Proteasome targeting by ubiquitin-like domains

Thank you for submitting your manuscript on proteasome targeting by ubiquitin-like domains to The EMBO Journal. I apologize for the fact that it has taken somewhat longer than usual to obtain reviews and get back to you with a decision in this case. As you will see from the reports copied below, our three referees acknowledge the potential interest and importance of this work, yet also raise a number of concerns with the experiments and their interpretation. In particular, the paper would in our view require strengthening of the physiological significance (cf. referee 1 point 1) and addition of further controls (cf. ref 3 point 1), as well as diligent discussion of potential alternative explanations (e.g. ref 1 points 2, 3). On the other hand, we feel that it will not be essential to initiate further-reaching studies on Mdy2 such as requested in ref 1 point 5.

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