Scan-Based Flow Modelling in Human Upper Airways

In this chapter, an overview of a scan-based modelling technique to investigate the air flow and heat transfer in a human upper respiratory system is presented. The scan-based modelling process includes image segmentation, producing a valid mesh for analysis and flow modelling. All the three aspects are briefly discussed in this work.

[1]  Ted B. Martonen,et al.  Three-dimensional computer modeling of the human upper respiratory tract , 2007, Cell Biochemistry and Biophysics.

[2]  Pascal Frey Generation and adaptation of computational surface meshes from discrete anatomical data , 2004 .

[3]  Wolfgang A. Wall,et al.  A computational strategy for prestressing patient‐specific biomechanical problems under finite deformation , 2010 .

[4]  Desheng Wang,et al.  Tetrahedral mesh generation and optimization based on centroidal Voronoi tessellations , 2003 .

[5]  Y. Zhao,et al.  Inspiratory and expiratory steady flow analysis in a model symmetrically bifurcating airway. , 1997, Journal of biomechanical engineering.

[6]  V. Kulish Human respiration : anatomy and physiology, mathematical modeling, numerical simulation and applications , 2006 .

[7]  P COLE,et al.  Some Aspects of Temperature, Moisture And Heat Relationships in The Upper Respiratory Tract , 1953, The Journal of Laryngology & Otology.

[8]  P WEBB,et al.  Air temperatures in respiratory tracts of resing subjects in cold. , 1951, Journal of applied physiology.

[9]  Xianghua Xie,et al.  Modelling pipeline for subject‐specific arterial blood flow—A review , 2011 .

[10]  W Hofmann,et al.  Modeling techniques for inhaled particle deposition: the state of the art. , 1996, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[11]  O. Zienkiewicz,et al.  A general algorithm for compressible and incompressible flow—Part I. the split, characteristic‐based scheme , 1995 .

[12]  Chris Lacor,et al.  Fluid flow and particle deposition analysis in a realistic extrathoracic airway model using unstructured grids , 2007 .

[13]  Nigel P. Weatherill,et al.  EQSM: An efficient high quality surface grid generation method based on remeshing , 2006 .

[14]  Jianren Fan,et al.  Large eddy simulation of inhaled particle deposition within the human upper respiratory tract , 2007 .

[15]  Seung-Kyu Chung,et al.  Digital particle image velocimetry studies of nasal airflow , 2008, Respiratory Physiology & Neurobiology.

[16]  Nigel P. Weatherill,et al.  A stitching method for the generation of unstructured meshes for use with co-volume solution techniques , 2006 .

[17]  A S Wexler,et al.  Detailed flow patterns in the nasal cavity. , 2000, Journal of applied physiology.

[18]  Warren H. Finlay,et al.  On the suitability of k–ε turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment , 2000 .

[19]  E Chernyaev,et al.  Marching cubes 33 : construction of topologically correct isosurfaces , 1995 .

[20]  E. Hoffman,et al.  Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways , 2007, Respiratory Physiology & Neurobiology.

[21]  Ramon Codina,et al.  Numerical comparison of CBS and SGS as stabilization techniques for the incompressible Navier–Stokes equations , 2006 .

[22]  L. A. Engel,et al.  Respiratory movements of the vocal cords. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[23]  David Elad,et al.  The Air-Conditioning Capacity of the Human Nose , 2005, Annals of Biomedical Engineering.

[24]  Indu Ayappa,et al.  The upper airway in sleep: physiology of the pharynx. , 2003, Sleep medicine reviews.

[25]  David Elad,et al.  Air-conditioning in the human nasal cavity , 2008, Respiratory Physiology & Neurobiology.

[26]  X Y Luo,et al.  LES modelling of flow in a simple airway model. , 2004, Medical engineering & physics.

[27]  R. C. Schroter,et al.  Transport Phenomena in the Human Nasal Cavity: A Computational Model , 1998, Annals of Biomedical Engineering.

[28]  William H. Frey,et al.  Mesh relaxation: A new technique for improving triangulations , 1991 .

[29]  D. Doorly,et al.  Inflow boundary profile prescription for numerical simulation of nasal airflow , 2010, Journal of The Royal Society Interface.

