Mammographic Breast Density Evaluation in Korean Women Using Fully Automated Volumetric Assessment

The purpose was to present mean breast density of Korean women according to age using fully automated volumetric assessment. This study included 5,967 screening normal or benign mammograms (mean age, 46.2 ± 9.7; range, 30–89 years), from cancer-screening program. We evaluated mean fibroglandular tissue volume, breast tissue volume, volumetric breast density (VBD), and the results were 53.7 ± 30.8 cm3, 383.8 ± 205.2 cm3, and 15.8% ± 7.3%. The frequency of dense breasts and mean VBD by age group were 94.3% and 19.1% ± 6.7% for the 30s (n = 1,484), 91.4% and 17.2% ± 6.8% for the 40s (n = 2,706), 72.2% and 12.4% ± 6.2% for the 50s (n = 1,138), 44.0% and 8.6% ± 4.3% for the 60s (n = 89), 39.1% and 8.0% ± 3.8% for the 70s (n = 138), and 39.1% and 8.0% ± 3.5% for the 80s (n = 12). The frequency of dense breasts was higher in younger women (n = 4,313, 92.3%) than older women (n = 1,654, 59.8%). Mean VBD decreased with aging or menopause, and was about 16% for 46-year-old-Korean women, much higher than in other countries. The proportion of dense breasts sharply decreases in Korean women between 40 and 69 years of age.

[1]  Nico Karssemeijer,et al.  Volumetric Breast Density Estimation from Full-Field Digital Mammograms: A Validation Study , 2014, IEEE Transactions on Medical Imaging.

[2]  Jacques Ferlay,et al.  GLOBOCAN 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012 , 2013 .

[3]  Heang-Ping Chan,et al.  Mammographic density measured with quantitative computer-aided method: comparison with radiologists' estimates and BI-RADS categories. , 2006, Radiology.

[4]  Nico Karssemeijer,et al.  Robust breast composition measurement - Volpara™ , 2010 .

[5]  Jennifer A Harvey,et al.  Quantitative assessment of mammographic breast density: relationship with breast cancer risk. , 2004, Radiology.

[6]  K. Jung,et al.  Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010 , 2013, Cancer research and treatment : official journal of Korean Cancer Association.

[7]  Nico Karssemeijer,et al.  Robust Breast Composition Measurement - VolparaTM , 2010, Digital Mammography / IWDM.

[8]  J. Youk,et al.  Radiologist assessment of breast density by BI-RADS categories versus fully automated volumetric assessment. , 2013, AJR. American journal of roentgenology.

[9]  B. Han,et al.  Automated volumetric breast density estimation: a comparison with visual assessment. , 2013, Clinical radiology.

[10]  N. Taira,et al.  Association between mammographic breast density and lifestyle in Japanese women. , 2013, Acta medica Okayama.

[11]  Karla Kerlikowske,et al.  Prospective breast cancer risk prediction model for women undergoing screening mammography. , 2006, Journal of the National Cancer Institute.

[12]  Mammographic breast density patterns among a group of women in sub Saharan Africa. , 2013, African health sciences.

[13]  Hee Jung Moon,et al.  Mammographic Density Estimation with Automated Volumetric Breast Density Measurement , 2014, Korean journal of radiology.

[14]  E. Halpern,et al.  Mammographic breast density and race. , 2007, AJR. American journal of roentgenology.

[15]  L. Liberman,et al.  Breast imaging reporting and data system (BI-RADS). , 2002, Radiologic clinics of North America.

[16]  Eun-Kyung Kim,et al.  Supplementary Screening Sonography in Mammographically Dense Breast: Pros and Cons , 2010, Korean journal of radiology.

[17]  Ralph Highnam,et al.  Age and Ethnic Differences in Volumetric Breast Density in New Zealand Women: A Cross-Sectional Study , 2013, PloS one.

[18]  Karla Kerlikowske,et al.  Using Clinical Factors and Mammographic Breast Density to Estimate Breast Cancer Risk: Development and Validation of a New Predictive Model , 2008, Annals of Internal Medicine.

[19]  Jessica W T Leung,et al.  The California breast density information group: a collaborative response to the issues of breast density, breast cancer risk, and breast density notification legislation. , 2013, Radiology.

[20]  K. Oh,et al.  Analysis and Comparison of Breast Density according to Age on Mammogram between Korean and Western Women , 2000 .

[21]  E. Somers.  International Agency for Research on Cancer. , 1985, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[22]  Bill Bynum,et al.  Lancet , 2015, The Lancet.

[23]  T. M. Kolb,et al.  Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations. , 2002, Radiology.

[24]  S. Ciatto,et al.  Breast density as a determinant of interval cancer at mammographic screening , 2004, British Journal of Cancer.

[25]  Jiyon Lee,et al.  The relationship of mammographic density and age: implications for breast cancer screening. , 2012, AJR. American journal of roentgenology.

[26]  R. Birdwell,et al.  Breast density: clinical implications and assessment methods. , 2015, Radiographics : a review publication of the Radiological Society of North America, Inc.

[27]  Hyunsoon Cho,et al.  Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015 , 2018, Cancer research and treatment : official journal of Korean Cancer Association.

[28]  V. McCormack,et al.  Ethnic variations in mammographic density: a British multiethnic longitudinal study. , 2008, American journal of epidemiology.

[29]  P. Stomper,et al.  Analysis of parenchymal density on mammograms in 1353 women 25-79 years old. , 1996, AJR. American journal of roentgenology.

[30]  K. Choi,et al.  Reproductive and Hormonal Factors Associated with Fatty or Dense Breast Patterns among Korean Women , 2011, Cancer research and treatment : official journal of Korean Cancer Association.

[31]  Karla Kerlikowske,et al.  Agreement of Mammographic Measures of Volumetric Breast Density to MRI , 2013, PloS one.