Functional characterization of monoclonal auto‐antiidiotype antibodies isolated from the early B cell repertoire of BALB/c mice

A large number of hybridomas were constructed by fusion of B cells from perinatal liver and spleen. Many of these showed multispecificity, high interconnectivity and anti‐idiotype (Id) activity. Several of these were subjected to a detailed analysis to evaluate their influence on the developing immune system.

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