论文信息 - Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile. - 字舞流文

Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile.

D. J. Rogier | A. Bahinski | P. Scherle | R. Devraj | M. Covington | Joseph Glenn | B. Metcalf | R. Newton | C. Xue | Z. Mo | Li-Juan Xing | R. Hughes | Philip A Morton | Hao Feng | Ganfeng Cao | Rajan Anand | Ke Zhang | Changsheng Zheng | M. Xia | John W. Davis | Fredric Baribaud | J. Hutzler