[30]  P. Nithiarasu,et al.  Laminar and turbulent flow calculations through a model human upper airway using unstructured meshes , 2006 .

[31]  C Renotte,et al.  Numerical 3D analysis of oscillatory flow in the time-varying laryngeal channel. , 2000, Journal of biomechanics.

[32]  Thomas Heistracher,et al.  Air Flow and Particle Deposition Patterns in Bronchial Airway Bifurcations: The Effect of Different CFD Models and Bifurcation Geometries , 1996 .

[33]  Fausto Arpino,et al.  Explicit and semi-implicit CBS procedures for incompressible viscous flows , 2006 .

[34]  Nigel P. Weatherill,et al.  Automatic Unstructured Surface Mesh Generation for Complex Configurations , 2004 .

[35]  K. Morgan,et al.  Three‐dimensional incompressible flow calculations using the characteristic based split (CBS) scheme , 2004 .

[36]  Xiaoyu Luo,et al.  Three-dimensional collapse and steady flow in thick-walled flexible tubes , 2005 .

[37]  Shanmugam Murugappan,et al.  Validation of computational fluid dynamics methodology used for human upper airway flow simulations. , 2009, Journal of biomechanics.

[38]  Perumal Nithiarasu,et al.  Computational flow studies in a subject‐specific human upper airway using a one‐equation turbulence model. Influence of the nasal cavity , 2011 .

[39]  Jerry L. Prince,et al.  Snakes, shapes, and gradient vector flow , 1998, IEEE Trans. Image Process..

[40]  Norman Chigier,et al.  A Numerical and Experimental Study of Spray Dynamics in a Simple Throat Model , 2002 .

[41]  Perumal Nithiarasu,et al.  An artificial compressibility based characteristic based split (CBS) scheme for steady and unsteady turbulent incompressible flows , 2006 .

[42]  Tony W. H. Sheu,et al.  Finite element analysis of particle motion in steady inspiratory airflow , 2002 .

[43]  Debasis Majumdar,et al.  X‐ray photoelectron spectroscopic studies on yttria, zirconia, and yttria‐stabilized zirconia , 1991 .

[44]  Kenneth R. Lutchen,et al.  An Anatomically Based Hybrid Computational Model of the Human Lung and its Application to Low Frequency Oscillatory Mechanics , 2006, Annals of Biomedical Engineering.

[45]  N. Weatherill,et al.  Efficient three‐dimensional Delaunay triangulation with automatic point creation and imposed boundary constraints , 1994 .

[46]  Chris Lacor,et al.  Tracheal stenosis: a flow dynamics study. , 2007, Journal of applied physiology.

[47]  Peter J. Hunter,et al.  Modeling Water Vapor and Heat Transfer in the Normal and the Intubated Airways , 2004, Annals of Biomedical Engineering.

[48]  J. Grotberg,et al.  BIOFLUID MECHANICS IN FLEXIBLE TUBES , 2001 .

[49]  Andrew Pollard,et al.  Experimental measurements and computational modeling of the flow field in an idealized human oropharynx , 2003 .

[50]  G. Degrez,et al.  Numerical modeling of steady inspiratory airflow through a three-generation model of the human central airways. , 1997, Journal of biomechanical engineering.

[51]  Shanmugam Murugappan,et al.  Large Eddy Simulation and Reynolds-Averaged Navier-Stokes modeling of flow in a realistic pharyngeal airway model: an investigation of obstructive sleep apnea. , 2008, Journal of biomechanics.

[52]  M. Malvè,et al.  FSI Analysis of the Coughing Mechanism in a Human Trachea , 2010, Annals of Biomedical Engineering.

[53]  Daniel P. Huttenlocher,et al.  Distance Transforms of Sampled Functions , 2012, Theory Comput..

[54]  S. Bodner,et al.  The relative importance of septal and nasal valvular surgery in correcting airway obstruction in primary and secondary rhinoplasty. , 1996, Plastic and reconstructive surgery.

[55]  K. Englmeier,et al.  Aerodynamics and aerosol particle deaggregation phenomena in model oral-pharyngeal cavities , 1996 .

[56]  Edwards,et al.  Aerosol particle transport and deaggregation phenomena in the mouth and throat. , 1997, Advanced drug delivery reviews.

[57]  E G Cravalho,et al.  Finite difference analysis of respiratory heat transfer. , 1986, Journal of applied physiology.

