Can lung MR replace lung CT?

Diseases of the respiratory system are of great importance in paediatrics. Early detection and follow-up of infectious, congenital and environmental diseases in young patients is crucial for adequate treatment and improved outcome. Here imaging techniques play an indispensable role. In the past the interest was focused on morphological aspects of pulmonary tissue. Here CT serves as the gold standard. With the development of novel CT and MRI techniques, functional pulmonary imaging became available. This field used to be the domain of nuclear medicine. In this article the techniques for cross-sectional imaging, including functional imaging of the lung are presented. The value of CT and MRI for paediatric pulmonary diseases and their potential clinical applications are compared and discussed.

[1]  N Weiler,et al.  [Ultrafast MRI of lung ventilation using hyperpolarized helium-3]. , 2000, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[2]  F. Schick,et al.  Solitary pulmonary nodules: dynamic contrast-enhanced MR imaging--perfusion differences in malignant and benign lesions. , 2004, Radiology.

[3]  Eric A Hoffman,et al.  Subsecond multisection CT of regional pulmonary ventilation. , 2002, Academic radiology.

[4]  R. Castile,et al.  Technique and clinical applications of full-inflation and end-exhalation controlled-ventilation chest CT in infants and young children , 2001, Pediatric Radiology.

[5]  H. Kauczor,et al.  Assessment of Morphological MRI for Pulmonary Changes in Cystic Fibrosis (CF) Patients: Comparison to Thin-Section CT and Chest X-ray , 2007, Investigative radiology.

[6]  H Itoh,et al.  Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. , 2000, American journal of respiratory and critical care medicine.

[7]  A R Sovijärvi,et al.  Quantitative functional lung imaging with synchrotron radiation using inhaled xenon as contrast agent. , 2001, Physics in medicine and biology.

[8]  V. Haughton,et al.  Xenon contrast enhancement in computed body tomography. , 1978, Radiology.

[9]  S J Swensen,et al.  Mosaic attenuation pattern on thin-section CT scans of the lung: differentiation among infiltrative lung, airway, and vascular diseases as a cause. , 1997, Radiology.

[10]  Tore Amundsen,et al.  Perfusion magnetic resonance imaging of the lung: Characterization of pneumonia and chronic obstructive pulmonary disease. A feasibility study , 2000, Journal of magnetic resonance imaging : JMRI.

[11]  G. Adam,et al.  MR-Bildgebung der Lungenventilation mittels aerosolierter Gadolinium-Chelate , 2003 .

[12]  Hans-Ulrich Kauczor,et al.  Evaluation of Chest Motion and Volumetry During the Breathing Cycle by Dynamic MRI in Healthy Subjects: Comparison With Pulmonary Function Tests , 2004, Investigative radiology.

[13]  M Thelen,et al.  Imaging of the lungs using 3he MRI: Preliminary clinical experience in 18 patients with and without lung disease , 1997, Journal of magnetic resonance imaging : JMRI.

[14]  M. Rominger,et al.  [Comparison between fast MR flow quantification in breathhold technique in ascending aorta and pulmonary trunc with right and left ventricular cine-MRI for the assessment of stroke volumes in healthy volunteers]. , 2002, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[15]  A. Khalil,et al.  Pulmonary arteriovenous malformations. , 2000, Chest.

[16]  H. Kauczor,et al.  Proton MRI appearance of cystic fibrosis: Comparison to CT , 2007, European Radiology.

[17]  H. Hatabu,et al.  Fast magnetic resonance imaging of the lung. , 1999, European journal of radiology.

[18]  H. Kauczor,et al.  Bronchopulmonary shunts in patients with chronic thromboembolic pulmonary hypertension: evaluation with helical CT and MR imaging. , 2002, AJR. American journal of roentgenology.

[19]  H. Kauczor,et al.  Neue Entwicklungen in der MRT des Thorax , 2001, Der Radiologe.

[20]  D. McCauley,et al.  Cystic fibrosis: scoring system with thin-section CT. , 1991, Radiology.

[21]  D. Lynch,et al.  Clinical and radiologic manifestations of hypersensitivity pneumonitis. , 2002, Journal of thoracic imaging.

[22]  H. Kauczor,et al.  Assessment of pulmonary hypertension by CT and MR imaging , 2004, European Radiology.

[23]  Robert R. Edelman,et al.  Noninvasive assessment of regional ventilation in the human lung using oxygen–enhanced magnetic resonance imaging , 1996, Nature Medicine.

[24]  H. Kauczor,et al.  Assessment of hemodynamic changes in the systemic and pulmonary arterial circulation in patients with cystic fibrosis using phase-contrast MRI , 2005, European Radiology.

[25]  Himanshu Shah,et al.  Suspected acute pulmonary embolism: evaluation with multi-detector row CT versus digital subtraction pulmonary arteriography. , 2004, Radiology.

[26]  M. Rominger,et al.  Vergleich von schneller MR-Flussmessung in Atemanhaltetechnik in Aorta ascendens und Truncus pulmonalis mit rechts- und linksventrikulärer Cine MR-Bildgebung zur Schlagvoluminabestimmung bei Probanden , 2002 .

[27]  V. Mai,et al.  MR perfusion imaging of pulmonary parenchyma using pulsed arterial spin labeling techniques: FAIRER and FAIR , 1999 .

[28]  K. Esato,et al.  Impaired respiratory mechanics in pulmonary emphysema: Evaluation with dynamic breathing MRI , 1999, Journal of magnetic resonance imaging : JMRI.

