This self-management (SM) trial evaluated tailored action plans for exacerbations of COPD and comorbid conditions in Australian and Dutch patients. Primary outcome analyses demonstrated a reduction in COPD exacerbation duration and respiratory-related hospitalisation rate. This abstract reports secondary study endpoints. COPD patients (≥ 40 years, GOLD II-IV) with ≥ 1 comorbidity (ischemic heart disease, chronic heart failure, diabetes mellitus, anxiety, depression) were randomised to a SM intervention including individualised exacerbation action plans for COPD and comorbidities (n=102) or usual care (n=99). Health status (Chronic Respiratory Disease (CRQ) and the Hospital Anxiety and Depression Scale (HADS)), self-efficacy (COPD Self-Efficacy Scale (CSES)), and fatigue were assessed at baseline, 6 and 12 months. Between-group differences were studied with repeated measurements analyses. Compared to usual care, SM showed a significantly reduced behavioural risk factors CSES domain (difference -0.26 (95% CI -0.52;-0.01), p=0.04) and a significantly worse emotional function CRQ domain (difference -0.41 (95% CI -0.70;-0.11), p SM including exacerbation action plans for COPD and comorbidities improved patients’ self-efficacy to prevent breathing difficulty. Lower emotional function scores in the SM group were not accompanied with HADS changes and may result from more symptom awareness due to training. Further tailoring of our individualised SM action plans and associated case-manager support may enhance self-efficacy and (mental) health status.