HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker.

Families with multiple cases of leprosy were tested for HLA (histocompatibility leukocyte antigen)-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR2. Thirty-one non-HLA genetic markers were also examined for indications of non-HLA-linked genetic factors that might control susceptibility to tuberculoid leprosy. A significant (P = 0.002) preferential inheritance of HLA-DR2 by siblings affected with tuberculoid leprosy, but not by healthy siblings nor by siblings affected with lepromatous leprosy, was observed. In addition, combined family data showed a significant (P less than 0.0025) excess of identical HLA haplotypes inherited from healthy parents by siblings affected with tuberculoid leprosy. Segregation on non-HLA polymorphisms did not deviate significantly from what would have occured randomly. These data are compatible with a recessive inheritance of HLA-linked susceptibility to tuberculoid leprosy. The preferential segregation of DR2 observed in children with tuberculoid leprosy (P less than 0.001 for the combined data from India) indicates that the HLA-linked susceptibility gene is either DR2 or in linkage disequilibrium with it.

[1]  H. Mcdevitt,et al.  Histocompatibility-linked immune response genes. , 1972, Science.

[2]  H. Waldmann,et al.  The major histocompatibility system and the immune response. , 1978, British medical bulletin.

[3]  Ridley Ds,et al.  Classification of leprosy according to immunity. A five-group system. , 1966 .

[4]  R. Germain,et al.  The Immune Response Genes of the Major Histocompatibility Complex , 1978, Immunological reviews.

[5]  J. Rood,et al.  HLA-UNKED GENETIC CONTROL OF HOST RESPONSE TO MYCOBACTERIUM LEPRÆ , 1976, The Lancet.

[6]  S. Kobayashi,et al.  HLA antigen and susceptibility to leprosy. , 1977, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.

[7]  R. Walford,et al.  Histocompatibility Antigens in Leprosy 1 , 1975, Vox sanguinis.

[8]  C. Gorodezky,et al.  Distribution of some of the HL‐A System Lymphocyte Antigens in Mexicans , 1973, Vox sanguinis.

[9]  J. Ploem,et al.  Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants , 1976, Nature.

[10]  H. Mcdevitt,et al.  HL-A, immune-response genes, and disease. , 1974, Lancet.

[11]  M. Sada,et al.  HLA and mycobacterial infection: increased frequency of B8 in Japanese leprosy. , 1978, Tissue Antigens.

[12]  N. Mehra,et al.  HLA-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR types. , 2008, Tissue antigens.

[13]  U. Youngchaiyud,et al.  The Incidence of HLA Antigens in Leprosy , 1977, Vox sanguinis.

[14]  A. Svejgaard,et al.  HL‐A and Disease Associations ‐ A Survey , 1975, Transplantation reviews.

[15]  F. Vogel,et al.  A twin study on leprosy , 1973 .

[16]  P. Terasaki,et al.  Histocompatibility antigens in patients with leprosy. , 1976, The Journal of infectious diseases.

[17]  E. Thorsby,et al.  HL-A antigens and susceptibility to diseases. II. Leprosy. , 2008, Tissue antigens.

[18]  G. Fraser,et al.  Gene frequencies in a Dutch population. , 1974, Human heredity.

[19]  P. Fine,et al.  HLA-linked genes and leprosy: a family study in Karigiri, South India. , 1979, The Journal of infectious diseases.

[20]  N. Mehra,et al.  Histocompatibility antigens (HL-A) in leprosy. , 2008, Tissue antigens.

[21]  A. Bootello,et al.  HL-A antigens in leprosy. , 2008, Tissue antigens.