Patterns and Quality of Buprenorphine Opioid Agonist Treatment in a Large Medicaid Program

Objectives:Use of buprenorphine – an effective treatment for opioid use disorders (OUDs) – has increased rapidly in recent years and is often financed by Medicaid. We investigated predictors of buprenorphine treatment, patterns of care, and quality of care in a large state Medicaid program. Methods:Data from Pennsylvania Medicaid from 2007 to 2012 provided information regarding diagnoses, demographic characteristics, enrollment, and use of inpatient and outpatient services, and prescription drugs. We identified adult enrollees using buprenorphine, and examined prevalence of OUD diagnosis and patterns of use (duration and dose) and quality of care (physician visits, receipt of behavioral health counseling, urine drug screens, and other prescription drug use). We use a mixed logistic regression model to examine enrollee characteristics associated with buprenorphine use. Results:The share of enrollees with OUD filling prescriptions for buprenorphine increased from 2985 (9.8%) to 12,691 (25.2%) from 2007 to 2012. Between 26.2 and 32.0% of enrollees using buprenorphine had no diagnosis of OUD, depending on the year. Only 60.1% of enrollees with buprenorphine use received at least one urine drug screen, 41.0% had behavioral health counseling services, and 34.7 and 38.0% had other opioid and benzodiazepine claims, respectively, concomitant with buprenorphine use. Quality of care was lower among those with no OUD diagnosis recorded. The mean daily doses of buprenorphine decreased over time. We found wide variation in likelihood of buprenorphine use among those with OUD based upon age, sex, and race. Conclusions:Increases in buprenorphine treatment in a Medicaid population were observed across time; however, increases varied by age, sex, and rate, and the quality of care received seemed to be generally poor. The quality of the provision of buprenorphine treatment occurring in Medicaid populations should be further explored.

[1]  P. O'Connor,et al.  Clinical practice. Office-based treatment of opioid-dependent patients. , 2002, The New England journal of medicine.

[2]  J. Streltzer,et al.  An observational study of buprenorphine treatment of the prescription opioid dependent pain patient. , 2015, The American journal on addictions.

[3]  A. Gifford,et al.  Implementation of buprenorphine in the Veterans Health Administration: results of the first 3 years. , 2007, Drug and alcohol dependence.

[4]  R. Brooner,et al.  Prevalence of psychiatric and substance use disorders in opioid abusers in a community syringe exchange program. , 2004, Drug and alcohol dependence.

[5]  Jasmina Burdzovic Andreas,et al.  Illicit use of opioid substitution drugs: prevalence, user characteristics, and the association with non-fatal overdoses. , 2015, Drug and alcohol dependence.

[6]  R. Clark,et al.  Responses of state Medicaid programs to buprenorphine diversion: doing more harm than good? , 2013, JAMA internal medicine.

[7]  R. Clark,et al.  The evidence doesn't justify steps by state Medicaid programs to restrict opioid addiction treatment with buprenorphine. , 2011, Health affairs.

[8]  Carrie M. Farmer,et al.  Practice Guidance for Buprenorphine for the Treatment of Opioid Use Disorders: Results of an Expert Panel Process , 2015, Substance abuse.

[9]  P. K. Adelmann Mental and Substance Use Disorders Among Medicaid Recipients: Prevalence Estimates from Two National Surveys , 2003, Administration and Policy in Mental Health and Mental Health Services Research.

[10]  W. Ling,et al.  Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. , 2003, The New England journal of medicine.

[11]  B. Barton,et al.  The impact of prior authorization on buprenorphine dose, relapse rates, and cost for Massachusetts Medicaid beneficiaries with opioid dependence. , 2014, Health services research.

[12]  Alex H. S. Harris,et al.  Trends in Opioid Agonist Therapy in the Veterans Health Administration: Is Supply Keeping up with Demand? , 2013, The American journal of drug and alcohol abuse.

[13]  Alex H. S. Harris,et al.  Receipt of opioid agonist treatment in the Veterans Health Administration: facility and patient factors. , 2012, Drug and alcohol dependence.

[14]  Declan T. Barry,et al.  A randomized trial of cognitive behavioral therapy in primary care-based buprenorphine. , 2013, The American journal of medicine.

[15]  S. Sonne,et al.  Adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence: a 2-phase randomized controlled trial. , 2011, Archives of general psychiatry.

[16]  N. West,et al.  Trends in abuse and misuse of prescription opioids among older adults. , 2015, Drug and alcohol dependence.

[17]  Helen Brown,et al.  Applied Mixed Models in Medicine , 2000, Technometrics.

[18]  M. Pantalon,et al.  Counseling plus buprenorphine-naloxone maintenance therapy for opioid dependence. , 2006, The New England journal of medicine.

[19]  Lori J. Ducharme,et al.  State policy influence on the early diffusion of buprenorphine in community treatment programs , 2008, Substance abuse treatment, prevention, and policy.

[20]  J. Potter,et al.  Sublingual Buprenorphine for Chronic Pain: A Survey of Clinician Prescribing Practices , 2014, The Clinical journal of pain.

[21]  Thomas R Frieden,et al.  Medication-assisted therapies--tackling the opioid-overdose epidemic. , 2014, The New England journal of medicine.

[22]  R. Weisberg,et al.  Chronic Pain and DepressionAmong Primary Care Patients Treated with Buprenorphine , 2015, Journal of General Internal Medicine.

[23]  R. Clark,et al.  Factors associated with Medicaid patients' access to buprenorphine treatment. , 2011, Journal of substance abuse treatment.

[24]  R. Clark,et al.  Adherence to Buprenorphine Treatment Guidelines in a Medicaid Program , 2015, Substance abuse.

[25]  D. Cheng,et al.  Office-Based Management of Opioid Dependence with Buprenorphine: Clinical Practices and Barriers , 2008, Journal of General Internal Medicine.

[26]  R. Rosenblatt,et al.  Geographic and Specialty Distribution of US Physicians Trained to Treat Opioid Use Disorder , 2015, The Annals of Family Medicine.

[27]  A. Rosenblum,et al.  Abuse and diversion of buprenorphine sublingual tablets and film. , 2014, Journal of substance abuse treatment.

[28]  James J Manlandro Buprenorphine for Office-Based Treatment of Patients With Opioid Addiction , 2005, The Journal of the American Osteopathic Association.

[29]  M. Soyka Buprenorphine–naloxone buccal soluble film for the treatment of opioid dependence: current update , 2015, Expert opinion on drug delivery.

[30]  P. Barnett Comparison of costs and utilization among buprenorphine and methadone patients. , 2009, Addiction.

[31]  R P Mattick,et al.  Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. , 2008, The Cochrane database of systematic reviews.

[32]  Rosalie Liccardo Pacula,et al.  Supply of buprenorphine waivered physicians: the influence of state policies. , 2015, Journal of substance abuse treatment.

[33]  Carrie M. Farmer,et al.  The impact of buprenorphine on treatment of opioid dependence in a Medicaid population: recent service utilization trends in the use of buprenorphine and methadone. , 2012, Drug and alcohol dependence.

[34]  R. Brooner,et al.  Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. , 1997, Archives of general psychiatry.

[35]  P. O'Connor,et al.  Cost analysis of clinic and office-based treatment of opioid dependence: results with methadone and buprenorphine in clinically stable patients. , 2009, Drug and Alcohol Dependence.

[36]  E. Lavonas,et al.  Root causes, clinical effects, and outcomes of unintentional exposures to buprenorphine by young children. , 2013, The Journal of pediatrics.