin disorders , 2007, Current opinion in allergy and clinical immunology.

[49]  I. Kimber,et al.  Langerhans cell migration , 2000, Clinical and experimental dermatology.

[50]  Junliang Pan,et al.  DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 , 2007, Nature Immunology.

[51]  C. Harding.  The stratum corneum: structure and function in health and disease , 2004, Dermatologic therapy.

[52]  Julia M. Lewis,et al.  TCR γ δ+ dendritic epidermal T cells as constituents of skin-associated lymphoid tissue , 1990 .

[53]  A. Hayday,et al.  Intraepithelial lymphocytes: exploring the Third Way in immunology , 2001, Nature Immunology.

[54]  K. Kabashima,et al.  Epidermal chemokines and modulation by antihistamines, antibiotics and antifungals , 2008, Experimental dermatology.

[55]  Julia M. Lewis,et al.  Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis , 2008, Nature Immunology.

[56]  D. Raulet.  Roles of the NKG2D immunoreceptor and its ligands , 2003, Nature Reviews Immunology.

[57]  Li V. Yang,et al.  Amphiregulin, a TH2 Cytokine Enhancing Resistance to Nematodes , 2006, Science.

[58]  Shinichiro Sawa,et al.  Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. , 2008, Immunity.

[59]  C. Bodemer,et al.  Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome , 2000, Nature Genetics.

[60]  W. Havran,et al.  Modulation of epithelial cell growth by intraepithelial gamma delta T cells. , 1994, Science.

[61]  Julia M. Lewis,et al.  Regulation of Cutaneous Malignancy by γδ T Cells , 2001, Science.

[62]  J. Letterio,et al.  A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology:  The Skin of   Transforming Growth Factor β1 Null Mice Is Devoid of  Epidermal Langerhans Cells , 1996, The Journal of experimental medicine.

[63]  Y. Chien,et al.  Recognition of self antigens by skin-derived T cells with invariant gamma delta antigen receptors. , 1991, Science.

[64]  Donald Y M Leung,et al.  Amendment history : Erratum ( April 2004 ) New insights into atopic dermatitis , 2018 .

[65]  R. Callard,et al.  Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[66]  Ekaterina S Jordanova,et al.  High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer. , 2007, Cancer research.

[67]  A. Hayday,et al.  The integration of conventional and unconventional T cells that characterizes cell-mediated responses. , 2005, Advances in immunology.

[68]  Eric J. Brown,et al.  The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor , 2005, Nature.

[69]  L. Lanier,et al.  NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. , 2003, Tissue antigens.

[70]  C. Herrick,et al.  Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. , 2000, The Journal of clinical investigation.

[71]  Ruslan Medzhitov,et al.  Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis , 2004, Cell.

[72]  M. Shlomchik,et al.  Langerhans cells are not required for efficient skin graft rejection. , 2008, The Journal of investigative dermatology.

[73]  Z. Trajanoski,et al.  Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome , 2006, Science.

[74]  P. Stastny,et al.  Antibodies against MICA antigens and kidney-transplant rejection. , 2007, The New England journal of medicine.

[75]  M. Röcken,et al.  Immunopathogenesis and role of T cells in psoriasis. , 2007, Clinics in dermatology.

[76]  H. Lane,et al.  IL‐15 acts as a potent inducer of CD4+CD25hi cells expressing FOXP3 , 2008, European journal of immunology.

[77]  A. Hayday,et al.  CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets , 2009, Nature Immunology.

[78]  E. Fuchs,et al.  A Role for Skin γδ T Cells in Wound Repair , 2002, Science.

[79]  R. Tigelaar,et al.  Immunobiology of mouse dendritic epidermal T cells: a decade later, some answers, but still more questions. , 1995, The Journal of investigative dermatology.

[80]  T. Spies,et al.  Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB , 1999 .

[81]  T. Shiohara,et al.  Pathophysiology of fixed drug eruption: the role of skin-resident T cells , 2002, Current opinion in allergy and clinical immunology.

[82]  G. Núñez,et al.  Caspase‐1 inflammasomes in infection and inflammation , 2007, Journal of leukocyte biology.

[83]  D. Geraghty,et al.  A second lineage of mammalian major histocompatibility complex class I genes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[84]  N. Boiani,et al.  BTNL2, a Butyrophilin/B7-Like Molecule, Is a Negative Costimulatory Molecule Modulated in Intestinal Inflammation , 2007, The Journal of Immunology.

[85]  U. Rassner,et al.  Basis for abnormal desquamation and permeability barrier dysfunction in RXLI. , 2004, The Journal of investigative dermatology.

[86]  T. Ley,et al.  Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. , 2007, Immunity.

[87]  K. Hogquist,et al.  Identification of a novel population of Langerin+ dendritic cells , 2007, The Journal of experimental medicine.

[88]  M. Leippe,et al.  The human antimicrobial protein psoriasin acts by permeabilization of bacterial membranes. , 2009, Developmental and comparative immunology.

[89]  J. Rast,et al.  Genomic Insights into the Immune System of the Sea Urchin , 2006, Science.

[90]  K. Matsui,et al.  Lipoteichoic acid from Staphylococcus aureus induces Th2‐prone dermatitis in mice sensitized percutaneously with an allergen , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[91]  Gerd Ritter,et al.  Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[92]  E. Devilard,et al.  The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells , 2007, The Journal of experimental medicine.

[93]  A. Hayday,et al.  Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance , 2005, Nature Immunology.

[94]  C. Sutherland,et al.  Human Cytomegalovirus Glycoprotein UL16 Causes Intracellular Sequestration of NKG2D Ligands, Protecting Against Natural Killer Cell Cytotoxicity , 2003, The Journal of experimental medicine.

[95]  F. Ginhoux,et al.  Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state , 2007, The Journal of experimental medicine.

[96]  R. Strong,et al.  Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands , 2007, Nature.

[97]  R. Callard,et al.  Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response , 2004 .

[98]  S. Jameson,et al.  Langerin Expressing Cells Promote Skin Immune Responses under Defined Conditions1 , 2008, The Journal of Immunology.

[99]  G. Abecasis,et al.  Gene polymorphism in Netherton and common atopic disease , 2001, Nature Genetics.

[100]  Peter M. Elias,et al.  The skin barrier as an innate immune element , 2007, Seminars in Immunopathology.

[101]  C. Sitaru,et al.  Immunopathology and molecular diagnosis of autoimmune bullous diseases , 2007, Journal of cellular and molecular medicine.

[102]  I. Weissman,et al.  Langerhans cells renew in the skin throughout life under steady-state conditions , 2002, Nature Immunology.

[103]  Julia M. Lewis,et al.  Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation , 2002, The Journal of experimental medicine.

[104]  Li-Fang Wang,et al.  Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. , 1996, Journal of immunology.

[105]  P. Elias,et al.  "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. , 2008, The Journal of investigative dermatology.

[106]  G. Belz,et al.  Skin-Derived Dendritic Cells Can Mediate Deletional Tolerance of Class I-Restricted Self-Reactive T Cells1 , 2007, The Journal of Immunology.

[107]  M. Julius,et al.  A Unique Subset of Self-specific Intraintestinal T Cells Maintains Gut Integrity , 2002, The Journal of experimental medicine.