Ancient DNA and the rewriting of human history: be sparing with Occam’s razor

Ancient DNA research is revealing a human history far more complex than that inferred from parsimonious models based on modern DNA. Here, we review some of the key events in the peopling of the world in the light of the findings of work on ancient DNA.

[1]  Théorie mathématique de l'hérédité mendélienne généralisée , 1939 .

[2]  H. Lehmann.  THE DISTRIBUTION OF THE HUMAN BLOOD GROUPS , 1955, The Ulster Medical Journal.

[3]  P. Menozzi,et al.  Synthetic maps of human gene frequencies in Europeans. , 1978, Science.

[4]  J. Kingman.  On the genealogy of large populations , 1982 .

[5]  J. Kingman.  On the genealogy of large populations , 1982, Journal of Applied Probability.

[6]  M. Stoneking,et al.  Mitochondrial DNA and human evolution , 1987, Nature.

[7]  A. Thorne,et al.  The multiregional evolution of humans. , 1992, Scientific American.

[8]  T. Disotell.  Human evolution: Origins of modern humans still look recent , 1999, Current Biology.

[9]  D. Goldstein,et al.  Genetic evidence for different male and female roles during cultural transitions in the British Isles , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Lounès Chikhi,et al.  Y genetic data support the Neolithic demic diffusion model , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[11]  S. Pääbo,et al.  No Evidence of Neandertal mtDNA Contribution to Early Modern Humans , 2004, PLoS biology.

[12]  L. Excoffier,et al.  Modern Humans Did Not Admix with Neanderthals during Their Range Expansion into Europe , 2004, PLoS biology.

[13]  M. Hammer,et al.  Deep Haplotype Divergence and Long-range Linkage Disequilibrium at Xp21.1 Provide Evidence That Humans Descend from a Structured Ancestral Population Porting the " Recent African Replacement " (rar) Model of Human Origins. the Rar Model Posits That Amh , 2022 .

[14]  Vincent Plagnol,et al.  Possible Ancestral Structure in Human Populations , 2006, PLoS genetics.

[15]  Damir Marjanovic,et al.  Y-chromosomal evidence of the cultural diffusion of agriculture in southeast Europe , 2009, European Journal of Human Genetics.

[16]  Philip L. F. Johnson,et al.  Genetic history of an archaic hominin group from Denisova Cave in Siberia , 2010, Nature.

[17]  Asan,et al.  Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude , 2010, Science.

[18]  A. Krogh,et al.  Ancient human genome sequence of an extinct Palaeo-Eskimo , 2010, Nature.

[19]  Philip L. F. Johnson,et al.  A Draft Sequence of the Neandertal Genome , 2010, Science.

[20]  Guido Barbujani,et al.  A Predominantly Neolithic Origin for European Paternal Lineages , 2010, PLoS biology.

[21]  D. Reich,et al.  Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. , 2011, American journal of human genetics.

[22]  D. Reich,et al.  The Date of Interbreeding between Neandertals and Modern Humans , 2012, PLoS genetics.

[23]  Natalie M. Myres,et al.  New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing , 2012, Nature Communications.

[24]  Anders Eriksson,et al.  Effect of ancient population structure on the degree of polymorphism shared between modern human populations and ancient hominins , 2012, Proceedings of the National Academy of Sciences.

[25]  M. Slatkin,et al.  Ancient structure in Africa unlikely to explain Neanderthal and non-African genetic similarity. , 2012, Molecular biology and evolution.

[26]  Mark D Shriver,et al.  The timing of pigmentation lightening in Europeans. , 2013, Molecular biology and evolution.

[27]  Philip L. F. Johnson,et al.  The complete genome sequence of a Neanderthal from the Altai Mountains , 2013 .

[28]  Joshua M. Akey,et al.  Resurrecting Surviving Neandertal Lineages from Modern Human Genomes , 2014, Science.

[29]  Swapan Mallick,et al.  The genomic landscape of Neanderthal ancestry in present-day humans. , 2016 .

[30]  Mattias Jakobsson,et al.  The genome of a Late Pleistocene human from a Clovis burial site in western Montana , 2014, Nature.

[31]  Heng Li,et al.  Genome sequence of a 45,000-year-old modern human from western Siberia , 2014, Nature.

[32]  Bonnie Berger,et al.  Ancient human genomes suggest three ancestral populations for present-day Europeans , 2013, Nature.

[33]  Michael C. Westaway,et al.  Genomic structure in Europeans dating back at least 36,200 years , 2014, Science.

[34]  R. Mägi,et al.  Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans , 2013, Nature.

[35]  R. Durbin,et al.  Inferring human population size and separation history from multiple genome sequences , 2014, Nature Genetics.

[36]  Qiaomei Fu,et al.  A mitochondrial genome sequence of a hominin from Sima de los Huesos , 2013, Nature.

[37]  Asan,et al.  Altitude adaptation in Tibet caused by introgression of Denisovan-like DNA , 2014, Nature.

[38]  Arcadi Navarro,et al.  Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European , 2014, Nature.

[39]  Michael C. Westaway,et al.  A recent bottleneck of Y chromosome diversity coincides with a global change in culture , 2015, Genome research.

[40]  Swapan Mallick,et al.  Massive migration from the steppe was a source for Indo-European languages in Europe , 2015, Nature.

[41]  R. Durbin,et al.  Tracing the Route of Modern Humans out of Africa by Using 225 Human Genome Sequences from Ethiopians and Egyptians , 2015, American journal of human genetics.

[42]  J. Akey,et al.  Complex history of admixture between modern humans and Neandertals. , 2015, American journal of human genetics.

[43]  Søren Brunak,et al.  Population genomics of Bronze Age Eurasia , 2015, Nature.

[44]  D. Reich,et al.  Genetic evidence for two founding populations of the Americas , 2015, Nature.

[45]  Swapan Mallick,et al.  An early modern human from Romania with a recent Neanderthal ancestor , 2015, Nature.

[46]  Mattias Jakobsson,et al.  Genomic evidence for the Pleistocene and recent population history of Native Americans , 2015, Science.

[47]  Bernard Y. Kim,et al.  Selection and reduced population size cannot explain higher amounts of Neandertal ancestry in East Asian than in European human populations. , 2015, American journal of human genetics.

[48]  M. Jobling,et al.  Large-scale recent expansion of European patrilineages shown by population resequencing , 2015, Nature Communications.

[49]  Cristina E. Valdiosera,et al.  The ancestry and affiliations of Kennewick Man , 2015, Nature.

[50]  D. Reich,et al.  Genome-wide patterns of selection in 230 ancient Eurasians , 2015, Nature.