Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in obesity

[1]  J. Manson,et al.  Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics , 2022, Immunity & ageing : I & A.

[2]  Emily F. Calderbank,et al.  Clonal dynamics of haematopoiesis across the human lifespan , 2021, Nature.

[3]  P. Campbell,et al.  The longitudinal dynamics and natural history of clonal haematopoiesis , 2021, Nature.

[4]  J. Borén,et al.  Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society , 2021, European heart journal.

[5]  L. Shlush,et al.  The vicious and virtuous circles of clonal hematopoiesis , 2021, Nature Medicine.

[6]  J. Manson,et al.  Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential: Results From the Women's Health Initiative , 2021, Journal of the American Heart Association.

[7]  Johannes G. Reiter,et al.  Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis , 2021, Cell.

[8]  Q. Morris,et al.  Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood , 2020, Nature Communications.

[9]  A. Zeiher,et al.  Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations. , 2020, European heart journal.

[10]  A. Zeiher,et al.  Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure , 2020, Circulation research.

[11]  Maya N. Polackal,et al.  TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity , 2020, Cell reports.

[12]  Markku Peltonen,et al.  Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study. , 2020, The New England journal of medicine.

[13]  B. Nordestgaard,et al.  Low HDL (High-Density Lipoprotein) Cholesterol and High White Blood Cell Counts: A Mendelian Randomization Study. , 2020, Arteriosclerosis, thrombosis, and vascular biology.

[14]  A. Murphy,et al.  Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism , 2020, Trends in Endocrinology & Metabolism.

[15]  E. Pietras,et al.  Tet2-mediated clonal hematopoiesis in non-conditioned mice accelerates age-associated cardiac dysfunction. , 2020, JCI insight.

[16]  S. Gabriel,et al.  Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis , 2019, Circulation.

[17]  B. Ebert,et al.  Clonal hematopoiesis in human aging and disease , 2019, Science.

[18]  M. Sabatine,et al.  2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. , 2019, European heart journal.

[19]  P. Libby,et al.  Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease , 2019, Nature Reviews Cardiology.

[20]  Fei Lan,et al.  Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer , 2018, Nature.

[21]  K. Walsh,et al.  Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease , 2018, Circulation research.

[22]  Christopher A. Miller,et al.  Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential , 2018, Nature Communications.

[23]  Christian Gilissen,et al.  Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life. , 2017, American journal of human genetics.

[24]  S. Gabriel,et al.  Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease , 2017, The New England journal of medicine.

[25]  Matthew A. Cooper,et al.  Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice , 2017, Science.

[26]  T. Druley,et al.  Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults , 2016, Nature Communications.

[27]  A. Tall,et al.  Disordered haematopoiesis and athero-thrombosis. , 2016, European heart journal.

[28]  B. Ebert,et al.  Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. , 2015, Blood.

[29]  M. McCarthy,et al.  Age-related clonal hematopoiesis associated with adverse outcomes. , 2014, The New England journal of medicine.

[30]  C. Bouchard,et al.  Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. , 2014, JAMA.

[31]  A. Tall,et al.  Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. , 2014, Cell metabolism.

[32]  F. Welty.  How Do Elevated Triglycerides and Low HDL-Cholesterol Affect Inflammation and Atherothrombosis? , 2013, Current Cardiology Reports.

[33]  E. Riboli,et al.  Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications , 2013, Nature Genetics.

[34]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[35]  A. Benetos,et al.  “Is obesity linked to aging?” Adipose tissue and the role of telomeres , 2012, Ageing Research Reviews.

[36]  R. Collins,et al.  Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies , 2009, The Lancet.

[37]  Allan Vaag,et al.  Interleukin-1-receptor antagonist in type 2 diabetes mellitus. , 2007, The New England journal of medicine.

[38]  A. Aviv,et al.  Obesity, cigarette smoking, and telomere length in women , 2005, The Lancet.

[39]  Claude Bouchard,et al.  Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. , 2004, The New England journal of medicine.

[40]  D. Allison,et al.  Years of life lost due to obesity. , 2003, JAMA.

[41]  F. Escobar,et al.  White blood cell count and insulin resistance in patients with coronary artery disease. , 2001, Annales d'endocrinologie.