Wide dynamic range specific detection of therapeutic drugs by photonic crystal microcavity arrays

Six orders of magnitude wide dynamic range (0.1ng/ml to over 100μg/ml), label-free detection of gentamicin small molecules with silicon photonic crystal microcavity biosensors multiplexed by multimode interference power splitters was experimentally demonstrated. Detection specificity was confirmed.

[1]  Liang Tang,et al.  Label-free detection of cardiac troponin I with a photonic crystal biosensor. , 2014, Biosensors & bioelectronics.

[2]  Ray T. Chen,et al.  Cavity-Waveguide Coupling Engineered High Sensitivity Silicon Photonic Crystal Microcavity Biosensors With High Yield , 2014, IEEE Journal of Selected Topics in Quantum Electronics.

[3]  A Densmore,et al.  Photonic wire biosensor microarray chip and instrumentation with application to serotyping of Escherichia coli isolates. , 2013, Optics express.

[4]  Miss A.O. Penney.  (b) , 1974, The New Yale Book of Quotations.

[5]  Anthony Turner,et al.  Biosensors and Bioelectronics 16 , 2001 .

[6]  Feng Liang,et al.  Scalable photonic crystal chips for high sensitivity protein detection. , 2013, Optics express.

[7]  Ray T. Chen,et al.  Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors. , 2014, Applied physics letters.

[8]  Ray T. Chen,et al.  Slow light enhanced sensitivity of resonance modes in photonic crystal biosensors. , 2013, Applied physics letters.

[9]  Muzammil Iqbal,et al.  Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[10]  Deyu Li,et al.  Biomolecule kinetics measurements in flow cell integrated porous silicon waveguides , 2012, Biomedical optics express.

[11]  Alp Artar,et al.  Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes , 2010 .