[58]  Soo-Jin Jeong,et al.  Numerical investigation on the flow characteristics and aerodynamic force of the upper airway of patient with obstructive sleep apnea using computational fluid dynamics. , 2007, Medical engineering & physics.

[59]  Jody Kreiman,et al.  Modeling Measured Glottal Volume Velocity Waveforms , 2003, The Annals of otology, rhinology, and laryngology.

[60]  J. M. Fouke,et al.  Dilating forces on the upper airway of anesthetized dogs. , 1985, Journal of applied physiology.

[61]  W M Luxford,et al.  Laryngeal Stenosis from Endotracheal Intubation , 1980, The Annals of otology, rhinology, and laryngology.

[62]  Guilherme J M Garcia,et al.  Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. , 2007, Journal of applied physiology.

[63]  J Peiró Surface Grid Generation , 1998 .

[64]  Rainald Löhner,et al.  Special issue on patient‐specific computational modelling , 2010 .

[65]  William E. Lorensen,et al.  Marching cubes: a high resolution 3D surface construction algorithm , 1996 .

[66]  Clement Kleinstreuer,et al.  Species heat and mass transfer in a human upper airway model , 2003 .

[67]  Ted B. Martonen,et al.  3-D Particle transport within the human upper respiratory tract , 2002 .

[68]  P. Spalart A One-Equation Turbulence Model for Aerodynamic Flows , 1992 .

[69]  P. Nithiarasu An efficient artificial compressibility (AC) scheme based on the characteristic based split (CBS) method for incompressible flows , 2003 .

[70]  Daniel Isabey,et al.  In Vitro Experiments and Numerical Simulations of Airflow in Realistic Nasal Airway Geometry , 2006, Annals of Biomedical Engineering.

[71]  R. Löhner,et al.  Fast numerical solutions of patient‐specific blood flows in 3D arterial systems , 2010, International journal for numerical methods in biomedical engineering.

[72]  Xianghua Xie,et al.  MAC: Magnetostatic Active Contour Model , 2008, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[73]  Nigel P. Weatherill,et al.  Steady flow through a realistic human upper airway geometry , 2008 .

[74]  R. C. Schroter,et al.  Mechanics of airflow in the human nasal airways , 2008, Respiratory Physiology & Neurobiology.

[75]  R. Löhner Regridding Surface Triangulations , 1996 .

[76]  Clement Kleinstreuer,et al.  Laminar-to-turbulent fluid-particle flows in a human airway model , 2003 .

[77]  Gerhard Rettinger,et al.  A Numerical Simulation of Intranasal Air Temperature During Inspiration , 2004, The Laryngoscope.

[78]  Imre Balásházy,et al.  Inspiratory Deposition Efficiency of Ultrafine Particles in a Human Airway Bifurcation Model , 2003 .

[79]  J. Peiro,et al.  On the segmentation of vascular geometries from medical images , 2010 .

[80]  Xianghua Xie,et al.  Geometrically Induced Force Interaction for Three-Dimensional Deformable Models , 2011, IEEE Transactions on Image Processing.

[81]  Jean F. A. Pruyn,et al.  Physical and Psychosocial Correlates of Head and Neck Cancer: A Review of the Literature , 1999, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[82]  T. Sheldon,et al.  Health effects of obstructive sleep apnoea and the effectiveness of continuous positive airways pressure: a systematic review of the research evidence , 1997, BMJ.

[83]  R C Schroter,et al.  Experimental investigation of nasal airflow , 2008, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[84]  K P Strohl,et al.  Pressure-volume behavior of the upper airway. , 1986, Journal of applied physiology.

[85]  J W Kaufman,et al.  Predicted combustion product deposition in the human airway. , 1996, Toxicology.

[86]  O. C. Zienkiewicz,et al.  The Finite Element Method for Fluid Dynamics , 2005 .

[87]  T. Nishino,et al.  Coordination of swallowing and respiration in unconscious subjects. , 1991, Journal of applied physiology.

[88]  P. Ebden,et al.  Comparison of two high dose corticosteroid aerosol treatments, beclomethasone dipropionate (1500 micrograms/day) and budesonide (1600 micrograms/day), for chronic asthma. , 1986, Thorax.