Magnetic resonance-guided focused ultrasound surgery: Part 2: A review of current and future applications.

Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a novel combination of technologies that is actively being realized as a noninvasive therapeutic tool for a myriad of conditions. These applications are reviewed with a focus on neurological use. A combined search of PubMed and MEDLINE was performed to identify the key events and current status of MRgFUS, with a focus on neurological applications. MRgFUS signifies a potentially ideal device for the treatment of neurological diseases. As it is nearly real time, it allows monitored provision of treatment location and energy deposition; is noninvasive, thereby limiting or eliminating disruption of normal tissue; provides focal delivery of therapeutic agents; enhances radiation delivery; and permits modulation of neural function. Multiple clinical applications are currently in clinical use and many more are under active preclinical investigation. The therapeutic potential of MRgFUS is expanding rapidly. Although clinically in its infancy, preclinical and early-phase I clinical trials in neurosurgery suggest a promising future for MRgFUS. Further investigation is necessary to define its true potential and impact.

[1]  D. Hanley,et al.  Spontaneous Intracerebral Hemorrhage , 2012, Neuromethods.

[2]  Clayton M. Christensen.  The Innovator's Dilemma: When New Technologies Cause Great Firms to Fail , 2013 .

[3]  Robin O. Cleveland,et al.  Physics of Shock‐Wave Lithotripsy , 2012 .

[4]  Chung Yin Kong,et al.  Quality-of-life assessment of fibroid treatment options and outcomes. , 2011, Radiology.

[5]  Jong-Hwan Lee,et al.  Focused ultrasound modulates region-specific brain activity , 2011, NeuroImage.

[6]  E. Bouwsma,et al.  Magnetic resonance-guided focused ultrasound surgery for leiomyoma-associated infertility , 2011, Fertility and sterility.

[7]  G. Russo,et al.  Can magnetic resonance image-guided focused ultrasound surgery replace local oncology treatments? A review , 2011, Tumori.

[8]  G. Russo,et al.  Can magnetic resonance image-guided focused ultrasound surgery replace local oncology treatments? A review , 2011 .

[9]  L. Regan,et al.  Successful in vitro fertilization pregnancy following magnetic resonance‐guided focused ultrasound surgery for uterine fibroids , 2011, The journal of obstetrics and gynaecology research.

[10]  Byoung-Kyong Min,et al.  Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity , 2011, BMC Neuroscience.

[11]  A. Sarvazyan,et al.  Biomedical applications of radiation force of ultrasound: historical roots and physical basis. , 2010, Ultrasound in medicine & biology.

[12]  S. Tillery,et al.  Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits , 2010, Neuron.

[13]  S. Lee,et al.  Pregnancy and Natural Delivery Following Magnetic Resonance Imaging-Guided Focused Ultrasound Surgery of Uterine Myomas , 2010, Yonsei medical journal.

[14]  K. Hynynen,et al.  Transcranial Magnetic Resonance Imaging– Guided Focused Ultrasound Surgery of Brain Tumors: Initial Findings in 3 Patients , 2010, Neurosurgery.

[15]  A. Morel,et al.  High‐intensity focused ultrasound for noninvasive functional neurosurgery , 2009, Annals of neurology.

[16]  A. Dumont,et al.  SONOTHROMBOLYSIS: AN EMERGING MODALITY FOR THE MANAGEMENT OF STROKE , 2009, Neurosurgery.

[17]  K. Funaki,et al.  Clinical outcomes of magnetic resonance‐guided focused ultrasound surgery for uterine myomas: 24‐month follow‐up , 2009, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[18]  K. Hynynen,et al.  Focused ultrasound effects on nerve action potential in vitro. , 2009, Ultrasound in medicine & biology.

[19]  Jay Jagannathan,et al.  HIGH‐INTENSITY FOCUSED ULTRASOUND SURGERY OF THE BRAIN: PART 1—A HISTORICAL PERSPECTIVE WITH MODERN APPLICATIONS , 2009, Neurosurgery.

