Contrast‐enhanced optical coherence tomography for melanoma detection: An in vitro study

Optical coherence tomography (OCT), with a high spatial resolution (<10 microns), intermediate penetration depth (~1.5 mm), and volumetric imaging capability is a great candidate to be used as a diagnostic-assistant modality in dermatology. At this time, the accuracy of OCT for melanoma detection is lower than anticipated. In this letter, we studied for the first time, the use of a novel contrast agent consist of ultra-small nanoparticles conjugated to a melanoma biomarker to improve the accuracy of OCT for differentiation of melanoma cells from non-melanoma cells, in vitro. We call this approach SMall nanoparticle Aggregation-enhanced Radiomics of Tumor (SMART)-OCT imaging. This initial proof of concept study is the first step towards the broad utilization of this method for high-accuracy all types of tumor detection applications. This article is protected by copyright. All rights reserved.

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