论文信息 - In vivo measurements of proton relaxation times in human brain, liver, and skeletal muscle: a multicenter MRI study.

In vivo measurements of proton relaxation times in human brain, liver, and skeletal muscle: a multicenter MRI study.

Quantitative magnetic resonance imaging may offer unique potential for tissue characterization in vivo. In this connection texture analysis of quantitative MR images may be of special importance. Because evaluation of texture analysis needs large data material, multicenter approaches become mandatory. Within the frame of BME Concerted Action on Tissue Characterization by MRI and MRS, a pilot multicenter study was launched in order to evaluate the technical problems including comparability of relaxation time measurements carried out in the individual sites. Human brain, skeletal muscle, and liver were used as models. A total of 218 healthy volunteers were studied. Fifteen MRI scanners with field strength ranging from 0.08 T to 1.5 T were induced. Measurement accuracy was tested on the Eurospin relaxation time test object (TO5) and the obtained calibration curve was used for correction of the in vivo data. The results established that, by following a standardized procedure, comparable quantitative measurements can be obtained in vivo from a number of MR sites. The overall variation coefficient in vivo was in the same order of magnitude as ex vivo relaxometry. Thus, it is possible to carry out international multicenter studies on quantitative imaging, provided that quality control with respect to measurement accuracy and calibration of the MR equipments are performed.

[1] J. A. Jensen,et al. VI. A software program for exchanging MR data , 1993 .

[2] J. D. de Certaines,et al. Performance assessment and quality control in MRI by Eurospin test objects and protocols. , 1993, Magnetic resonance imaging.

[3] P A Rinck,et al. Nuclear relaxation of human brain gray and white matter: Analysis of field dependence and implications for MRI , 1990, Magnetic resonance in medicine.

[4] P. M. Walker,et al. V. Multi-center trial with protocols and prototype test objects for the assessment of MRI equipment , 1988 .

[5] C. Hardy,et al. A review of 1H nuclear magnetic resonance relaxation in pathology: are T1 and T2 diagnostic? , 1987, Medical physics.

[6] M Cortsen,et al. In vivo field dependence of proton relaxation times in human brain, liver and skeletal muscle: a multicenter study. , 1993, Magnetic resonance imaging.

[7] C. Thomsen,et al. In vivo measurements of relaxation process in the human liver by MRI. The role of respiratory gating/triggering. , 1988, Magnetic resonance imaging.

[8] T. Foster,et al. A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. , 1984, Medical physics.