The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.

[1]  David M. Wilson,et al.  The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. , 2006, Bioorganic & medicinal chemistry letters.

[2]  G. Feuerstein,et al.  Significant Neuroprotection against Ischemic Brain Injury by Inhibition of the MEK1 Protein Kinase in Mice: Exploration of Potential Mechanism Associated with Apoptosis , 2003, Journal of Pharmacology and Experimental Therapeutics.

[3]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[4]  M. Moskowitz,et al.  Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[5]  M. Cobb,et al.  Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. , 2001, Endocrine reviews.

[6]  P. Cohen,et al.  Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .

[7]  P. Selzer,et al.  Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. , 2000, Journal of medicinal chemistry.

[8]  M. Salgaller American Association for Cancer Research , 2000, Expert opinion on investigational drugs.

[9]  A. Reith,et al.  Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat. , 2000, Brain research. Molecular brain research.

[10]  Denis M. Bayada,et al.  Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs , 1999, Pharmaceutical Research.

[11]  T. Bach,et al.  The Preparation of 2,3,5‐Tri‐ and 2,3‐Disubstituted Furans by Regioselective Palladium(0)‐Catalyzed Coupling Reactions: Application to the Syntheses of Rosefuran and the F5 Furan Fatty Acid , 1999 .