[20]  M. Kaste,et al.  Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. , 2008, The New England journal of medicine.

[21]  Shahram Vaezy,et al.  Effects of high‐intensity focused ultrasound on nerve conduction , 2008, Muscle & nerve.

[22]  F. Jolesz.  MRI-guided focused ultrasound surgery. , 2007, Annual review of medicine.

[23]  Pei Zhong,et al.  Investigation of HIFU-induced anti-tumor immunity in a murine tumor model , 2007, Journal of Translational Medicine.

[24]  Laura Curiel,et al.  Control of prostate cancer by transrectal HIFU in 227 patients. , 2007, European urology.

[25]  Ronald A. Roy,et al.  Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU) , 2007, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[26]  Constantin Coussios,et al.  High intensity focused ultrasound: Physical principles and devices , 2007, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[27]  Gregory T. Clement,et al.  Clinical applications of focused ultrasound—The brain , 2007, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[28]  J. Kennedy,et al.  High intensity focused ultrasound in the treatment of abdominal and gynaecological diseases , 2007, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[29]  S. Maier,et al.  MAGNETIC RESONANCE IMAGING‐GUIDED, HIGH‐INTENSITY FOCUSED ULTRASOUND FOR BRAIN TUMOR THERAPY , 2006, Neurosurgery.

[30]  Shahram Vaezy,et al.  Image-Guided High-Intensity Focused Ultrasound for Conduction Block of Peripheral Nerves , 2006, Annals of Biomedical Engineering.

[31]  D. Kopelman,et al.  MR-guided focused ultrasound surgery (MRgFUS) for the palliation of pain in patients with bone metastases--preliminary clinical experience. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[32]  Kullervo Hynynen,et al.  Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. , 2006, Radiology.

[33]  Kullervo Hynynen,et al.  Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. , 2006, European journal of radiology.

[34]  Manabu Kinoshita,et al.  Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Sharon Thomsen,et al.  Magnetic resonance-guided focused ultrasound surgery of breast cancer: reliability and effectiveness. , 2006, Journal of the American College of Surgeons.

[36]  Shin Jung,et al.  Focused Ultrasound Surgery for the Treatment of Recurrent Anaplastic Astrocytoma: A Preliminary Report , 2006 .

[37]  Lawrence A Crum,et al.  Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom. , 2006, The Journal of the Acoustical Society of America.

[38]  K. Hynynen,et al.  Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. , 2006, Biochemical and biophysical research communications.

[39]  S. Umemura,et al.  In vivo acceleration of ultrasonic tissue heating by microbubble agent , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[40]  Natalia Vykhodtseva,et al.  MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. , 2005, Ultrasound in medicine & biology.

[41]  F V Gleeson,et al.  The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population , 2005, British Journal of Cancer.

[42]  C. Cain,et al.  Effects of contrast agent infusion rates on thresholds for tissue damage produced by single exposures of high-intensity ultrasound , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[43]  S Chen,et al.  MRI-guided focused ultrasound treatment of uterine fibroids. , 2005, Issues in emerging health technologies.

[44]  Thierry Bettinger,et al.  Plasma membrane poration induced by ultrasound exposure: implication for drug delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[45]  J. Xie,et al.  Pulsed high-intensity focused ultrasound enhances systemic administration of naked DNA in squamous cell carcinoma model: initial experience. , 2005, Radiology.

[46]  Wen-Zhi Chen,et al.  Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization. , 2005, Radiology.

[47]  F. Rosendaal,et al.  The Effects of a Smoking Cessation Intervention on 14.5-Year Mortality , 2005, Annals of Internal Medicine.

[48]  Victor Frenkel,et al.  Delivery of systemic chemotherapeutic agent to tumors by using focused ultrasound: study in a murine model. , 2005, Radiology.

[49]  A. Alexandrov,et al.  Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. , 2004, The New England journal of medicine.

[50]  K. Hynynen,et al.  Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. , 2004, Ultrasound in medicine & biology.