[29]  J. Murray,et al.  Aerosolized gadolinium-DTPA enhances the magnetic resonance signal of extravascular lung water. , 1987, Investigative radiology.

[30]  J. Mayo,et al.  Spiral computed tomography for acute pulmonary embolism. , 2002, Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes.

[31]  Konstantin Nikolaou,et al.  Quantification of Pulmonary Blood Flow and Volume in Healthy Volunteers by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Parallel Imaging Technique , 2004, Investigative radiology.

[32]  Matthias Niethammer,et al.  CT perfusion imaging of the lung in pulmonary embolism. , 2003, Academic radiology.

[33]  C. Meier,et al.  Cardiovascular flow measurement with phase-contrast MR imaging: basic facts and implementation. , 2002, Radiographics : a review publication of the Radiological Society of North America, Inc.

[34]  H. Kauczor,et al.  LUNGENSEQUESTRATION: EINSATZ DER MR-ANGIOGRAPHIE , 1993 .

[35]  Christina J. Herold,et al.  Cystic fibrosis: CT assessment of lung involvement in children and adults. , 1999, Radiology.

[36]  Michael Bock,et al.  Partially Parallel Three‐Dimensional Magnetic Resonance Imaging for the Assessment of Lung Perfusion – Initial Results , 2003, Investigative radiology.

[37]  B. Partik [Prospective feasibility study of chest X-ray vs. thoracic MRI in breath-hold technique at an open low-field scanner]. , 2002, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[38]  Hans-Ulrich Kauczor,et al.  Ein Auswerteprogramm zur quantitativen Untersuchung der Lungenventilation mittels dynamischer MRT von hochpolarisiertem 3He , 2004 .

[39]  Hiroto Hatabu,et al.  Dynamic oxygen‐enhanced MRI reflects diffusing capacity of the lung , 2002, Magnetic resonance in medicine.

[40]  G. Adam,et al.  [MR imaging of lung ventilation with aerosolized gadolinium-chelates]. , 2003, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[41]  J. Golden,et al.  Low-Dose, Dynamic, Expiratory Thin-Section CT of the Lungs Using a Spiral CT Scanner , 2000, Journal of thoracic imaging.

[42]  Michael Deimling,et al.  Pulmonary diffusing capacity: assessment with oxygen-enhanced lung MR imaging preliminary findings. , 2002, Radiology.

[43]  P. Jakob,et al.  Assessment of human pulmonary function using oxygen‐enhanced T1 imaging in patients with cystic fibrosis , 2004, Magnetic resonance in medicine.

[44]  K P Whittall,et al.  An analysis algorithm for measuring airway lumen and wall areas from high-resolution computed tomographic data. , 2000, American journal of respiratory and critical care medicine.

[45]  M. Frank,et al.  Small-airway diseases of the lungs: findings at expiratory CT. , 1994, AJR. American journal of roentgenology.

[46]  Hans-Ulrich Kauczor,et al.  Assessment of lung ventilation by MR imaging: current status and future perspectives , 2002, European Radiology.

[47]  P. Cluzel,et al.  Evaluation of air trapping at CT: comparison of continuous-versus suspended-expiration CT techniques. , 2000, Radiology.

[48]  Kenya Murase,et al.  Quantitative assessment of regional pulmonary perfusion in the entire lung using three‐dimensional ultrafast dynamic contrast‐enhanced magnetic resonance imaging: Preliminary experience in 40 subjects , 2004, Journal of magnetic resonance imaging : JMRI.

[49]  H. Kauczor,et al.  Paired inspiratory/expiratory spiral CT and continuous respiration cine CT in the diagnosis of tracheal instability , 2001, European Radiology.

[50]  J. Austin,et al.  Glossary of terms for CT of the lungs: recommendations of the Nomenclature Committee of the Fleischner Society. , 1996, Radiology.

[51]  Michael Bock,et al.  Regional lung perfusion: assessment with partially parallel three-dimensional MR imaging. , 2004, Radiology.

[52]  K. Kreitner,et al.  [Flow quantification of intracardiac shunt volumes using MR phase contrast technique in the breath holding phase]. , 1998, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[53]  S. Delorme,et al.  [Time-resolved multiphasic 3D MR angiography in the diagnosis of the pulmonary vascular system in children]. , 2003, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[54]  K. Kreitner,et al.  Flußquantifizierung von intrakardialen Shuntvolumina unter Verwendung der MR-Phasenkontrast-Technik in Atemanhaltephase , 1998 .

[55]  Balthasar Eberle,et al.  Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests , 2004, Investigative radiology.

[56]  中川 俊男 Pulmonary ventilation-perfusion MR imaging in clinical patients , 2004 .

[57]  M. Heike,et al.  Prospektive Machbarkeitsstudie zum Vergleich von Röntgenübersichtsaufnahme und Thorax-MRT in Atemanhaltetechnik am offenen Niederfeldgerät , 2002 .

[58]  H. Kauczor,et al.  Focal airtrapping at expiratory high-resolution CT: comparison with pulmonary function tests , 2000, European Radiology.

[59]  R R Edelman,et al.  Quantitative assessment of pulmonary perfusion with dynamic contrast‐enhanced MRI , 1999, Magnetic resonance in medicine.

[60]  Hobbs Wj,et al.  Diagnosis of pulmonary embolism with magnetic resonance angiography. , 1997 .

[61]  H. Kauczor,et al.  Magnetic resonance-compatible-spirometry: principle, technical evaluation and application , 2007, European Respiratory Journal.