The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.
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Robert P. Davis | David M. Wilson | A. Reith | F. King | Beverley Smith | T. Stean | A. Naylor | A. Takle | D. Dean | M. Bamford | P. C. Staton | A. Gaiba | S. Davies | J. G. Steadman | Alison M. Ray | C. Parr | E. Irving | D. K. Dean
[1] David M. Wilson,et al. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. , 2006, Bioorganic & medicinal chemistry letters.
[2] G. Feuerstein,et al. Significant Neuroprotection against Ischemic Brain Injury by Inhibition of the MEK1 Protein Kinase in Mice: Exploration of Potential Mechanism Associated with Apoptosis , 2003, Journal of Pharmacology and Experimental Therapeutics.
[3] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[4] M. Moskowitz,et al. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[5] M. Cobb,et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. , 2001, Endocrine reviews.
[6] P. Cohen,et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .
[7] P. Selzer,et al. Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. , 2000, Journal of medicinal chemistry.
[8] M. Salgaller. American Association for Cancer Research , 2000, Expert opinion on investigational drugs.
[9] A. Reith,et al. Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat. , 2000, Brain research. Molecular brain research.
[10] Denis M. Bayada,et al. Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs , 1999, Pharmaceutical Research.
[11] T. Bach,et al. The Preparation of 2,3,5‐Tri‐ and 2,3‐Disubstituted Furans by Regioselective Palladium(0)‐Catalyzed Coupling Reactions: Application to the Syntheses of Rosefuran and the F5 Furan Fatty Acid , 1999 .