Fabrication of a biodegradable drug delivery system with controlled release made of PLGA/5‐FU/hydroxyapatite

Purpose – Rapid prototyping (RP) technology has been widely applied in biomedical research. The purpose of this paper is to describe how a scaffold composite drug delivery system (DDS) was fabricated using a nano composite deposition system (NCDS).Design/methodology/approach – A biocompatible and biodegradable thermoplastic polymer (poly(DL‐lactide‐co‐glycolide acid)) was used as the matrix, and a mixture of anti‐cancer drug (5‐fluorouracil) and bio‐ceramic (hydroxyapatite – HA) was added to the polymer to form a bio‐composite material for the DDS. An in vitro drug release test showed that the release rate of the drug composite could be controlled by the amount of HA for 50 days.Findings – Faster release was observed for the DDS with higher weight percent of HA. The relationship between release rate and the amount of HA showed a bi‐linear manner, and bi‐linear drug release models were developed based on the experimental results.Originality/value – Cylindrical scaffolds were fabricated with polymer/drug/ad...

[1]  Rapid prototyping: an innovative technique for microfabrication of metallic parts , 1996, MHS'96 Proceedings of the Seventh International Symposium on Micro Machine and Human Science.

[2]  C. Rhodes,et al.  Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches. , 1998, Drug development and industrial pharmacy.

[3]  Cheng Sun,et al.  Micro-stereolithography of polymeric and ceramic microstructures , 1999 .

[4]  M. Cima,et al.  A controlled-release microchip , 1999, Nature.

[5]  Y Ikada,et al.  Long-term sustained release of ganciclovir from biodegradable scleral implant for the treatment of cytomegalovirus retinitis. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[6]  C K Chua,et al.  Fabrication of porous polymeric matrix drug delivery devices using the selective laser sintering technique , 2001, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[7]  Jocelyne Bloch,et al.  Nerve Growth Factor- and Neurotrophin-3-Releasing Guidance Channels Promote Regeneration of the Transected Rat Dorsal Root , 2001, Experimental Neurology.

[8]  Chee Kai Chua,et al.  Characterization of SLS parts for drug delivery devices , 2001 .

[9]  K. H. Low,et al.  Characterization of microfeatures in selective laser sintered drug delivery devices , 2002, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[10]  Chee Kai Chua,et al.  Dual Material Rapid Prototyping Techniques for the Development of Biomedical Devices. Part 2: Secondary Powder Deposition , 2002 .

[11]  Han Tong Loh,et al.  Fabrication of 3D chitosan–hydroxyapatite scaffolds using a robotic dispensing system , 2002 .

[12]  Patrick Aebischer,et al.  Glial cell line‐derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat , 2002, Journal of neuroscience research.

[13]  D. Hutmacher,et al.  Scaffold development using 3D printing with a starch-based polymer , 2002 .

[14]  Patrick Aebischer,et al.  GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap , 2002, The European journal of neuroscience.

[15]  A. Ahluwalia,et al.  Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. , 2003, Biomaterials.

[16]  Nicholas A Peppas,et al.  Microfabricated drug delivery devices. , 2005, International journal of pharmaceutics.

[17]  Colleen L Flanagan,et al.  Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. , 2005, Biomaterials.

[18]  Mauro Onori,et al.  Implantable Drug Delivery Systems - Design Process , 2006 .

[19]  Chee Kai Chua,et al.  Building Porous Biopolymeric Microstructures for Controlled Drug Delivery Devices Using Selective Laser Sintering , 2006 .

[20]  Jack G. Zhou,et al.  Nanohole Fabrication using FIB, EB and AFM for Biomedical Applications , 2006 .

[21]  R. Drew,et al.  Wettability and spreading kinetics of molten aluminum on copper-coated ceramics , 2006 .

[22]  Sung-hoon Ahn,et al.  Micro/Nano Fabrication Technique in Drug Delivery System(DDS) , 2006 .

[23]  F. Prinz,et al.  Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers , 2007, Biomedical microdevices.

[24]  Fritz B Prinz,et al.  Biodegradable micro-osmotic pump for long-term and controlled release of basic fibroblast growth factor. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[25]  Sung Geun Kim,et al.  Fabrication of Bio-Composite Drug Delivery System Using Rapid Prototyping Technology , 2007 .

[26]  S. Willerth,et al.  Approaches to neural tissue engineering using scaffolds for drug delivery. , 2007, Advanced drug delivery reviews.

[27]  Syed H. Masood,et al.  Application of fused deposition modelling in controlled drug delivery devices , 2007 .

[28]  C K Chua,et al.  Characterization of a poly-epsilon-caprolactone polymeric drug delivery device built by selective laser sintering. , 2007, Bio-medical materials and engineering.

[29]  Chee Kai Chua,et al.  Improved biocomposite development of poly(vinyl alcohol) and hydroxyapatite for tissue engineering scaffold fabrication using selective laser sintering , 2008, Journal of materials science. Materials in medicine.