Cardiac Autonomic Regulation under Hypnosis Assessed by Heart Rate Variability: Spectral Analysis and Fractal Complexity

Objective: This study examined the effects of hypnosis on autonomic cardiac control. We hypothesized a modification of autonomic modulation of the heart rate with an enhanced vagal tone during hypnosis compared to baseline. Methods: In 12 healthy subjects (6 men and 6 women, 22.2 ± 1.0 years of age) ECG was recorded at baseline and during hypnosis. Heart rate variability parameters were obtained in the frequency domain (LFnu: low frequency normalized units, and HFnu: high frequency normalized units) and from nonlinear analysis methods (detrended fluctuation analysis, DFA). Results: Compared to the control condition, hypnosis showed a significantly decreased LFnu, a significantly increased HFnu, and a significantly decreased LF/HF. DFA showed a significantly decreased short-range similarity. Heart rate remained unchanged. Conclusion: Autonomic cardiac tone is significantly modified during hypnosis by shifting the balance of the sympathovagal interaction toward an enhanced parasympathetic modulation, accompanied by a reduction of the sympathetic tone and a decreased short-range similarity but without a concomitant change in heart rate. Central and secondary autonomous nervous system changes induced by hypnosis are a possible explanation for our results. Another highly probable explanation is given by a variation in the depth of respiration. Hypnosis appears to prevent the autonomic responses expected during neutral stimulation.

[1]  H. Huikuri,et al.  Time domain, geometrical and frequency domain analysis of cardiac vagal outflow: effects of various respiratory patterns. , 2001, Clinical physiology.

[2]  J. Gruzelier.  The role of psychological intervention in modulating aspects of immune function in relation to health and well-being. , 2002, International review of neurobiology.

[3]  G. Montgomery,et al.  A meta-analysis of hypnotically induced analgesia: How effective is hypnosis? , 2000, The International journal of clinical and experimental hypnosis.

[4]  J. Kiecolt-Glaser,et al.  Hypnosis as a modulator of cellular immune dysregulation during acute stress. , 2001, Journal of consulting and clinical psychology.

[5]  G. Carli,et al.  Different strategies of modulation can be operative during hypnotic analgesia: a neurophysiological study , 1998, Pain.

[6]  P. Whorwell,et al.  Physiological effects of emotion: assessment via hypnosis , 1992, The Lancet.

[7]  G. Breithardt,et al.  Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. , 1996 .

[8]  H Ector,et al.  The analysis of heart rate variability in unrestrained rats. Validation of method and results. , 1999, Computer methods and programs in biomedicine.

[9]  W. M. Gonsalkorale.  The use of hypnosis in medicine: the possible pathways involved , 1996, European journal of gastroenterology & hepatology.

[10]  P. Whorwell,et al.  Long-term improvement in functional dyspepsia using hypnotherapy. , 2002, Gastroenterology.

[11]  H Ector,et al.  Heart rate variability and heart rate in healthy volunteers. Is the female autonomic nervous system cardioprotective? , 1998, European heart journal.

[12]  Dirk Ramaekers,et al.  EFFECTS OF AUTONOMIC BLOCKADE ON NON‐LINEAR CARDIOVASCULAR VARIABILITY INDICES IN RATS , 2006, Clinical and experimental pharmacology & physiology.

[13]  P. Novak,et al.  Influence of respiration on heart rate and blood pressure fluctuations. , 1993, Journal of applied physiology.

[14]  Jeffrey M. Hausdorff,et al.  Fractal mechanisms and heart rate dynamics. Long-range correlations and their breakdown with disease. , 1995, Journal of electrocardiology.

[15]  P. Whorwell,et al.  Long term benefits of hypnotherapy for irritable bowel syndrome , 2003, Gut.

[16]  Jeffrey M. Hausdorff,et al.  Fractal dynamics in physiology: Alterations with disease and aging , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[17]  N. Covino,et al.  Empirical findings on the use of hypnosis in medicine: A critical review , 2000, The International journal of clinical and experimental hypnosis.

[18]  A. Simoni,et al.  Autonomic and EEG correlates of emotional imagery in subjects with different hypnotic susceptibility , 2003, Brain Research Bulletin.

[19]  M. Jensen,et al.  Hypnosis and clinical pain. , 2003, Psychological bulletin.

[20]  W. M. Gonsalkorale.  Gut-Directed Hypnotherapy: The Manchester Approach for Treatment of Irritable Bowel Syndrome , 2006, The International journal of clinical and experimental hypnosis.

[21]  W J Ray,et al.  EEG activity and heart rate during recall of emotional events in hypnosis: relationships with hypnotizability and suggestibility. , 1998, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[22]  H. Stanley,et al.  Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. , 1995, Chaos.

[23]  C. Degueldre,et al.  Functional neuroanatomy of hypnotic state , 1999, Biological Psychiatry.

[24]  The Neurobiology of Pain, Affect and Hypnosis , 2004, The American journal of clinical hypnosis.

[25]  Keith Willson,et al.  Relationship between detrended fluctuation analysis and spectral analysis of heart-rate variability. , 2002, Physiological measurement.

