Speciation of arsenic compounds by ion-exchange HPLC-ICP-MS with different nebulizers

For the purpose of environmental biomonitoring analytical procedures for the sensitive and efficient speciation of the arsenic species As(III), As(V), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), trimethylarsine oxide (TMAO), tetramethylarsonium ion (Tetra), arsenobetaine and arsenocholine have been optimized. The influence of different nebulizers, in particular cross flow and hydraulic high pressure, on the analytical performance and quality parameters such as limit of detection and reproducibility was investigated. LODs in the range of a few pg or even below were achieved. The HPLC-ICP-MS procedures were validated by using reference materials.

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