Effects of reinnervation on denervated skeletal muscle by axons of motor, sensory, and sympathetic neurons.

ZALEWSKI, ANDREW A. Efects of reinnervation on denervated skeletal muscle by axons uf motor, sensory, and sympathtic neurons. Am, J, Physiol. 219(6): 1675-1679. 1970.-Although the effects of denervation on skeletal muscle are reversed after reinnervation by axons of any somatic motor neurons, reinnervation by dendrites of sensory neurons has always proved unsuccessful. In order to determine whether the trophic function of nerve on muscle was specific to motor neuron axons, the sternomastoid muscle of adult rats was studied from 1 to 5 months after denervation and after reinnervation by the following axons: its original motor nerve, the motor hypoglossal nerve, the central fibers of the sensory neurons of the vagal nodose ganglion, and the preganglionic cervical sympathetic nerve fibers. Functional reinnervation was accomplished only by the axons of the motor sternomastoid (original nerve) and hypoglossal nerves. Muscles reinnervated by axons of sensory or sympathetic neurons all resembled chronically denervated muscle. The results demonstrate that axons of only motor neurons can restore denervated muscle. It is concluded therefore that the trophic influence of nerve on muscle is a property of axons of motor neurons and not of axons of sensory or sympathetic neurons.

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