Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways

[1]  M. Mareel,et al.  Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase‐ and thromboxane A2 receptor‐dependent signaling pathways , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  P. Dent,et al.  Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway* , 2001, The Journal of Biological Chemistry.

[3]  R. Evans,et al.  An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[4]  T. Willson,et al.  The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[5]  M. Mareel,et al.  Induction of scattering and cellular invasion by trefoil peptides in src‐ and RhoA‐transformed kidney and colonic epithelial cells , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  J. Rafter,et al.  Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells. , 2001, Gastroenterology.

[7]  M. Mareel,et al.  Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3‐kinase‐, Rho‐, and Rac‐dependent signaling pathways , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  L. Slice,et al.  Differential regulation of COX-2 transcription by Ras- and Rho-family of GTPases. , 2000, Biochemical and biophysical research communications.

[9]  F. Schliess,et al.  Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. , 2000, The Biochemical journal.

[10]  J. Winnie,et al.  Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme. , 2000, European journal of cancer.

[11]  G. Rogler,et al.  Characterization of bile salt-induced apoptosis in colon cancer cell lines. , 2000, Cancer research.

[12]  K. Prydz,et al.  Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2. , 2000, The Biochemical journal.

[13]  G. Gores,et al.  The Bile Acid Taurochenodeoxycholate Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade* , 2000, The Journal of Biological Chemistry.

[14]  J. Lord,et al.  Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis. , 2000, Biochemical and biophysical research communications.

[15]  Jesse D. Martinez,et al.  Bile Acid-induced Activation of Activator Protein-1 Requires Both Extracellular Signal-regulated Kinase and Protein Kinase C Signaling* , 2000, The Journal of Biological Chemistry.

[16]  John G. Collard,et al.  Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition , 2000, The Journal of cell biology.

[17]  B. Rigas,et al.  The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a colon carcinogen. , 2000, Carcinogenesis.

[18]  J. Abita,et al.  Functional interactions between bile acids, all-trans retinoic acid, and 1,25-dihydroxy-vitamin D3 on monocytic differentiation and myeloblastin gene down-regulation in HL60 and THP-1 human leukemia cells. , 2000, Cancer research.

[19]  John G. Collard,et al.  Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory Behavior , 1999 .

[20]  F. André,et al.  Integrins and E‐cadherin cooperate with IGF‐I to induce migration of epithelial colonic cells , 1999, International journal of cancer.

[21]  John G. Collard,et al.  Rho-like GTPases , 1999 .

[22]  K. Nabeshima,et al.  TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-α and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment , 1999, Clinical & Experimental Metastasis.

[23]  Stefano Panzeri,et al.  Correlated firing and the information represented by neurons in short epochs , 1999, Neurocomputing.

[24]  M. Makishima,et al.  Identification of a nuclear receptor for bile acids. , 1999, Science.

[25]  Jasmine Chen,et al.  Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. , 1999, Molecular cell.

[26]  T. Kamano,et al.  Ratio of primary and secondary bile acids in feces , 1999, Diseases of the colon and rectum.

[27]  Timothy J. Yeatman,et al.  Activating SRC mutation in a subset of advanced human colon cancers , 1999, Nature Genetics.

[28]  Frank Speleman,et al.  The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells , 1999, Oncogene.

[29]  V. Berezin,et al.  Fra-1 Induces Morphological Transformation and Increases In Vitro Invasiveness and Motility of Epithelioid Adenocarcinoma Cells , 1998, Molecular and Cellular Biology.

[30]  Frits Michiels,et al.  Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase , 1998, The Journal of cell biology.

[31]  M. Taketo,et al.  Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas. , 1998, Cancer research.

[32]  J. C. Pratt,et al.  The Small GTP-Binding Protein Rho Potentiates AP-1 Transcription in T Cells , 1998, Molecular and Cellular Biology.

[33]  W. Nelson,et al.  Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity , 1998, The Journal of cell biology.

[34]  A. G. de Herreros,et al.  Protein Kinase C-α Activity Inversely Modulates Invasion and Growth of Intestinal Cells* , 1998, The Journal of Biological Chemistry.

[35]  M. Mareel,et al.  Inhibition by Platelet-activating Factor of Src- and Hepatocyte Growth Factor-dependent Invasiveness of Intestinal and Kidney Epithelial Cells , 1998, The Journal of Biological Chemistry.

[36]  D. Alberts,et al.  Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps. , 1998, Cancer research.

[37]  Fan Zhang,et al.  Dihydroxy Bile Acids Activate the Transcription of Cyclooxygenase-2* , 1998, The Journal of Biological Chemistry.

[38]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[39]  Johann Hofmann,et al.  The potential for isoenzyme‐selective modulation of protein kinase C , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  R. DuBois,et al.  Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[41]  G. Berx,et al.  Cadherin/catenin complex: A target for antiinvasive therapy? , 1996, Journal of cellular biochemistry.

[42]  H. Handa,et al.  Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. , 1996, Carcinogenesis.

[43]  F. Nagengast,et al.  Role of bile acids in colorectal carcinogenesis. , 1995, European journal of cancer.

[44]  Tadataka Yamada,et al.  Textbook of Gastroenterology , 1995 .

[45]  J. Lord,et al.  Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids , 1995, International journal of cancer.

[46]  V. Quaranta,et al.  A Monoclonal Antibody Inhibits Adhesion to Fibronectin and Vitronectin of a Colon Carcinoma Cell Line and Recognizes the Integrins αvβ3, αvβ5, and αvβ6 , 1994 .

[47]  M. Mareel,et al.  Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro. , 1993, British Journal of Cancer.

[48]  N. W. Ross,et al.  Toxicity of bile acids to colon cancer cell lines. , 1993, Cancer letters.

[49]  M. Castagna,et al.  Bile acids, non‐phorbol‐ester‐type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29 , 1992, International journal of cancer.

[50]  G A Colditz,et al.  Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. , 1990, The New England journal of medicine.

[51]  L. Liotta,et al.  Characteristics of invasive and noninvasive human colorectal adenocarcinoma cells. , 1990, Journal of the National Cancer Institute.

[52]  C. Paraskeva,et al.  Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence. , 1990, Cancer research.

[53]  J. Summerton,et al.  Bile acid receptors in colorectal cancer , 1983, The British journal of surgery.

[54]  E. Wynder,et al.  Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats. , 1977, Cancer research.

[55]  E. Wynder,et al.  Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats. , 1974, Journal of the National Cancer Institute.

[56]  Jesse D. Martinez,et al.  Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis. , 2001, Carcinogenesis.

[57]  M. Mareel,et al.  Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion. , 1997, British Journal of Cancer.

[58]  R. Owen.  Faecal Steroids and Colorectal Carcinogenesis. , 1997, Scandinavian journal of gastroenterology.

[59]  G. Paumgartner,et al.  Increased serum deoxycholic acid levels in men with colorectal adenomas. , 1993, Gastroenterology.