OK-432: an effective sclerosing agent for the treatment of lymphangiomas of head and neck.

OBJECTIVE The basic objective of this study was to find out the efficacy of OK-432 for the conservative treatment of lymphangiomas of head and neck regions at the Department of ENT-Head & Neck Surgery of Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal. METHODS It was a hospital based prospective, cross-sectional, case series, conducted among the patients suffering from different lymphangiomas of head and neck regions and treated with intra-lesional injection of OK-432, from March, 2005 to September 2006. Altogether eleven patients were enrolled in this modality of treatment out of which one patient was excluded from the study, which was treated surgically due to very ugly scar at the site of lesion resulting from previous surgery for the same. The data were analyzed by using simple mathematical tools like percentage and frequency. RESULTS Out of ten patients treated with intralesional injection of OK-432, absolute response, i.e. total resolution of swelling was found in nine patients (90%) after the first dose. Remaining one patient also responded well on the treatment but some residual swelling was in situ for which second dose was given. After the second dose it was also totally resolved. In this way we achieved 100% response after the second dose of OK-432. CONCLUSION The results of this study so far indicate that OK-432 is an effective and safe tool for the treatment of lymphangioma of head and neck region. As the procedure can be done in an out patient department, without hospitalization and has got minimal side effects, it can be proposed as the first line treatment of lymphangiomas of head and neck.

[1]  H. Mau,et al.  Huge intra- and extrathoracic lymphangioma in a baby successfully treated by sclerotherapy with OK-432. , 2006, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

[2]  A. Tregnaghi,et al.  Further experience with OK-432 for lymphangiomas , 2005, Pediatric Surgery International.

[3]  M. Höllwarth,et al.  OK-432 therapy of lymphangiomas in children , 1996, European Journal of Pediatrics.

[4]  L. Barbier,et al.  OK432 (picibanil) efficacy in an adult with cystic cervical lymphangioma. A case report. , 2005, Medicina oral, patologia oral y cirugia bucal.

[5]  J. Perkins,et al.  Management of lymphatic malformations , 2004, Current opinion in otolaryngology & head and neck surgery.

[6]  M. Mahadevan,et al.  OK‐432 and lymphatic malformations in children: the Starship Children's Hospital experience , 2004, ANZ journal of surgery.

[7]  D. Gozal,et al.  OK‐432 Therapy for Cervical Lymphangioma , 2004, The Laryngoscope.

[8]  M. Davies,et al.  Guidelines for the successful treatment of lymphangioma with OK-432. , 2003, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

[9]  E. Laasonen,et al.  Treatment of Lymphangiomas with OK-432 (Picibanil) , 2003, CardioVascular and Interventional Radiology.

[10]  Yutaka Sato,et al.  Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial. , 2002, Archives of otolaryngology--head & neck surgery.

[11]  R. Kuylenstierna,et al.  OK-432 therapy for lymphatic malformation in 32 patients (28 children). , 2002, International journal of pediatric otorhinolaryngology.

[12]  J. Laranne,et al.  OK-432 (Picibanil) therapy for lymphangiomas in children , 2002, European Archives of Oto-Rhino-Laryngology.

[13]  B. Charabi Cystic Hygroma of the Head and Neck - A Long-term Follow-up of 44 Cases , 2000, Acta oto-laryngologica. Supplementum.

[14]  E. Deguchi,et al.  OK-432 therapy for lymphangioma in children: why and how does it work? , 1996, Journal of pediatric surgery.

[15]  E. Deguchi,et al.  OK-432 therapy in 64 patients with lymphangioma. , 1994, Journal of pediatric surgery.

[16]  Shaw Hj,et al.  Reconstruction following surgical removal of extensive malignant tumors of the mouth and pharynx , 1976 .

[17]  Ellis Be Congenital anomalies of the head and neck. , 1948 .