Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase.

[1]  L. Pellegrini,et al.  Structures of human primase reveal design of nucleotide elongation site and mode of Pol α tethering , 2013, Proceedings of the National Academy of Sciences.

[2]  L. Blanco,et al.  Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ , 2012, Nucleic acids research.

[3]  C. Richardson,et al.  Zinc-binding Domain of the Bacteriophage T7 DNA Primase Modulates Binding to the DNA Template* , 2012, The Journal of Biological Chemistry.

[4]  J. Berger,et al.  Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases. , 2012, Structure.

[5]  Smita S. Patel,et al.  Dynamic coupling between the motors of DNA replication: hexameric helicase, DNA polymerase, and primase. , 2011, Current opinion in chemical biology.

[6]  D. Ramsden Polymerases in nonhomologous end joining: building a bridge over broken chromosomes. , 2011, Antioxidants & redox signaling.

[7]  T. Tahirov,et al.  Crystal structure of the C-terminal domain of human DNA primase large subunit , 2011, Cell cycle.

[8]  L. Blanco,et al.  Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. , 2011, Molecular cell.

[9]  W. Chazin,et al.  Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase , 2010, Proceedings of the National Academy of Sciences.

[10]  Hisao Masai,et al.  Eukaryotic chromosome DNA replication: where, when, and how? , 2010, Annual review of biochemistry.

[11]  S. MacNeill,et al.  The eukaryotic replicative DNA polymerases take shape. , 2010, Trends in biochemical sciences.

[12]  G. Stengel,et al.  Mechanism and evolution of DNA primases. , 2010, Biochimica et biophysica acta.

[13]  L. Pellegrini,et al.  Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase , 2010, PloS one.

[14]  M. O’Donnell,et al.  Whither the replisome: Emerging perspectives on the dynamic nature of the DNA replication machinery , 2009, Cell cycle.

[15]  Gulden Camci-Unal,et al.  Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis , 2008, Chemistry Central journal.

[16]  J. Berger,et al.  Identification of a DNA primase template tracking site redefines the geometry of primer synthesis , 2008, Nature Structural &Molecular Biology.

[17]  W. Chazin,et al.  An Iron-Sulfur Cluster in the C-terminal Domain of the p58 Subunit of Human DNA Primase* , 2007, Journal of Biological Chemistry.

[18]  T. Kunkel,et al.  Role of the catalytic metal during polymerization by DNA polymerase lambda. , 2007, DNA repair.

[19]  E. G. Frank,et al.  Increased Catalytic Activity and Altered Fidelity of Human DNA Polymerase ι in the Presence of Manganese* , 2007, Journal of Biological Chemistry.

[20]  Airlie J. McCoy,et al.  Solving structures of protein complexes by molecular replacement with Phaser , 2006, Acta crystallographica. Section D, Biological crystallography.

[21]  J. Berger,et al.  Regulation of bacterial priming and daughter strand synthesis through helicase-primase interactions , 2006, Nucleic acids research.

[22]  S. Bell,et al.  Structure of the heterodimeric core primase , 2005, Nature Structural &Molecular Biology.

[23]  Detlef D. Leipe,et al.  Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members , 2005, Nucleic acids research.

[24]  O. Nureki,et al.  Crystal structure of the Pyrococcus horikoshii DNA primase‐UTP complex: implications for the mechanism of primer synthesis , 2003, Genes to cells : devoted to molecular & cellular mechanisms.

[25]  G. Maga,et al.  Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. , 2003, Biochemistry.

[26]  A. Doherty,et al.  A family of DNA repair ligases in bacteria? , 2001, FEBS letters.

[27]  E. Koonin,et al.  Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system. , 2001, Genome research.

[28]  J. Berger,et al.  Structure of the RNA polymerase domain of E. coli primase. , 2000, Science.

[29]  R. Kuchta,et al.  Human DNA primase: anion inhibition, manganese stimulation, and their effects on in vitro start-site selection. , 1999, Biochemistry.

[30]  R. Kuchta,et al.  Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: primase and the family X polymerases share significant sequence homology. , 1999, Biochemistry.

[31]  Xuewen Pan,et al.  Heterologous URA3MX cassettes for gene replacement in Saccharomyces cerevisiae , 1999, Yeast.

[32]  L. Csernoch,et al.  Measurements of intracellular Mg2+ concentration in mouse skeletal muscle fibers with the fluorescent indicator mag-indo-1. , 1998, Biophysical journal.

[33]  S. Doublié,et al.  Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution , 1998, Nature.

[34]  W. Copeland Expression, Purification, and Characterization of the Two Human Primase Subunits and Truncated Complexes fromEscherichia coli , 1997 .

[35]  R. Müller,et al.  Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. , 1995, Gene.

[36]  W. Copeland,et al.  Active Site Mapping of the Catalytic Mouse Primase Subunit by Alanine Scanning Mutagenesis (*) , 1995, The Journal of Biological Chemistry.

[37]  W. Copeland,et al.  Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication. , 1993, The Journal of biological chemistry.

[38]  R. Sheaff,et al.  Mechanism of calf thymus DNA primase: slow initiation, rapid polymerization, and intelligent termination. , 1993, Biochemistry.

[39]  R. Sikorski,et al.  A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. , 1989, Genetics.

[40]  J R Johnston,et al.  Genealogy of principal strains of the yeast genetic stock center. , 1986, Genetics.

[41]  D. Eichler,et al.  Effect of Mn2+ on the in vitro activity of human deoxyribonucleic acid polymerase beta. , 1977, Biochemistry.

[42]  Seahee Kim,et al.  Insertion and deletion mutagenesis by overlap extension PCR. , 2010, Methods in molecular biology.

[43]  Anindya Dutta,et al.  DNA replication in eukaryotic cells. , 2002, Annual review of biochemistry.

[44]  S. Benkovic,et al.  Replisome-mediated DNA replication. , 2001, Annual review of biochemistry.

[45]  J. Berger,et al.  Primus inter pares (First among equals) , 2001, Nature Structural Biology.

[46]  C. Richardson,et al.  DNA primases. , 2001, Annual review of biochemistry.

[47]  Robert Huber,et al.  Crystal structure of a DNA-dependent RNA polymerase (DNA primase) , 2001, Nature Structural Biology.

[48]  Z. Otwinowski,et al.  Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[49]  W. Copeland Expression, purification, and characterization of the two human primase subunits and truncated complexes from Escherichia coli. , 1997, Protein Expression and Purification.

[50]  F. Wedler,et al.  Manganese in metabolism and enzyme function , 1986 .

[51]  R. Rothstein One-step gene disruption in yeast. , 1983, Methods in enzymology.