[26]  Ary L. Goldberger.  Nonlinear dynamics, fractals and chaos: Applications to cardiac electrophysiology , 2006, Annals of Biomedical Engineering.

[27]  J. Thayer,et al.  Daily worry is related to low heart rate variability during waking and the subsequent nocturnal sleep period. , 2007, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[28]  V. De Pascalis,et al.  EEG asymmetry and heart rate during experience of hypnotic analgesia in high and low hypnotizables. , 1996, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[29]  A. M. Brown,et al.  Sustained attentional and disattentional abilities: differences between low and highly hypnotizable persons. , 1993, Journal of abnormal psychology.

[30]  T. Gnecchi-Ruscone,et al.  Effect of hypnotic sedation during percutaneous transluminal coronary angioplasty on myocardial ischemia and cardiac sympathetic drive. , 2004, The American journal of cardiology.

[31]  P. Whorwell.  HYPNOTHERAPY IN IRRITABLE BOWEL SYNDROME , 1989, The Lancet.

[32]  K. Quigley,et al.  Cardiovascular reactivity during hypnosis and hypnotic susceptibility: Three studies of heart rate variability , 2000, The International journal of clinical and experimental hypnosis.

[33]  P. M. Penna,et al.  40-Hz EEG activity during hypnotic induction and hypnotic testing. , 1990, The International journal of clinical and experimental hypnosis.

[34]  W. Whitehead,et al.  Hypnosis Treatment for Severe Irritable Bowel Syndrome: Investigation of Mechanism and Effects on Symptoms , 2002, Digestive Diseases and Sciences.

[35]  V. De Pascalis,et al.  Psychophysiological correlates of hypnosis and hypnotic susceptibility. , 1999, The International journal of clinical and experimental hypnosis.

[36]  J. Hayano,et al.  Effect of relaxation training on cardiac parasympathetic tone. , 1994, Psychophysiology.

[37]  S Cerutti,et al.  Autonomic changes during hypnosis: a heart rate variability power spectrum analysis as a marker of sympatho-vagal balance. , 1994, The International journal of clinical and experimental hypnosis.

[38]  J. Laurence,et al.  A multivariate approach to the prediction of hypnotic susceptibility. , 1996, The International journal of clinical and experimental hypnosis.

[39]  R. Nadon,et al.  Multiple predictors of hypnotic susceptibility. , 1987, Journal of personality and social psychology.

[40]  W. Coe,et al.  Physiological responsiveness during hypnosis. , 1990, The International journal of clinical and experimental hypnosis.

[41]  A E Aubert,et al.  Respiratory modulation of cardiovascular rhythms before and after short‐duration human spaceflight , 2007, Acta physiologica.

[42]  Brunello Ghelarducci,et al.  Hypnotizability-dependent modulation of the changes in heart rate control induced by upright stance , 2008, Brain Research Bulletin.

[43]  A Gemignani,et al.  Human hypnosis: autonomic and electroencephalographic correlates of a guided multimodal cognitive-emotional imagery , 2003, Neuroscience Letters.

[44]  Frank Beckers,et al.  Aging and nonlinear heart rate control in a healthy population. , 2006, American journal of physiology. Heart and circulatory physiology.

[45]  A Gemignani,et al.  Changes in autonomic and EEG patterns induced by hypnotic imagination of aversive stimuli in man , 2000, Brain Research Bulletin.

[46]  E Picano,et al.  Hypnosis effect on RR interval and blood pressure variability. , 1996, Clinical science.

[47]  M. Bushnell,et al.  Hypnosis Modulates Activity in Brain Structures Involved in the Regulation of Consciousness , 2002, Journal of Cognitive Neuroscience.

[48]  S. Lynn,et al.  The fantasy-prone person: hypnosis, imagination, and creativity. , 1986, Journal of personality and social psychology.

[49]  D. Malaspina,et al.  Nonlinear Complexity and Spectral Analyses of Heart Rate Variability in Medicated and Unmedicated Patients with Schizophrenia1 , 2005, Neuropsychobiology.

[50]  A. Aubert,et al.  Neurocardiology: the benefits of irregularity. The basics of methodology, physiology and current clinical applications. , 1999, Acta cardiologica.

[51]  G. Hole,et al.  Autonomic Profile under Hypnosis as Assessed by Heart Rate Variability and Spectral Analysis , 2001, Pharmacopsychiatry.

[52]  Alberto Malliani,et al.  Principles of Cardiovascular Neural Regulation in Health and Disease , 2012, Basic Science for the Cardiologist.

[53]  M. Bushnell,et al.  Pain affect encoded in human anterior cingulate but not somatosensory cortex. , 1997, Science.

[54]  E. Hilgard,et al.  The Stanford Hypnotic Arm Levitation Induction and Test (SHALIT): a six-minute hypnotic induction and measurement scale. , 1979, The International journal of clinical and experimental hypnosis.

[55]  M. Bushnell,et al.  Dissociation of sensory and affective dimensions of pain using hypnotic modulation , 1999, Pain.