[51]  A. Alexandrov,et al.  CLOTBUST: Design of a Randomized Trial of Ultrasound‐Enhanced Thrombolysis for Acute Ischemic Stroke , 2004, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[52]  Bernhard Walter,et al.  High-intensity focused ultrasound for the treatment of localized prostate cancer: 5-year experience. , 2004, Urology.

[53]  J. Bai,et al.  A microbubble agent improves the therapeutic efficiency of high intensity focused ultrasound: a rabbit kidney study , 2004, Urological Research.

[54]  Wen-zhi Chen,et al.  A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer , 2003, British Journal of Cancer.

[55]  Yuan-feng Yang,et al.  [An experimental study on high intensity focused ultrasound combined with mitomycin treatment of bladder tumor]. , 2003, Zhonghua wai ke za zhi [Chinese journal of surgery].

[56]  C. Cain,et al.  Microbubble-enhanced cavitation for noninvasive ultrasound surgery , 2003, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[57]  N. Pouratian,et al.  Update on management of intracerebral hemorrhage. , 2003, Neurosurgical focus.

[58]  Wen-zhi Chen,et al.  [High intensity focused ultrasound therapy combined with transcatheter arterial chemoembolization for advanced hepatocellular carcinoma]. , 2003, Zhonghua zhong liu za zhi [Chinese journal of oncology].

[59]  E. Winer,et al.  Central nervous system metastases in women who receive trastuzumab‐based therapy for metastatic breast carcinoma , 2003, Cancer.

[60]  D. Gianfelice,et al.  MR imaging-guided focused US ablation of breast cancer: histopathologic assessment of effectiveness-- initial experience. , 2003, Radiology.

[61]  Kullervo Hynynen,et al.  MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. , 2003, Radiology.

[62]  K Hynynen,et al.  MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh. , 2003, Physics in medicine and biology.

[63]  P. J. Hoopes,et al.  Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia , 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[64]  Wen-zhi Chen,et al.  Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound. , 2001, Ultrasound in medicine & biology.

[65]  T. Uchida,et al.  [Minimally invasive therapy for bladder and prostate cancer]. , 2001, Gan to kagaku ryoho. Cancer & chemotherapy.

[66]  F A Jolesz,et al.  MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study. , 2001, Radiology.

[67]  W L Nyborg,et al.  Biological effects of ultrasound: development of safety guidelines. Part II: general review. , 2001, Ultrasound in medicine & biology.

[68]  J. Bernheim,et al.  Ultrasound imaging-guided noninvasive ultrasound thrombolysis: preclinical results. , 2000, Circulation.

[69]  W L Nyborg,et al.  Biological effects of ultrasound: development of safety guidelines. Part I: personal histories. , 2000, Ultrasound in medicine & biology.

[70]  R. Tasker,et al.  Percutaneous Radiofrequency Facet Rhizotomy – Experience with 118 Procedures and Reappraisal of its Value , 2000, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[71]  P. Dayton,et al.  Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles. , 1999, Ultrasound in medicine & biology.

[72]  A. Brayman,et al.  Transient poration and cell surface receptor removal from human lymphocytes in vitro by 1 MHz ultrasound. , 1999, Ultrasound in medicine & biology.

[73]  M. Kaste,et al.  Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) , 1998, The Lancet.

[74]  F A Jolesz,et al.  Demonstration of potential noninvasive ultrasound brain therapy through an intact skull. , 1998, Ultrasound in medicine & biology.

[75]  J M Dubernard,et al.  [Preliminary results of the treatment of 44 patients with localized cancer of the prostate using transrectal focused ultrasound]. , 1998, Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie.

[76]  J V Braaten,et al.  Ultrasound Reversibly Disaggregates Fibrin Fibers , 1997, Thrombosis and Haemostasis.

[77]  Joseph P. Broderick,et al.  Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. , 1995 .

[78]  M. Kaste,et al.  Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) , 1995, JAMA.

[79]  M. Marberger,et al.  Effect of high-intensity focused ultrasound on human prostate cancer in vivo. , 1995, Cancer research.

