Ovarian granulosa cell tumor and acromegaly.

AMENORRHEA is one of the most consistent and usually one of the earliest symptoms of pituitary tumor in women. Menstrual function may return, however, even after a prolonged period of amenorrhea, following surgical removal of the tumor, its shrinkage by roentgen irradiation, or possibly in rare instances following the escape of the expanding tumor from the sella turcica with consequent decompression of the normal elements of the gland. In the following unique case resumption of uterine bleeding occurred in an acromegalic as the result of a coincidental lesion, namely, a granulosa cell tumor of the ovary. Case report.—The patient was a 42-year-old white, married, Russian-born housewife, who was first seen at the Columbia-Presbyterian Medical Center September 16, 1948, with the complaint of enlargement of the hands and feet and distortion of the face. These symptoms, first observed by the patient about six years before, had been preceded for about three years by excessive fatigue and frequent blurring of vi...