Despite the heterogeneous characteristics of cancellous bone, most of the published studies report correlations between mechanical properties and morphometric parameters averaged on the whole specimen [Goulet 1994, Majumdar 1998]. Goulet and Majumdar found a significant improvement in description of mechanical properties variation using a combination of structural parameters and bone volume fraction (BV/TV). Recently the effect of the “off-axis angle” between the load direction and the main trabecular direction (MTD) was established [Ohman 2007]. Recent studies [Nazarian 2006, Perilli 2007] showed that bone-sample failure is mostly localized within the sub-region showing a minimum value of BV/TV (BV/TVmin). Aim of the present work is to propose a method of local analysis able to summarize morphometric, anisotropic and off-axis parameters in a coherent manner.