[80]  Ferenc A. Jolesz,et al.  MR‐Guided Focused Ultrasound Surgery , 1992, Journal of computer assisted tomography.

[81]  F. Fry,et al.  Effects of high-intensity focused ultrasound in the treatment of experimental neuroblastoma. , 1992, Journal of pediatric surgery.

[82]  F A Jolesz,et al.  Acoustic pressure wave generation within an MR imaging system: Potential medical applications , 1991, Journal of magnetic resonance imaging : JMRI.

[83]  Patricia C. Rinaldi,et al.  Modification by focused ultrasound pulses of electrically evoked responses from an in vitro hippocampal preparation , 1991, Brain Research.

[84]  R. B. Roemer,et al.  Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial , 1991, Journal of Neuro-Oncology.

[85]  H. R. Silvers.  Lumbar Percutaneous Facet Rhizotomy , 1990, Spine.

[86]  K Hynynen,et al.  Demonstration of enhanced temperature elevation due to nonlinear propagation of focussed ultrasound in dog's thigh in vivo. , 1987, Ultrasound in medicine & biology.

[87]  Heimburger Rf.  Ultrasound augmentation of central nervous system tumor therapy. , 1985 .

[88]  W. Dewey,et al.  Thermal dose determination in cancer therapy. , 1984, International journal of radiation oncology, biology, physics.

[89]  L. Frizzell,et al.  Localized tissue destruction by high-intensity focused ultrasound. , 1973, Archives of surgery.

[90]  J. Pond,et al.  Trackless lesions in nervous tissues produced by high intensity focused ultrasound (high-frequency mechanical waves). , 1968, Journal of anatomy.

[91]  E. N. Harvey,et al.  BIOLOGICAL ASPECTS OF ULTRASONIC WAVES, A GENERAL SURVEY , 1930 .

[92]  B. Gostout,et al.  Pregnancy outcome after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for conservative treatment of uterine fibroids. , 2010, Fertility and sterility.

[93]  Kiyoshi Namba,et al.  The evolving non-surgical ablation of breast cancer: Mr Guided focused ultrasound (MRgFUS) , 2007, Breast cancer.

[94]  Stephen Meairs,et al.  Ultrasound, microbubbles and the blood-brain barrier. , 2007, Progress in biophysics and molecular biology.

[95]  Elizabeth A Stewart,et al.  Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. , 2006, Fertility and sterility.

[96]  Y. Nishimura,et al.  Increased heating efficiency of hyperthermia using an ultrasound contrast agent: a phantom study. , 1998, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[97]  L. Gavrilov,et al.  Application of focused ultrasound for the stimulation of neural structures. , 1996, Ultrasound in medicine & biology.

[98]  J M Dubernard,et al.  Treatment of prostate cancer with transrectal focused ultrasound: early clinical experience. , 1996, European urology.

[99]  D. Rosberger,et al.  Immunomodulation in choroidal melanoma: reversal of inverted CD4/CD8 ratios following treatment with ultrasonic hyperthermia. , 1994, Biotechnology therapeutics.

[100]  J. Chapelon,et al.  [Effects of high-intensity focused ultrasound on the human prostate]. , 1993, Journal d'urologie.

[101]  R Souchon,et al.  High-intensity focused ultrasound experimentation on human benign prostatic hypertrophy. , 1993, European urology.

[102]  K. Hynynen.  The threshold for thermally significant cavitation in dog's thigh muscle in vivo. , 1991, Ultrasound in medicine & biology.

[103]  Silverstein Hr.  Lumbar percutaneous facet rhizotomy. , 1990 .

[104]  R. Heimburger.  Ultrasound augmentation of central nervous system tumor therapy. , 1985, Indiana medicine : the journal of the Indiana State Medical Association.

[105]  L. Lyons,et al.  Biij Biomedical Imaging and Intervention Journal Uncomplicated Term Vaginal Delivery following Magnetic Resonance-guided Focused Ultrasound Surgery for Uterine Fibroids , 2022 .